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The Replication Problem

Frederic Lawrence Holmes

in Meselson, Stahl, and the Replication of DNA: A History of "The Most Beautiful Experiment in Biology"

Published in print:
2001
Published Online:
October 2013
ISBN:
9780300085402
eISBN:
9780300129663
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300085402.003.0002
Subject:
History, History of Science, Technology, and Medicine

This chapter begins with one of the most famous sentences in the literature of science—the statement near the end of the brief article in Nature made by Francis Crick and James Watson that goes thus: ... More


Conclusion: The Double Helix and the Dialectic

Thomas Albert Howard

in God and the Atlantic: America, Europe, and the Religious Divide

Published in print:
2011
Published Online:
May 2011
ISBN:
9780199565511
eISBN:
9780191725654
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199565511.003.0006
Subject:
Religion, History of Christianity

This concluding chapter summarizes the arguments of the book and places them in a broader historical perspective: the disparate trajectories of modernity (vis-à-vis religion) set in motion by the ... More


The Subunits of Semiconservative Replication

Frederic Lawrence Holmes

in Meselson, Stahl, and the Replication of DNA: A History of "The Most Beautiful Experiment in Biology"

Published in print:
2001
Published Online:
October 2013
ISBN:
9780300085402
eISBN:
9780300129663
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300085402.003.0013
Subject:
History, History of Science, Technology, and Medicine

This chapter describes the immediate impact the publication of the Meselson-Stahl experiment in PNAS had on the circle of biologists already engaged with the replication of DNA, and how it extended ... More


Meselson, Stahl, and the Replication of DNA: A History of "The Most Beautiful Experiment in Biology"

Frederic Lawrence Holmes

Published in print:
2001
Published Online:
October 2013
ISBN:
9780300085402
eISBN:
9780300129663
Item type:
book
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300085402.001.0001
Subject:
History, History of Science, Technology, and Medicine

In 1957, two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently ... More


Time's Arrow

Howard Marchitello

in The Machine in the Text: Science and Literature in the Age of Shakespeare and Galileo

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199608058
eISBN:
9780191729492
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199608058.003.0007
Subject:
Literature, 16th-century and Renaissance Literature, Shakespeare Studies

This chapter returns to a series of challenges posed famously in C. P. Snow's The Two Cultures and the Scientific Revolution, particularly Snow's assessment of the science-literature agon and his ... More


The double helix

Sydney Brenner

in A Century of Nature: Twenty-One Discoveries that Changed Science and the World

Published in print:
2003
Published Online:
May 2013
ISBN:
9780226284132
eISBN:
9780226284163
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226284163.003.0006
Subject:
History, History of Science, Technology, and Medicine

Although most of modern biology stems from this brief paper, there is also a long prehistory of thought in the subject that is now known as genetics. Morgan's research was largely responsible for ... More


Crossing Fields: Chemical Bonds to Biological Mutants

Frederic Lawrence Holmes

in Meselson, Stahl, and the Replication of DNA: A History of "The Most Beautiful Experiment in Biology"

Published in print:
2001
Published Online:
October 2013
ISBN:
9780300085402
eISBN:
9780300129663
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300085402.003.0005
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses Meselson's view that, in order to approach the design of the replication experiment of which he dreamed, he must first understand in detail the structure and chemistry of the ... More


Introduction

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0001
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Nerve impulses traversing the brain were likened by Sherrington to points of light in an enchanted loom. The electrochemical nature of the nerve impulse was largely elucidated by Hodgkin and Huxley ... More


Perl for Exploring DNA

Mark D. LeBlanc and Betsey Dexter Dyer

Published in print:
2007
Published Online:
April 2010
ISBN:
9780195305890
eISBN:
9780199773862
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195305890.001.0001
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

The book presents a hands-on introductory guide to DNA sequence analysis. This can be depicted as a linear map of As, Cs, Gs, and Ts; however, such a map only hints at the varied contours and ... More


The Double Helix: Truth, Proclamation, and Judgement

Graham Ward

in How the Light Gets In: Ethical Life I

Published in print:
2016
Published Online:
March 2016
ISBN:
9780199297658
eISBN:
9780191791987
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199297658.003.0007
Subject:
Religion, Religion and Society, Theology

This chapter introduces the way an engaged systematics understands a number of key terms in any discussion of the Christian faith. It develops both the accounts of communicative relations and ... More


Introduction to DNA

David Bensimon, Vincent Croquette, Jean-François Allemand, Xavier Michalet, and Terence Strick

in Single-Molecule Studies of Nucleic Acids and Their Proteins

Published in print:
2018
Published Online:
February 2019
ISBN:
9780198530923
eISBN:
9780191864711
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198530923.003.0001
Subject:
Physics, Soft Matter / Biological Physics

This chapter provides a quick introduction to the structural properties of nucleic acids (DNA and RNA). It describes the famed double-helical structure of DNA, the more complex 3D structures adopted ... More


Empirical Background and the Bases for the Investigation

Albert Rothenberg

in Flight from Wonder: An Investigation of Scientific Creativity

Published in print:
2014
Published Online:
November 2014
ISBN:
9780199988792
eISBN:
9780190214159
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199988792.003.0004
Subject:
Psychology, Cognitive Psychology

The empirical investigation into scientific creativity begins with several primary-source accounts of theoretical breakthroughs from great scientists of the past. Featured are Albert Einstein’s ... More


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