Jump to ContentJump to Main Navigation

You are looking at 1-19 of 19 items

  • Keywords: drug discovery x
Clear All Modify Search

View:

Ancestral Sequence Reconstruction

David A Liberles (ed.)

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.001.0001
Subject:
Biology, Evolutionary Biology / Genetics

Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological ... More


Measuring Competence? Exploring Firm Effects in Drug Discovery

Rebecca Henderson and Iain Cockburn

in The Nature and Dynamics of Organizational Capabilities

Published in print:
2001
Published Online:
November 2003
ISBN:
9780199248544
eISBN:
9780191596155
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/0199248540.003.0007
Subject:
Economics and Finance, Microeconomics

The chapter explores the role of ‘competence’ in pharmaceutical research. It provides support for the existence of sources of heterogeneity highlighted by the resource‐based view of the firm by ... More


From Molecules to Medicines: The Use of Genetic Resources in Pharmaceutical Research

Astrid J. Scholz

in Engineering Trouble: Biotechnology and Its Discontents

Published in print:
2003
Published Online:
March 2012
ISBN:
9780520237612
eISBN:
9780520937499
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520237612.003.0009
Subject:
History, History of Science, Technology, and Medicine

This chapter describes the drug discovery process in pharmaceutical research to show how deeply the new biotechnologies constitute the politics and economics of genetic resources. The analysis ... More


The Drug Discovery Crisis

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0001
Subject:
Public Health and Epidemiology, Public Health

This chapter examines the current problem associated with creating new drugs—that so few proteins are considered druggable. It first traces the history of how existing drugs were created. It then ... More


A New Science of Molecules

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0002
Subject:
Public Health and Epidemiology, Public Health

This chapter explains how small molecules came to be used as drugs and how they function mechanistically. It begins by focusing on the emergence of organic chemistry and the role played by Justus von ... More


Accelerating the Arrival of Next-Generation Drugs

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0013
Subject:
Public Health and Epidemiology, Public Health

This chapter focuses on the challenge of accelerating the development of next-generation drugs against undruggable proteins. There are more than 20,000 proteins encoded in the human genome, but only ... More


The Birth of the First Cancer Drugs

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0003
Subject:
Public Health and Epidemiology, Public Health

This chapter traces the origins of today’s cancer drugs. It begins with the discovery of sulfur mustard in 1886 by the German chemist Viktor Meyer, who synthesized in pure form ... More


A New Company Creating Drug Combinations

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0004
Subject:
Public Health and Epidemiology, Public Health

This chapter focuses on the birth of a biopharmaceutical company that sought to identify combinations of existing drugs that could be effective in diseases that drugs have never been used for. One ... More


The Undruggable RAS Protein

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0005
Subject:
Public Health and Epidemiology, Public Health

This chapter discusses the challenge of creating effective medicines based on information from disease-causing genes by focusing on the history of the RAS oncoprotein. The RAS oncoprotein is a ... More


Disease and Its Treatment

Lawrence E. Hunter

in The Processes of Life: An Introduction to Molecular Biology

Published in print:
2009
Published Online:
August 2013
ISBN:
9780262013055
eISBN:
9780262255288
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262013055.003.0009
Subject:
Biology, Biochemistry / Molecular Biology

This chapter explores the fundamentals of human disease and its treatment. It begins with a discussion on the general principles of pathology and therapeutics. It then examines healing in organisms, ... More


Peering Inside Proteins

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0007
Subject:
Public Health and Epidemiology, Public Health

This chapter examines why some proteins are more susceptible to modulation by small molecule drugs than other proteins. To this end, the chapter presents an atom-by-atom picture of proteins and where ... More


Taking Advantage of Emergence

Deborah Dougherty

in The Emergence of Novelty in Organizations

Published in print:
2015
Published Online:
April 2015
ISBN:
9780198728313
eISBN:
9780191795275
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198728313.003.0007
Subject:
Business and Management, Innovation

Innovators in complex innovation systems can more productively generate new products if they deliberately take advantage of emergence. Focusing on drug discovery, the chapter develops three abductive ... More


The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Brent Stockwell

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
book
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.001.0001
Subject:
Public Health and Epidemiology, Public Health

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. This book describes this dilemma and ... More


A Future Bright and Dark

Lynn C. Klotz and Edward J. Sylvester

in Breeding Bio Insecurity: How U.S. Biodefense Is Exporting Fear, Globalizing Risk, and Making Us All Less Secure

Published in print:
2009
Published Online:
February 2013
ISBN:
9780226444055
eISBN:
9780226444079
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226444079.003.0002
Subject:
Biology, Biotechnology

Discoveries in molecular biology are changing the understanding of human complexity and unraveling these newfound complexities requires emerging disciplines such as systems biology. Some strategies ... More


The Druggable Genome

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0006
Subject:
Public Health and Epidemiology, Public Health

This chapter discusses the importance of the druggable genome, the subset of the human genome that encodes proteins that can be affected by drugs, in the future of medicine. It begins with an ... More


A Vast Array of Drug Candidates

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0011
Subject:
Public Health and Epidemiology, Public Health

This chapter examines how the invention of solid-phase peptide synthesis and the birth of combinatorial chemistry have made it possible to screen and allow for the collection of massive amounts of ... More


Conclusion

Murphy Halliburton

in India and the Patent Wars: Pharmaceuticals in the New Intellectual Property Regime

Published in print:
2017
Published Online:
September 2018
ISBN:
9781501713460
eISBN:
9781501713972
Item type:
chapter
Publisher:
Cornell University Press
DOI:
10.7591/cornell/9781501713460.003.0007
Subject:
Anthropology, Asian Cultural Anthropology

The conclusion reiterates the problems with analyzing this new constellation of power and of predicting its outcomes. Certain effective provisions are highlighted such as Section 3d of India’s new ... More


The Project Subsystem in the Infrastructure for Complex Innovation Systems: Navigating in the Labyrinth

Deborah Dougherty

in Taking Advantage of Emergence: Productively Innovating in Complex Innovation Systems

Published in print:
2016
Published Online:
April 2016
ISBN:
9780198725299
eISBN:
9780191792649
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198725299.003.0003
Subject:
Business and Management, Innovation, Knowledge Management

Organizations began generating streams of new products only recently. Building products that actually solve customer problems required new social technologies for extensive interdisciplinary work to ... More


Science, the State, and the City: Britain's Struggle to Succeed in Biotechnology

Geoffrey Owen and Michael M. Hopkins

Published in print:
2016
Published Online:
May 2016
ISBN:
9780198728009
eISBN:
9780191794308
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198728009.001.0001
Subject:
Business and Management, Innovation, International Business

The book examines the evolution of a new industrial sector based on one of the most important technologies that has emerged in the last fifty years—biotechnology, the use of living organisms to ... More


View: