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Detection of Copy Number Variations from Array Comparative Genomic Hybridization Data Using Linear-chain Conditional Random Field Models

Xiaolin Yin and Jing Li

in Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Published in print:
2014
Published Online:
December 2014
ISBN:
9780198709022
eISBN:
9780191779619
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198709022.003.0016
Subject:
Mathematics, Probability / Statistics, Biostatistics

Copy number variation (CNV) accounts for roughly 12% of the human genome. Beside their inherent role in cancer development, CNVs have been reported to underlie susceptibility to complex diseases. ... More


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