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The Pharmacology of Delta-9-Tetrahydrocannabinol (THC), the Psychoactive Ingredient in Cannabis

Leslie L. Iversen

in The Science of Marijuana

Published in print:
2007
Published Online:
January 2010
ISBN:
9780195328240
eISBN:
9780199864751
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328240.003.0002
Subject:
Neuroscience, Sensory and Motor Systems

This chapter discusses the pharmacology of delta-9-tetrahydrocannabinol (THC). Topics covered include the isolation of THC from cannabis, man-made cannabinoids, cannabinoid antagonists, elimination ... More


Endocannabinoids

Leslie L. Iversen

in The Science of Marijuana

Published in print:
2007
Published Online:
January 2010
ISBN:
9780195328240
eISBN:
9780199864751
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328240.003.0003
Subject:
Neuroscience, Sensory and Motor Systems

This chapter begins with a discussion of the discovery of naturally occurring cannabinoids, known as endocannabinoids. It then discusses the biosynthesis and inactivation of endocannabinoids, the ... More


Methadone and other novel treatments for pain

Neil Hagen and Christopher Ralph

in Palliative Medicine: A case-based manual

Published in print:
2012
Published Online:
May 2012
ISBN:
9780199694143
eISBN:
9780191739255
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199694143.003.0031
Subject:
Palliative Care, Patient Care and End-of-Life Decision Making

This chapter presents a case study to show the necessary skills, attitudes, and background required to diagnose and manage cancer pain. It describes the use of three agents that have been employed in ... More


Cannabis Pharmacology

Mitch Earleywine

in Understanding Marijuana: A New Look at the Scientific Evidence

Published in print:
2003
Published Online:
April 2010
ISBN:
9780195138931
eISBN:
9780199893270
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195138931.003.0006
Subject:
Psychology, Psychopharmacology

Understanding marijuana's impact on biological systems requires a description of its active components. This chapter begins by identifying the mind-altering molecules in marijuana, the substances ... More


Cannabinoids in Clinical Practice: A UK Perspective

William Notcutt and Emily L. Clarke

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0022
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Medicinal-grade cannabinoids have been used in the UK since the introduction of nabilone in 1985 for chemotherapy-induced nausea and vomiting (CINV). The availability of Sativex® since 2000 has been ... More


Handbook of Cannabis

Roger Pertwee (ed.)

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.001.0001
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

This book provides a multifaceted account of cannabis, a plant that is used widely both recreationally and as a medicine, as it has been over many centuries. Thus, it presents a brief account of the ... More


Phytocannabinoids and the Gastrointestinal System

Marnie Duncan and Angelo A. Izzo

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0012
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

The plant Cannabis, which has been traditionally employed for the treatment of gastrointestinal ailments, contains both psychotropic phytocannabinoids, such as Δ‎9-tetrahydrocannabinol and ... More


Cannabinoid Pharmacokinetics and Disposition in Alternative Matrices

Marilyn A. Huestis and Michael L. Smith

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0016
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Knowledge of cannabinoid pharmacokinetics and cannabinoid disposition into biological fluids and tissues is essential to understanding the onset, magnitude, and duration of cannabinoid ... More


Established and Emerging Concepts of Cannabinoid Action on Food Intake and their Potential Application to the Treatment of Anorexia and Cachexia

Luigia Cristino and Vincenzo Di Marzo

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0024
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Appetite stimulation is one of the most often anecdotally documented actions of cannabis preparations used for recreational purposes. After the discovery of the cannabinoid CB1 and CB2 receptors for ... More


Phytocannabinoids in Degenerative and Inflammatory Retinal Diseases: Glaucoma, Age-Related Macular Degeneration, Diabetic Retinopathy, and Uveoretinitis

Heping Xu and Augusto Azuara-Blanco

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0033
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Glaucoma, diabetic retinopathy, age-related macular degeneration, and intraocular inflammation (uveoretinitis) are the major causes of blindness in developed countries. Although different diseases ... More


Harm Reduction Policies for Cannabis

Wayne Hall and Louisa Degenhardt

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0039
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Cannabinoid designer drugs are clandestinely synthesized structures that function as cannabinoid receptor agonists, are typically formulated as additives in smokable herbal mixtures with names such ... More


Constituents of Cannabis Sativa

Mahmoud A. ElSohly and Waseem Gul

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0001
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Cannabis (Cannabis sativa, or hemp) is an annual herbaceous plant belonging to the Cannabaceae family. This plant has been used for multiple purposes (medicinal, recreational, seed oil and industrial ... More


Endocannabinoids

Leslie Iversen

in The Science of Marijuana

Published in print:
2019
Published Online:
November 2018
ISBN:
9780190846848
eISBN:
9780190846879
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190846848.003.0004
Subject:
Psychology, Psychopharmacology

The endocannabinoids are part of a large family of lipid signaling molecules derived from arachidonic acid, including the prostaglandins and leukotrienes, which are important mediators of ... More


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