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From Conception to Commercial Success

Cynthia M. Ho

in Access to Medicine in the Global Economy: International Agreements on Patents and Related Rights

Published in print:
2011
Published Online:
May 2011
ISBN:
9780195390124
eISBN:
9780199894536
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195390124.003.0002
Subject:
Law, Intellectual Property, IT, and Media Law

This chapter provides an overview of how drugs are brought to market, focusing on themes important for understanding subsequent chapters. It explains how patented versus generic drugs are made, ... More


Macromolecular crystallography in drug design

Sherin S. Abdel-Meguid

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0017
Subject:
Biology, Biochemistry / Molecular Biology

This chapter discusses macromolecular crystallography in drug discovery. Currently, all large and most small pharmaceutical and biotechnology companies have invested in macromolecular ... More


Case Studies

Don Rose and Cam Patterson

in Research To Revenue: A Practical Guide to University Start-Ups

Published in print:
2016
Published Online:
May 2016
ISBN:
9781469625263
eISBN:
9781469625287
Item type:
chapter
Publisher:
University of North Carolina Press
DOI:
10.5149/northcarolina/9781469625263.003.0005
Subject:
Business and Management, Innovation

Three case studies are presented to demonstrate the key steps discussed in Chapter 3. The case studies are (fictitious) examples of university startups, covering the range of startups typically found ... More


Economic Impacts of the Personalized Medicine Tsunami

Dan Segal and David E. Williams

in Integrative Neuroscience and Personalized Medicine

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195393804
eISBN:
9780199863495
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393804.003.0014
Subject:
Neuroscience, Disorders of the Nervous System

We are in one of the most exciting periods in the evolution of health care. Never before have so many variables (that directly impact the basis of patient care) simultaneously been in transition. ... More


The Alchemy of Empire: Drugs and Development in the Americas

Suzanna Reiss

in We Sell Drugs: The Alchemy of US Empire

Published in print:
2014
Published Online:
September 2016
ISBN:
9780520280779
eISBN:
9780520959026
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520280779.003.0005
Subject:
History, American History: 20th Century

Raw drug materials imported by U.S. pharmaceutical companies became the foundation for a therapeutic revolution. Governments and corporations embraced drug research and development to lengthen life, ... More


Anti-Malarial Drug Development and Diffusion in an Era of Multidrug Resistance: How Can an Integrated Health Framework Contribute to Sustainable Development Goal 3?

Freek de Haan and Ellen H.M. Moors

in Science, Technology, and Innovation for Sustainable Development Goals: Insights from Agriculture, Health, Environment, and Energy

Published in print:
2020
Published Online:
August 2020
ISBN:
9780190949501
eISBN:
9780197528907
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190949501.003.0013
Subject:
Political Science, Political Theory

The ability to ensure healthy lives and well-being (SDG3, healthy lives) is dependent on accessible and affordable healthcare for everyone in need. However, people in low and middle-income countries ... More


Characterizing the Drug Development Pipeline for Precision Medicines

Amitabh Chandra, Craig Garthwaite, and Ariel Dora Stern

in Economic Dimensions of Personalized and Precision Medicine

Published in print:
2019
Published Online:
September 2019
ISBN:
9780226611068
eISBN:
9780226611235
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226611235.003.0006
Subject:
Economics and Finance, Microeconomics

Precision medicines—therapies that rely on the use of genetic, epigenetic, and protein biomarkers—create a better match between patients with specific disease subtypes and medications that are more ... More


Blockbuster Mab Drugs

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0009
Subject:
History, History of Science, Technology, and Medicine

This chapter explores the development of rituximab and infliximab, two of the best-selling monoclonal antibody (Mab) therapeutics today. The evolution of these drugs not only illustrates how a single ... More


The Challenge of Monoclonal Antibody Drugs

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0007
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the efforts to develop monoclonal antibody (Mab) therapeutics. The quick commercialization of Mab diagnostics prompted many to assume that Mab therapeutics would soon reach the ... More


A classification of peripheral analgesics based upon their mode of action

Sérgio H. Ferreira

in Migraine: A Spectrum of Ideas

Published in print:
1990
Published Online:
March 2012
ISBN:
9780192618108
eISBN:
9780191724305
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192618108.003.0006
Subject:
Neuroscience, Disorders of the Nervous System

This chapter aims to discuss current ideas about the mechanism of action of peripheral analgesics, and to provide a rational basis both for their therapeutic use and for the development of new drugs. ... More


Science, Law, and the Medical‐Industrial Complex in EU Pharmaceutical Regulation: The Deferiprone Controversy

John Abraham and Courtney Davis

in European Law and New Health Technologies

Published in print:
2013
Published Online:
May 2013
ISBN:
9780199659210
eISBN:
9780191748165
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199659210.003.0011
Subject:
Law, EU Law, Medical Law

This chapter is a case study of the controversy surrounding a thalassaemia drug, known as deferiprone. The approval of the drug for the EU market was appealed, to what was then the European Court of ... More


The Information Pharms Race and Competitive Dynamics of Precision Medicine: Insights from Game Theory

Ernst R. Berndt and Mark R. Trusheim

in Economic Dimensions of Personalized and Precision Medicine

Published in print:
2019
Published Online:
September 2019
ISBN:
9780226611068
eISBN:
9780226611235
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226611235.003.0005
Subject:
Economics and Finance, Microeconomics

Precision medicines inherently fragment treatment populations, generating small-population markets, creating high-priced “niche busters” rather than broadly prescribed “blockbusters." It is plausible ... More


AIDS Activists and People with AIDS: A Movement to Revolutionize Research and for Universal Access to Treatment

Mark Harrington

in Tactical Biopolitics: Art, Activism, and Technoscience

Published in print:
2008
Published Online:
August 2013
ISBN:
9780262042499
eISBN:
9780262271127
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262042499.003.0019
Subject:
Society and Culture, Media Studies

This chapter compares the changing and contested notions of expertise wielded by AIDS activists and people with AIDS with those of the scientific experts and government officials. From this cultural ... More


Beyond Technonationalism: Biomedical Innovation and Entrepreneurship in Asia

Kathryn C. Ibata-Arens

Published in print:
2019
Published Online:
September 2019
ISBN:
9781503605473
eISBN:
9781503608757
Item type:
book
Publisher:
Stanford University Press
DOI:
10.11126/stanford/9781503605473.001.0001
Subject:
Business and Management, Political Economy

What explains the rapid and sustained economic rise of Asian countries in high-technology industries, including biomedicals? The biomedical industry, comprised mainly of biopharmaceuticals and ... More


Antibody Engineering: A Renaissance for Mab Therapeutics

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0008
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the emergence of engineered monoclonal antibodies (Mabs) in the 1990s. The failure of Centoxin to gain FDA approval prompted many in the biotechnology and pharmaceutical ... More


From Rodent Behavioral Models to Human Disorders

Trevor W. Robbins

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0012
Subject:
Neuroscience, Research and Theory

To what extent is it feasible to generalize behavior in rodents to complex cognitive functions in humans via rodent models of neurodegenerative diseases or neuropsychiatric disorders? This chapter ... More


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