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SNPs, HapMap, and common disease

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0009
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

The extent of single nucleotide polymorphism is reviewed, together with insights gained into the nature of allelic architecture in terms of haplotypes, linkage disequilibrium and recombination. The ... More


Invalids and entrepreneurs

Mark Harrison

in Medicine in an age of Commerce and Empire: Britain and its Tropical Colonies 1660-1830

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199577736
eISBN:
9780191595196
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199577736.003.0010
Subject:
History, British and Irish Early Modern History

Chapter 9 explores the medical marketplace of early nineteenth‐century Britain, with particular reference to tropical invalids and others deemed to have similar complaints. The chapter focuses on the ... More


The voyager returns

Mark Harrison

in Medicine in an age of Commerce and Empire: Britain and its Tropical Colonies 1660-1830

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199577736
eISBN:
9780191595196
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199577736.003.0011
Subject:
History, British and Irish Early Modern History

This chapter examines some of the themes arising from earlier chapters through the career of James Johnson, one of the most influential practitioners of his day. After his retirement from the Royal ... More


Albion's coast is sick

Mark Harrison

in Medicine in an age of Commerce and Empire: Britain and its Tropical Colonies 1660-1830

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199577736
eISBN:
9780191595196
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199577736.003.0012
Subject:
History, British and Irish Early Modern History

Chapter 11 examines the career of the naval physician Thomas Trotter, who claimed that two‐thirds of the population were suffering the ill‐effects of luxury and nervous over‐stimulation. He believed ... More


Axonal degeneration and disorders of the axonal cytoskeleton

JOHN W. GRIFFIN, EDWIN B. GEORGE, SUNG-TSANG HSIEH, and JONATHAN D. GLASS

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0020
Subject:
Neuroscience, Disorders of the Nervous System

This chapter discusses cytoskeletal changes in axonal degeneration. It begins with a review of the organization of the normal axonal cytoskeleton, followed by a summary of the current understanding ... More


Down's Syndrome

DAVID WRIGHT

in Mental Disability in Victorian England: The Earlswood Asylum 1847-1901

Published in print:
2001
Published Online:
January 2010
ISBN:
9780199246397
eISBN:
9780191715235
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199246397.003.010
Subject:
History, British and Irish Modern History

Within traditional medical history, John Langdon Down is seen as a physician who was ‘in advance of his time’ in the treatment and classification of persons with mental disabilities. He was ... More


Modern Urban Lifestyles, Degeneration, and the Male Body

Ina Zweiniger‐Bargielowska

in Managing the Body: Beauty, Health, and Fitness in Britain 1880-1939

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199280520
eISBN:
9780191594878
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199280520.003.0002
Subject:
History, British and Irish Modern History

This chapter charts the emergence of life reform, vegetarianism, physical culture, and reducing culture, which have to be understood against the background of rapid urbanization, the rise of modern ... More


NONIDEAL PLASMA. BASIC CONCEPTS

V. E. Fortov, I. T. Iakubov, and A. G. Khrapak

in Physics of Strongly Coupled Plasma

Published in print:
2006
Published Online:
September 2007
ISBN:
9780199299805
eISBN:
9780191714948
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299805.003.0001
Subject:
Physics, Nuclear and Plasma Physics

This introductory chapter discusses different types of interparticle interactions (Coulomb, electron-atom, and ion-atom) and the criteria of nonideality. The classification of states is given and the ... More


Nervous Degeneration

Janet Oppenheim

in “Shattered Nerves”: Doctors, Patients, and Depression in Victorian England

Published in print:
1991
Published Online:
October 2011
ISBN:
9780195057812
eISBN:
9780199854394
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195057812.003.0009
Subject:
History, British and Irish Modern History

In 1905, the idea of nervous degeneration was inseparable from the more open discussion of moral degradation and physical debility. For a country beleaguered by worldwide competitors, nerves were ... More


The neuropsychological presentation of Alzheimer’s disease and other neurodegenerative disorders

Julie Snowden

in The Handbook of Clinical Neuropsychology

Published in print:
2010
Published Online:
September 2010
ISBN:
9780199234110
eISBN:
9780191594250
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199234110.003.028
Subject:
Psychology, Neuropsychology, Clinical Psychology

Alzheimer's disease and other neurodegenerative diseases that lead to progressive cognitive impairment are conventionally classified as ‘the dementias’. Dementia is traditionally defined as a ... More


Creating character: Theories of nature and nurture in Victorian sensation fiction

Helena Ifill

Published in print:
2018
Published Online:
September 2018
ISBN:
9781784995133
eISBN:
9781526136275
Item type:
book
Publisher:
Manchester University Press
DOI:
10.7228/manchester/9781784995133.001.0001
Subject:
Literature, Criticism/Theory

This book explores the range of ways in which the two leading sensation authors of the 1860s, Mary Elizabeth Braddon and Wilkie Collins, engaged with nineteenth-century ideas about how the ... More


Before Taking Food (Cath. 3)

Gerard O'Daly

in Days Linked by Song: Prudentius' Cathemerinon

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199263950
eISBN:
9780191741364
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199263950.003.0004
Subject:
Classical Studies, Literary Studies: Classical, Early, and Medieval, Poetry and Poets: Classical, Early, and Medieval

This chapter discusses the poem's presentation of appropriate Christian diet, moderate, avoiding the meat of quadrupeds, with meals preceded by prayer. Praise of food as the divine creator's gift is ... More


Disorders of the Self in Dementia

WILLIAM W. SEELEY and BRUCE L. MILLER

in The Lost Self: Pathologies of the Brain and Identity

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195173413
eISBN:
9780199865758
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195173413.003.0010
Subject:
Neuroscience, Molecular and Cellular Systems

The self is experienced as a unified whole, yet self-representation by the brain requires an interconnected hierarchy of parts that can be selectively dismantled by neurological disease. This idea is ... More


Arithmetic Compactifications of PEL-Type Shimura Varieties

Kai-Wen Lan

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691156545
eISBN:
9781400846016
Item type:
book
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691156545.001.0001
Subject:
Mathematics, Geometry / Topology

By studying the degeneration of abelian varieties with PEL structures, this book explains the compactifications of smooth integral models of all PEL-type Shimura varieties, providing the logical ... More


New Women and Neurasthenia: Nervous Degeneration and the 1890s

Jane Wood

in Passion and Pathology in Victorian Fiction

Published in print:
2001
Published Online:
October 2011
ISBN:
9780198187608
eISBN:
9780191674723
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198187608.003.0005
Subject:
Literature, 19th-century and Victorian Literature

This chapter discusses nervous degeneration and its literary representation in the 1890s. Much of the fiction of the 1890s self-consciously engages with the physical and medical sciences to configure ... More


Diversity as Degeneration

Justin E. H. Smith

in Nature, Human Nature, and Human Difference: Race in Early Modern Philosophy

Published in print:
2015
Published Online:
October 2017
ISBN:
9780691153643
eISBN:
9781400866311
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691153643.003.0006
Subject:
Philosophy, History of Philosophy

This chapter focuses on those early modern accounts of human phenotypic diversity that do not resort to claims of essential difference, but instead appeal to some form or other of degeneration to ... More


Monstrous Inversions: Decadence and Degeneration in Galdόs's Ángel Guerra

CATHERINE JAGOE

in Culture and Gender in Nineteenth-Century Spain

Published in print:
1996
Published Online:
September 2011
ISBN:
9780198158868
eISBN:
9780191673399
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198158868.003.0009
Subject:
Literature, European Literature, 19th-century and Victorian Literature

The notion of inevitable decline or degeneration produced an aesthetic movement that revolved around a group of ‘decadent’ or Symbolist writers and painters of the late 19th century whose subjects ... More


Remaking the Male Body: Masculinity and the uses of Physical Culture in Interwar and Vichy France

Joan Tumblety

Published in print:
2012
Published Online:
January 2013
ISBN:
9780199695577
eISBN:
9780191745072
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199695577.001.0001
Subject:
History, European Modern History, Cultural History

This book is about interwar physical culture as a set of popular practices and as a field of ideas. It takes as its central subject the imagined failure of French manhood that was mapped out in this ... More


Writing disenchantment: British First World War prose, 1914-30

Andrew Frayn

Published in print:
2014
Published Online:
January 2015
ISBN:
9780719089220
eISBN:
9781781707333
Item type:
book
Publisher:
Manchester University Press
DOI:
10.7228/manchester/9780719089220.001.0001
Subject:
Literature, European Literature

This book argues that disenchantment is not only a response to wartime experience, but a condition of modernity with a language that finds extreme expression in First World War literature. The ... More


Introduction: ‘Mens sana in corpore sano’: the fragile bodies of men

Joan Tumblety

in Remaking the Male Body: Masculinity and the uses of Physical Culture in Interwar and Vichy France

Published in print:
2012
Published Online:
January 2013
ISBN:
9780199695577
eISBN:
9780191745072
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199695577.003.0001
Subject:
History, European Modern History, Cultural History

The introduction explains the rationale and structure of the book. It introduces some of the key physical culturists of the era, stressing the number of them who were physicians whose work served to ... More


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