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Irreversible Discrete Disease Processes: Silica and Lung Cancer

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195141566
eISBN:
9780199872145
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141566.003.0015
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The introduction to discrete irreversible processes in Chapter 13 noted that there are two important examples of groups of diseases that follow this pattern: immune sensitization and carcinogenesis. ... More


Cancer biology

Peter Hoskin and Wendy Makin

in Oncology for Palliative Medicine

Published in print:
2003
Published Online:
November 2011
ISBN:
9780192628114
eISBN:
9780191730115
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192628114.003.0002
Subject:
Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology

Malignant cells differ from normal tissues in a number of fundamental properties. The malignancy in cells is a result of the changes in the genetic make-up of the cells. Changes in the sequences of ... More


Cancer as a microevolutionary process

Natalia L. Komarova and Dominik Wodarz

in Evolution in Health and Disease

Published in print:
2007
Published Online:
April 2010
ISBN:
9780199207466
eISBN:
9780191728167
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199207466.003.0022
Subject:
Biology, Evolutionary Biology / Genetics

Mathematical models of cancer evolution can provide helpful insights. This chapter describes a way to model cancer in which carcinogenesis is a microevolutionary process inside an organ. It uses both ... More


Pharmaceuticals Other Than Hormones

LAUREL A. HABEL and GARY D. FRIEDMAN

in Cancer Epidemiology and Prevention

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195149616
eISBN:
9780199865062
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195149616.003.0025
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses the link between therapeutic drugs and cancer. Topics covered include chemical carcinogenesis, drug safety, pharmacoepidemiologic studies, methodologic issues in studies of ... More


Genetic Epidemiology of Cancer

Christopher Haiman and David Hunter

in Textbook of Cancer Epidemiology

Published in print:
2008
Published Online:
September 2009
ISBN:
9780195311174
eISBN:
9780199865093
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195311174.003.0004
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Clarifying the complex etiologic role of environmental and genetic factors in carcinogenesis will be challenging but necessary to understand fully the causes of cancer and how it can be prevented. ... More


Hormones and Cancer

Robert N. Hoover, Amanda Black, and Rebecca Troisi

in Cancer Epidemiology and Prevention

Published in print:
2017
Published Online:
December 2017
ISBN:
9780190238667
eISBN:
9780190238698
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190238667.003.0022
Subject:
Public Health and Epidemiology, Epidemiology, Public Health

Hormones are highly biologically active endogenous compounds that control the growth, development, physiology, and homeostasis of numerous organ systems. Because of this, they have long been thought ... More


Momentum for Molecular Medicine

Robin Wolfe Scheffler

in A Contagious Cause: The American Hunt for Cancer Viruses and the Rise of Molecular Medicine

Published in print:
2019
Published Online:
January 2020
ISBN:
9780226458892
eISBN:
9780226628400
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226628400.003.0011
Subject:
History, History of Science, Technology, and Medicine

Chapter 10 explains how molecular approaches to cancer survived a period of political and cultural disillusionment in the late 1970s. Environmental and social approaches to the cancer problem ... More


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