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The Role of Dopamine in the Motivational Vulnerability to Addiction

George F. Koob and Michel Le Moal

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0026
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter discusses the role of dopamine in addiction. Research over the past 50 years has revealed that the mesocorticolimbic dopamine system has an essential role in the acute reinforcing ... More


Functional Neuroanatomy of Dopamine in the Striatum

Charles R. Gerfen

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0002
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter begins with a discussion of the mesostriatal dopamine system. It then covers striatal patch-matrix compartments, input—output organization of the striatal patch and matrix compartments, ... More


Dopamine Modulation of Forebrain Pathways and the Pathophysiology of Psychiatric Disorders

Anthony A. Grace

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0041
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Dopamine (DA) has received substantial attention due to its involvement in a wide array of neurological and psychiatric disorders, ranging from Parkinson's disease to affective disorders and ... More


Role of Dopamine Systems in Cognitive Aging

Lars Bäckman and Lars Farde

in Cognitive Neuroscience of Aging: Linking cognitive and cerebral aging

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195156744
eISBN:
9780199864171
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195156744.003.0003
Subject:
Neuroscience, Behavioral Neuroscience, Development

This chapter reviews literature on the influence of age-related changes in the nigrostriatal dopamine (DA) system on age-related cognitive changes. The chapter is organized as follows: first, it ... More


From Behavior to Cognition: Functions of Mesostriatal, Mesolimbic, and Mesocortical Dopamine Systems

Trevor W. Robbins

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0014
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter reviews the role of dopamine (DA) in mesostriatal, mesolimbic, and mesocortical systems in experimental animals and humans. It appears that each of these systems is “tuned” according to ... More


A brief history of the anhedonia hypothesis

Roy A. Wise

in Appetite: Neural and Behavioural Bases

Published in print:
1994
Published Online:
March 2012
ISBN:
9780198547877
eISBN:
9780191724275
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198547877.003.0010
Subject:
Neuroscience, Behavioral Neuroscience

This chapter discusses the history of the so-called anhedonia hypothesis. The term anhedonia was first used in 1978 in connection with the assertion that pimozide blocks the reward quality of food. ... More


Medical Models of Addiction

Harold Kincaid and Jacqueline A. Sullivan

in What Is Addiction?

Published in print:
2010
Published Online:
August 2013
ISBN:
9780262513111
eISBN:
9780262288248
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262513111.003.0014
Subject:
Psychology, Cognitive Psychology

This chapter offers an explicit description of the assumptions of medical models, the different forms they may take, and the challenges they face in providing explanations with solid evidence of ... More


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