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Phase I Research and the Meaning of ‘Prospect of Direct Benefit’

Lainie Friedman Ross

in Children in Medical Research: Access versus Protection

Published in print:
2006
Published Online:
May 2006
ISBN:
9780199273287
eISBN:
9780191603655
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/0199273286.003.0007
Subject:
Philosophy, Moral Philosophy

This chapter examines the issue of whether phase I pediatric oncology trials offer the prospect of direct benefit. Phase I research is carried out to determine toxicity; the possibility of direct ... More


Children in clinical trials in Ireland: addressing the gaps in the legal framework

Katherine Wade

in Ethical and Legal Debates In Irish Healthcare: Confronting complexities

Published in print:
2016
Published Online:
May 2016
ISBN:
9780719099465
eISBN:
9781526104410
Item type:
chapter
Publisher:
Manchester University Press
DOI:
10.7228/manchester/9780719099465.003.0012
Subject:
Sociology, Culture

This chapter focuses on two key areas which require further clarity and elaboration in the context of research with children, namely, the requirements for research which does not offer the child the ... More


The Case for Valuing Non-Health and Indirect Benefits

Govind Persad and Jessica du Toit

in Global Health Priority-Setting: Beyond Cost-Effectiveness

Published in print:
2019
Published Online:
December 2019
ISBN:
9780190912765
eISBN:
9780190912796
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190912765.003.0012
Subject:
Philosophy, Philosophy of Science

Health policy is only one part of social policy. Although spending administered by the health sector constitutes a sizeable fraction of total state spending in most countries, other sectors such as ... More


Benefit in phase 1 oncology trials: Therapeutic misconception or reasonable treatment option?

Steven Joffe

in The Ethical Challenges of Human Research: Selected Essays

Published in print:
2012
Published Online:
May 2015
ISBN:
9780199896202
eISBN:
9780190267681
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:osobl/9780199896202.003.0010
Subject:
Philosophy, Moral Philosophy

This chapter examines the key issues of fact and value regarding the direct medical benefit of phase 1 oncology trials. It considers the numerous uncertainties, related both to causal inference and ... More


The evolution of polyandry

Rhonda R. Snook

in The Evolution of Insect Mating Systems

Published in print:
2014
Published Online:
October 2014
ISBN:
9780199678020
eISBN:
9780191788987
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199678020.003.0009
Subject:
Biology, Evolutionary Biology / Genetics, Animal Biology

Polyandry is widespread, but its origin and maintenance remains enigmatic. Direct benefits arising from polyandry are easy to understand, but the recent emphasis on sexual conflict over mating ... More


Self Interest

Alexander Gillespie

in International Environmental Law, Policy, and Ethics

Published in print:
2014
Published Online:
October 2014
ISBN:
9780198713456
eISBN:
9780191781896
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198713456.003.0003
Subject:
Law, Environmental and Energy Law, Public International Law

This chapter looks at the self-interest argument in the field of environmental protection and environmental policy and law in the international setting. The axiom of self interest, commonly ... More


The Programme

S.K. Das

in Making the Poor Free?: India's Unique Identification Number

Published in print:
2015
Published Online:
October 2015
ISBN:
9780199453290
eISBN:
9780199085378
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199453290.003.0004
Subject:
Political Science, Democratization

Chapter 4 is a study of the brochures, documents, blueprints, and background papers of the Aadhaar programme. According to this literature, the inability to prove identity has prevented India’s poor ... More


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