Wai-Kee Li, Gong-Du Zhou, and Thomas Mak
- Published in print:
- 2008
- Published Online:
- May 2008
- ISBN:
- 9780199216949
- eISBN:
- 9780191711992
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199216949.001.0001
- Subject:
- Physics, Crystallography
This text is an updated English version of a class-tested textbook originally published in Chinese in 2006. Its contents are based on the lecture notes of several courses taught by the authors at The ...
More
This text is an updated English version of a class-tested textbook originally published in Chinese in 2006. Its contents are based on the lecture notes of several courses taught by the authors at The Chinese University of Hong Kong and Peking University. These courses include Chemical Bonding, Structure and Properties of Matter, Advanced Inorganic Chemistry, Quantum Chemistry, Group Theory, and Chemical Crystallography. This book consists of three parts. Part I reviews the basic theories of chemical bonding, with chapters on elementary quantum theory, atomic structure, bonding in molecules, bonding in solids, and computational chemistry. Part II introduces point groups and space groups, and their applications to the study of discrete molecules and crystals. A large number of worked examples are provided in order to illustrate the usefulness and elegance of the symmetry concept. Part III constitutes about half of the book and it gives a succinct description of the structural chemistry of the elements in the Periodic Table. The main-group elements are covered in seven chapters and three other chapters deal with the rare-earth elements, transition-metal clusters and supramolecular systems. The selected systems, many of them from recent literature, are used to elucidate various aspects of structure and bonding presented in Parts I and II, and to expound the current research trends in structural inorganic chemistryLess
This text is an updated English version of a class-tested textbook originally published in Chinese in 2006. Its contents are based on the lecture notes of several courses taught by the authors at The Chinese University of Hong Kong and Peking University. These courses include Chemical Bonding, Structure and Properties of Matter, Advanced Inorganic Chemistry, Quantum Chemistry, Group Theory, and Chemical Crystallography. This book consists of three parts. Part I reviews the basic theories of chemical bonding, with chapters on elementary quantum theory, atomic structure, bonding in molecules, bonding in solids, and computational chemistry. Part II introduces point groups and space groups, and their applications to the study of discrete molecules and crystals. A large number of worked examples are provided in order to illustrate the usefulness and elegance of the symmetry concept. Part III constitutes about half of the book and it gives a succinct description of the structural chemistry of the elements in the Periodic Table. The main-group elements are covered in seven chapters and three other chapters deal with the rare-earth elements, transition-metal clusters and supramolecular systems. The selected systems, many of them from recent literature, are used to elucidate various aspects of structure and bonding presented in Parts I and II, and to expound the current research trends in structural inorganic chemistry
Maribel Navarro and Gonzalo Visbal
- Published in print:
- 2015
- Published Online:
- May 2016
- ISBN:
- 9780262029193
- eISBN:
- 9780262327619
- Item type:
- chapter
- Publisher:
- The MIT Press
- DOI:
- 10.7551/mitpress/9780262029193.003.0010
- Subject:
- Public Health and Epidemiology, Public Health
This review discusses the potential of metal-based compounds to act as safe and affordable drugs in the treatment of important tropical parasitic illnesses such as Chagas disease, leishmaniasis, and ...
More
This review discusses the potential of metal-based compounds to act as safe and affordable drugs in the treatment of important tropical parasitic illnesses such as Chagas disease, leishmaniasis, and malaria. Currently, half the world’s population is estimated to be at risk of contracting these vector-borne diseases, and almost one million people die annually from these diseases. No effective vaccine exists to treat these infectious diseases and available treatments are far from ideal. Coordination metal complexes offer potential in the development of new antiparasitic drugs. Indeed, coordination compounds in medicine are a growing and exciting research field, having been used successfully in cancer therapy. As an antiparasitic agent, ferroquine has entered phase II clinical trials against malaria and is an excellent example to encourage the development of antiparasitic metal-based drugs. Insights into the mechanism of actions of metal-based antiparasitic drugs are discussed.Less
This review discusses the potential of metal-based compounds to act as safe and affordable drugs in the treatment of important tropical parasitic illnesses such as Chagas disease, leishmaniasis, and malaria. Currently, half the world’s population is estimated to be at risk of contracting these vector-borne diseases, and almost one million people die annually from these diseases. No effective vaccine exists to treat these infectious diseases and available treatments are far from ideal. Coordination metal complexes offer potential in the development of new antiparasitic drugs. Indeed, coordination compounds in medicine are a growing and exciting research field, having been used successfully in cancer therapy. As an antiparasitic agent, ferroquine has entered phase II clinical trials against malaria and is an excellent example to encourage the development of antiparasitic metal-based drugs. Insights into the mechanism of actions of metal-based antiparasitic drugs are discussed.
Dieter Rehder, Robert E. Black, Julia Bornhorst, Rodney R. Dietert, Victor J. DiRita, Maribel Navarro, Robert D. Perry, Lothar Rink, Eric P. Skaar, Miguel C. P. Soares, Dennis J. Thiele, Fudi Wang, Günter Weiss, and Inga Wessels
- Published in print:
- 2015
- Published Online:
- May 2016
- ISBN:
- 9780262029193
- eISBN:
- 9780262327619
- Item type:
- chapter
- Publisher:
- The MIT Press
- DOI:
- 10.7551/mitpress/9780262029193.003.0013
- Subject:
- Public Health and Epidemiology, Public Health
This overview covers the role of the metal ions in infectious diseases, focusing on iron, copper, zinc, and, to a lesser extent, manganese and the metalloid selenium. Recommended dietary allowances ...
More
This overview covers the role of the metal ions in infectious diseases, focusing on iron, copper, zinc, and, to a lesser extent, manganese and the metalloid selenium. Recommended dietary allowances are addressed, as are metal-based drugs for the treatment of tropical diseases. The human organism binds essential metals such as iron, manganese, copper, and zinc to specific compounds (including proteins) in order to withhold these metals from invading pathogens (“nutritional immunity”); in this way, metal binding provides resistance to infection. Selenium status can also affect the host–pathogen interaction, but pathogens have mechanisms to counteract this protective potency. Due to the epidemic proportions of tropical diseases and lack of effective treatment, drugs are being developed that are based on coordination compounds of metals, including copper, iron, ruthenium, and gold. These metals are coordinated to aromatic ligand systems which allow drug stabilization, during the drug’s transport to its target, and eventually intercalation into DNA. For malaria, the increasing resistance of the malaria parasite against the classical drug chloroquine may be overcome by employing ferrocenyl derivatives of chloroquine.Less
This overview covers the role of the metal ions in infectious diseases, focusing on iron, copper, zinc, and, to a lesser extent, manganese and the metalloid selenium. Recommended dietary allowances are addressed, as are metal-based drugs for the treatment of tropical diseases. The human organism binds essential metals such as iron, manganese, copper, and zinc to specific compounds (including proteins) in order to withhold these metals from invading pathogens (“nutritional immunity”); in this way, metal binding provides resistance to infection. Selenium status can also affect the host–pathogen interaction, but pathogens have mechanisms to counteract this protective potency. Due to the epidemic proportions of tropical diseases and lack of effective treatment, drugs are being developed that are based on coordination compounds of metals, including copper, iron, ruthenium, and gold. These metals are coordinated to aromatic ligand systems which allow drug stabilization, during the drug’s transport to its target, and eventually intercalation into DNA. For malaria, the increasing resistance of the malaria parasite against the classical drug chloroquine may be overcome by employing ferrocenyl derivatives of chloroquine.
Enric Canadell, Marie-Liesse Doublet, and Christophe Iung
- Published in print:
- 2012
- Published Online:
- December 2013
- ISBN:
- 9780199534937
- eISBN:
- 9780191774935
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199534937.003.0002
- Subject:
- Physics, Condensed Matter Physics / Materials
This chapter reviews some useful notions that are needed to understand the electronic structure of molecules. It first discusses the basic aspects of molecular orbital theory and how symmetry may be ...
More
This chapter reviews some useful notions that are needed to understand the electronic structure of molecules. It first discusses the basic aspects of molecular orbital theory and how symmetry may be used to simplify the problem of defining the molecular orbitals by using group theory. The usefulness of these basic group theory notions are illustrated by considering the example of cyclobutadiene. Finally, the chapter looks at some general aspects of the electronic structure of transition metal coordination complexes.Less
This chapter reviews some useful notions that are needed to understand the electronic structure of molecules. It first discusses the basic aspects of molecular orbital theory and how symmetry may be used to simplify the problem of defining the molecular orbitals by using group theory. The usefulness of these basic group theory notions are illustrated by considering the example of cyclobutadiene. Finally, the chapter looks at some general aspects of the electronic structure of transition metal coordination complexes.
