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Genetic Modifiers of Cancer Risk

NEIL E. CAPORASO

in Cancer Epidemiology and Prevention

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195149616
eISBN:
9780199865062
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195149616.003.0029
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses genetic modifiers of cancer risk. Topics covered include rationale for the study of low-penetrance genes, the role of low-penetrance genes in cancer susceptibility, ... More


Pigmentation and Candidate Gene Variation in Northern Island Melanesia

Heather L. Norton, George Koki, and Jonathan S. Friedlaender

in Population Genetics, Linguistics, and Culture History in the Southwest Pacific

Published in print:
2007
Published Online:
September 2007
ISBN:
9780195300307
eISBN:
9780199790142
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195300307.003.0006
Subject:
Biology, Evolutionary Biology / Genetics

This chapter reviews the skin and hair pigmentation variation across Northern Island Melanesia. Advanced reflectance instruments now allow for detection of considerable regional variation in ... More


Complex Phenotypes and the Use of Polygenic Scores to Investigate Gene × Environment Interactions for Substance Use

Michael Windle

in Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262034685
eISBN:
9780262335522
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262034685.003.0010
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

The chapter suggests the need of a “second-generation” candidate gene approach to adapt to first-generation limitations and to strengthen efforts to study GE interactions. The sample sizes associated ... More


Genetic Markers for Antisocial Behavior

Sharon Niv and Laura A. Baker

in The Origins of Antisocial Behavior: A Developmental Perspective

Published in print:
2012
Published Online:
March 2015
ISBN:
9780199753475
eISBN:
9780190255985
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:osobl/9780199753475.003.0001
Subject:
Psychology, Developmental Psychology

This chapter reviews research on genetic markers for antisocial behavior (ASB) and aggression. Following a brief description of the definition and scope of studies in ASB, the chapter summarizes the ... More


Gene–environment interaction in coronary artery disease: apolipoprotein E and smoking and the interleukin-6 gene and inflammation as examples

S. E. Humphries

in Coronary Heart Disease Epidemiology: From aetiology to public health

Published in print:
2005
Published Online:
September 2009
ISBN:
9780198525738
eISBN:
9780191724114
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198525738.003.0032
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses gene-environment interaction in coronary artery disease (CAD). Topics covered include risk factors for CAD, apolipoprotein E and effect on lipid levels and coronary heart ... More


Complex Traits in Natural Populations

Daniel L. Hartl

in A Primer of Population Genetics and Genomics

Published in print:
2020
Published Online:
August 2020
ISBN:
9780198862291
eISBN:
9780191895074
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198862291.003.0009
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies, Evolutionary Biology / Genetics

This chapter could as well be titled “Population Genomics,” although many aspects of population genomics are integrated throughout the other chapters. It includes estimates of mutational variance and ... More


Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Michael Pluess (ed.)

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686674
eISBN:
9780191766787
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686674.001.0001
Subject:
Psychology, Cognitive Psychology, Evolutionary Psychology

The science of psychological well-being has gained a lot of interest in the last decade. While it has been shown that psychological well-being is partly heritable, research focused on the ... More


Genetic Epidemiology of Cancer

Christopher Haiman and David J. Hunter

in Textbook of Cancer Epidemiology

Published in print:
2018
Published Online:
February 2018
ISBN:
9780190676827
eISBN:
9780190676858
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190676827.003.0004
Subject:
Public Health and Epidemiology, Epidemiology, Public Health

This chapter explores the genetic epidemiology of cancer: the identification and quantification of inherited genetic factors, and their potential interaction with the environment, in the etiology of ... More


Mechanisms of aging in human populations

Maris Kuningas and Rudi G.J. Westendorp

in Mechanisms of Life History Evolution: The Genetics and Physiology of Life History Traits and Trade-Offs

Published in print:
2011
Published Online:
December 2013
ISBN:
9780199568765
eISBN:
9780191774591
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199568765.003.0016
Subject:
Biology, Evolutionary Biology / Genetics

Ample evidence from model organisms has indicated that subtle variation in genes can dramatically influence lifespan. The key genes and molecular mechanisms that have been identified so far encode ... More


Genetics and Genomics

Andrew P. Hendry

in Eco-evolutionary Dynamics

Published in print:
2016
Published Online:
January 2018
ISBN:
9780691145433
eISBN:
9781400883080
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691145433.003.0010
Subject:
Biology, Ecology

This chapter focuses on common empirical methods for studying the genetics of adaptation: quantitative genetics, quantitative trait locus (QTL) linkage mapping, association mapping, genome scans, ... More


Genetics of emotion regulation: A systematic review

Andrei C Miu and Mirela I Bîlc

in Genes, brain, and emotions: Interdisciplinary and Translational Perspectives

Published in print:
2019
Published Online:
June 2019
ISBN:
9780198793014
eISBN:
9780191834745
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198793014.003.0011
Subject:
Neuroscience, Development, Disorders of the Nervous System

Research in the last decades has extensively supported the widespread involvement of emotion regulation (i.e. the processes by which one attempts to modulate the experience and expression of affect) ... More


Human Behavioral Genetics: Personality Studies, Depression, Gene-Environment Interplay, and the Revolutionary Results of GWAS

Kenneth F. Schaffner

in Behaving: What's Genetic, What's Not, and Why Should We Care?

Published in print:
2016
Published Online:
May 2016
ISBN:
9780195171402
eISBN:
9780190464103
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195171402.003.0007
Subject:
Philosophy, Philosophy of Science, Moral Philosophy

Chapter 6 discusses personality genetics, a revisited "novelty-seeking gene" (DRD4), as well as two important "trait theories" of personality: Cloninger's theory and the five-factor model. The ... More


Genes as a Source of Risk for Mental Disorders

Peter P. Zandi, Holly C. Wilcox, Yian Lin, Brion Maher, and M. Daniele Fallin

in Public Mental Health

Published in print:
2019
Published Online:
June 2019
ISBN:
9780190916602
eISBN:
9780190916640
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190916602.003.0010
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter introduces the reader to the concept of genetics and disease and includes review of more than 200 family, twin, and adoption studies for six important mental and behavioral disorders. ... More


Multilocus evolution

Glenn-Peter Sætre and Mark Ravinet

in Evolutionary Genetics: Concepts, Analysis, and Practice

Published in print:
2019
Published Online:
July 2019
ISBN:
9780198830917
eISBN:
9780191868993
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198830917.003.0006
Subject:
Biology, Evolutionary Biology / Genetics, Biomathematics / Statistics and Data Analysis / Complexity Studies

Most phenotypic traits are affected by a multitude of genes, which may interact in complex ways. This means that the single locus model explored in chapters 3 and 4 is not always able to capture the ... More


An Introduction to Text Analysis in Genomics

Soumya Raychaudhuri

in Computational Text Analysis: for functional genomics and bioinformatics

Published in print:
2006
Published Online:
November 2020
ISBN:
9780198567400
eISBN:
9780191916700
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198567400.003.0008
Subject:
Computer Science, Mathematical Theory of Computation

The February 16th, 2001 issue of Science magazine announced the completion of the human genome project—making the entire nucleotide sequence of the genome available ... More


The heritability and genetics of optimism, spirituality, and meaning in life

Elaine Fox and Charlotte Booth

in Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686674
eISBN:
9780191766787
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686674.003.0008
Subject:
Psychology, Cognitive Psychology, Evolutionary Psychology

Optimism, spirituality, and a sense of meaning in life are all considered to be critical components of an individual’s character. This chapter examines the degree to which these character traits are ... More


Maternal Effects in Wild Ungulates

Alastair J. Wilson and Marco Festa-Bianchet

in Maternal Effects in Mammals

Published in print:
2009
Published Online:
February 2013
ISBN:
9780226501192
eISBN:
9780226501222
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226501222.003.0005
Subject:
Biology, Animal Behavior / Behavioral Ecology

This chapter reviews the evidence for maternal effects in wild ungulate populations, discussing their prevalence and the mechanisms by which they are mediated. The analysis reveals that maternal ... More


From pleasure to liking and back: Bottom-up and top-down neural routes to the aesthetic enjoyment of music

Elvira Brattico

in Art, Aesthetics, and the Brain

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199670000
eISBN:
9780191793479
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199670000.003.0015
Subject:
Psychology, Cognitive Psychology, Social Psychology

This chapter analyses the neural mechanisms that generate the aesthetic emotion of musical enjoyment. First, it focuses on the bottom-up succession of neural events from the periphery to the central ... More


Rare Variant Approaches to Understanding the Causes of Complex Neuropsychiatric Disorders

Matthew W. State

in Causality and Psychopathology: Finding the Determinants of Disorders and their Cures

Published in print:
2011
Published Online:
November 2020
ISBN:
9780199754649
eISBN:
9780197565650
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199754649.003.0015
Subject:
Clinical Medicine and Allied Health, Psychiatry

The distinction between genetic variation that is present in more than 5% of the population (defined as common) and genetic variation that does not meet ... More


What Causes Primary Psychotic Disorders Like Schizophrenia?

Michael T Compton and Beth Broussard

in The First Episode of Psychosis: A Guide for Patients and Their Families

Published in print:
2010
Published Online:
November 2020
ISBN:
9780195372496
eISBN:
9780197562659
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195372496.003.0012
Subject:
Clinical Medicine and Allied Health, Psychiatry

Doctors and researchers have been able to identify the causes of a variety of medical conditions, such as the common cold, a heart attack, and gout, to ... More


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