Thorsten Bartsch (ed.)
- Published in print:
- 2012
- Published Online:
- September 2012
- ISBN:
- 9780199592388
- eISBN:
- 9780199949922
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199592388.001.0001
- Subject:
- Neuroscience, Disorders of the Nervous System, Behavioral Neuroscience
The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body ...
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The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical, and neurocomputational literature that presents basic mechanisms, theoretical models, and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. This book explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural, and psychiatric symptoms and surpasses the ability to encode, store, and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia.Less
The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical, and neurocomputational literature that presents basic mechanisms, theoretical models, and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. This book explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural, and psychiatric symptoms and surpasses the ability to encode, store, and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia.
Frank E. Speizer and Ira B. Tager
- Published in print:
- 2007
- Published Online:
- September 2009
- ISBN:
- 9780198569541
- eISBN:
- 9780191724077
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198569541.003.0008
- Subject:
- Public Health and Epidemiology, Public Health, Epidemiology
This chapter traces the development of the epidemiology of chronic respiratory disease. The modern era of the study of the epidemiology of chronic obstructive pulmonary disease (COPD) did not blossom ...
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This chapter traces the development of the epidemiology of chronic respiratory disease. The modern era of the study of the epidemiology of chronic obstructive pulmonary disease (COPD) did not blossom until the middle of the 20th century. Before that time clinicians generally believed that much of the symptomatology associated with the disease represented a ‘normal’ state. In the last fifteen years, much of the epidemiological research has been directed to identifying the characteristics of these subgroups at risk before clinical disease is apparent.Less
This chapter traces the development of the epidemiology of chronic respiratory disease. The modern era of the study of the epidemiology of chronic obstructive pulmonary disease (COPD) did not blossom until the middle of the 20th century. Before that time clinicians generally believed that much of the symptomatology associated with the disease represented a ‘normal’ state. In the last fifteen years, much of the epidemiological research has been directed to identifying the characteristics of these subgroups at risk before clinical disease is apparent.
Can Cui
Katherine J. Strandburg and Brett M. Frischmann (eds)
- Published in print:
- 2014
- Published Online:
- November 2014
- ISBN:
- 9780199972036
- eISBN:
- 9780199361908
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199972036.003.0006
- Subject:
- Law, Intellectual Property, IT, and Media Law, Environmental and Energy Law
Information sharing, collaboration, and community building among researchers, doctors, and patients are critical to rare disease research. It is very difficult to do clinical research on rare ...
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Information sharing, collaboration, and community building among researchers, doctors, and patients are critical to rare disease research. It is very difficult to do clinical research on rare diseases; rareness means small numbers of patients, who usually are dispersed among geographically scattered medical centers. This chapter reports on a case study of the Rare Disease Clinical Research Network (RDCRN)’s Urea Cycle Disorders Consortium (UCDC) that employed the knowledge commons framework described in Chapter 1 of this volume. This case study is a step toward understanding whether and in what ways the RDCRN contributes to progress in combating rare diseases. Government funding for research is limited, and it is important to try to understand how various ways of structuring that funding influence the outcomes. Observations from close study of the UCDC generate hypotheses about the RDCRN approach that can be tested in comparative studies of other consortia.Less
Information sharing, collaboration, and community building among researchers, doctors, and patients are critical to rare disease research. It is very difficult to do clinical research on rare diseases; rareness means small numbers of patients, who usually are dispersed among geographically scattered medical centers. This chapter reports on a case study of the Rare Disease Clinical Research Network (RDCRN)’s Urea Cycle Disorders Consortium (UCDC) that employed the knowledge commons framework described in Chapter 1 of this volume. This case study is a step toward understanding whether and in what ways the RDCRN contributes to progress in combating rare diseases. Government funding for research is limited, and it is important to try to understand how various ways of structuring that funding influence the outcomes. Observations from close study of the UCDC generate hypotheses about the RDCRN approach that can be tested in comparative studies of other consortia.
