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Neuronal cell death

Julie Agapite and Hermann Steller

in Molecular and Cellular Approaches to Neural Development

Published in print:
1998
Published Online:
May 2009
ISBN:
9780195111668
eISBN:
9780199865833
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195111668.003.0007
Subject:
Neuroscience, Molecular and Cellular Systems, Development

This chapter focuses on recent progress in identifying genes that are directly involved in the control and execution of apoptosis. Topics covered include properties of the apoptotic program, control ... More


Models of Cellular Regulation

Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Published in print:
2008
Published Online:
September 2008
ISBN:
9780198570912
eISBN:
9780191718717
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198570912.001.0001
Subject:
Physics, Soft Matter / Biological Physics

The human genome of three billion letters has been sequenced. So have the genomes of thousands of other organisms. With unprecedented resolution, modern technologies are allowing us to peek into the ... More


Mechanisms controlling the development of cortical connections at the target

David J. Price and David J. Willshaw

in Mechanisms of Cortical Development

Published in print:
2000
Published Online:
January 2010
ISBN:
9780192624277
eISBN:
9780191723735
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192624277.003.0006
Subject:
Neuroscience, Development

The preceding chapters have described how the embryonic anatomy of the early forebrain is established under the control of regulatory genes and extracellular signalling molecules. This chapter ... More


Neurotrophic factors and their receptors: Roles in neuronal development and function

Louis F. Reichardt and Fariñas Isabel

in Molecular and Cellular Approaches to Neural Development

Published in print:
1998
Published Online:
May 2009
ISBN:
9780195111668
eISBN:
9780199865833
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195111668.003.0006
Subject:
Neuroscience, Molecular and Cellular Systems, Development

Neurotrophic factors are important regulators of the development and maintenance of vertebrate nervous system. During the development of the nervous system, neuronal populations undergo a process of ... More


The Origin of Cancer

Jeffrey Ecsedy and David Hunter

in Textbook of Cancer Epidemiology

Published in print:
2008
Published Online:
September 2009
ISBN:
9780195311174
eISBN:
9780199865093
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195311174.003.0003
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

One of the major goals in cancer research is to elucidate the molecular and cellular events driving the progression of cells from a normal to a cancerous state. This transformation relies on the ... More


Molecular Responses to Asbestos: Induction of Cell Proliferation and Apoptosis Through Modulation of Redox-Dependent Cell Signaling Pathways

Nicholas H. Heintz and Brooke T. Mossman

in Asbestos and Its Diseases

Published in print:
2008
Published Online:
September 2009
ISBN:
9780195178692
eISBN:
9780199864591
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195178692.003.0005
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses how asbestos interacts with cell-signaling pathways to modulate cell functions, including induction of proliferation and cell death, either by necrosis or by apoptosis ... More


Death and survival in the nervous system

James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

in Brain Damage, Brain Repair

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198523376
eISBN:
9780191724534
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523376.003.0001
Subject:
Neuroscience, Techniques

It is only in recent years that we have come to realise how important is the part played by cell death in the development, homeostasis, and injury responses of the nervous system. During development ... More


Neurotrophic factors responsible for neuronal survival

Motoy Kuno

in The Synapse: Function, Plasticity, and Neurotrophism

Published in print:
1994
Published Online:
March 2012
ISBN:
9780198546870
eISBN:
9780191724350
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198546870.003.0144
Subject:
Neuroscience, Molecular and Cellular Systems

As Gutmann (1976) predicted, the analysis of neurotrophic mechanisms is easier if the nature of the trophic factor is known. Fortunately, several neurotrophic factors have been now identifed. This ... More


Metabolic damage

James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

in Brain Damage, Brain Repair

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198523376
eISBN:
9780191724534
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523376.003.0003
Subject:
Neuroscience, Techniques

Many conditions can cause metabolic damage to the CNS, and they do so through a variety of mechanisms. Stroke, for instance, causes anoxic damage to a region of the brain, the actual cell death being ... More


Alzheimer’s Disease—is it Caused by Cerebrovascular Dysfunction?

Christian Humpel

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0015
Subject:
Neuroscience, Molecular and Cellular Systems

Alzheimer's disease (AD) is a progressive chronic disorder characterized by β-amyloid plaques, tau pathology, cell death of cholinergic neurons, and inflammatory responses. The reasons for this ... More


Cancer

Robert L. Perlman

in Evolution and Medicine

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199661718
eISBN:
9780191774720
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199661718.003.0006
Subject:
Biology, Evolutionary Biology / Genetics

Cancer exemplifies the evolutionary theory of aging. The incidence of most cancers increases with age and more than half of all cancers are detected in people over 60. Evolution and selection can ... More


Neuroprotection

James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

in Brain Damage, Brain Repair

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198523376
eISBN:
9780191724534
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523376.003.0007
Subject:
Neuroscience, Techniques

Excitoxic damage, metabolic imbalance, oxidative stress, and calcium influx are each capable of inducing cell death by both necrotic and apoptotic mechanisms. If these various mechanisms contribute, ... More


Masakazu Konishi

Larry R. Squire

in The History of Neuroscience in Autobiography Volume 6

Published in print:
2009
Published Online:
May 2009
ISBN:
9780195380101
eISBN:
9780199864362
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195380101.003.0007
Subject:
Neuroscience, History of Neuroscience

This chapter presents an autobiography of Masakazu Konishi. Konishi has been one of the leaders in avian neuroethology since the early 1960's. He is known for his idea that young birds initially ... More


Trophic factors

James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

in Brain Damage, Brain Repair

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198523376
eISBN:
9780191724534
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523376.003.0009
Subject:
Neuroscience, Techniques

The developing nervous system produces about twice as many neurons as will survive into adulthood, and then at the end of development, around the time of birth in mammals, there is a short period ... More


Dying to Live

Karel Schrijiver and Iris Schrijiver

in Living with the Stars: How the Human Body is Connected to the Life Cycles of the Earth, the Planets, and the Stars

Published in print:
2015
Published Online:
April 2015
ISBN:
9780198727439
eISBN:
9780191793615
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198727439.003.0002
Subject:
Physics, Particle Physics / Astrophysics / Cosmology

This chapter shows how the human body maintains itself by balancing the death of cells with the creation of new ones. Every year of our lives we purge and regenerate a cell mass that is about as ... More


Countering Wear and Tear

Karel Schrijiver and Iris Schrijiver

in Living with the Stars: How the Human Body is Connected to the Life Cycles of the Earth, the Planets, and the Stars

Published in print:
2015
Published Online:
April 2015
ISBN:
9780198727439
eISBN:
9780191793615
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198727439.003.0003
Subject:
Physics, Particle Physics / Astrophysics / Cosmology

This chapter is at the heart of remaining healthy. When the body’s self-repair processes fail to function effectively, diseases emerge, in many cases because the balance between cell death and ... More


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