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Cell death

Baltazar D. Aguda and Avner Friedman

in Models of Cellular Regulation

Published in print:
2008
Published Online:
September 2008
ISBN:
9780198570912
eISBN:
9780191718717
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198570912.003.0008
Subject:
Physics, Soft Matter / Biological Physics

Apoptosis or programmed cell death is the mechanism that cells employ to eliminate cells with irreparably damaged DNA. Abnormalities in the regulation of apoptosis have been implicated in the origins ... More


Protein Misfolding, Mitochondrial Disturbances, And Kynurenines In The Pathogenesis Of Neurodegenerative Disorders

Gabriella Gárdián, Katalin Sas, József Toldi, and László Vécsei

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0018
Subject:
Neuroscience, Molecular and Cellular Systems

As a population ages, neurodegenerative diseases become increasingly prevalent. These are different clinical entities, though they display many common features in their clinical, biochemical, and ... More


Cell Death

Stevens K. Rehen and Jerold J.M. Chun

in Brain Development: Normal Processes and the Effects of Alcohol and Nicotine

Published in print:
2006
Published Online:
January 2010
ISBN:
9780195183139
eISBN:
9780199865147
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195183139.003.0005
Subject:
Neuroscience, Development

The importance of cell death in the formation of the central nervous system has become well established over the past several decades. Understanding cell death in the developing brain is one of the ... More


Molecular Responses to Asbestos: Induction of Cell Proliferation and Apoptosis Through Modulation of Redox-Dependent Cell Signaling Pathways

Nicholas H. Heintz and Brooke T. Mossman

in Asbestos and Its Diseases

Published in print:
2008
Published Online:
September 2009
ISBN:
9780195178692
eISBN:
9780199864591
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195178692.003.0005
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses how asbestos interacts with cell-signaling pathways to modulate cell functions, including induction of proliferation and cell death, either by necrosis or by apoptosis ... More


Retention of Function in the Aged Brain:: The Pivotal Role of β-Amyloid

Carl W. Cotman and Aileen J. Anderson

in Brain and Memory: Modulation and Mediation of Neuroplasticity

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195082944
eISBN:
9780199847877
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082944.003.0008
Subject:
Psychology, Cognitive Neuroscience

This chapter describes the basic deficits in learning and memory observed in Alzheimer's disease (AD), along with the functional disconnection of cortical-hippocampal circuitry associated with its ... More


Inducible Aromatase in Astroglia: Protection and Recovery from Neural Perturbation in Birds

Kelli A. Duncan and Colin J. Saldanha

in Brain Aromatase, Estrogens, and Behavior

Published in print:
2012
Published Online:
January 2013
ISBN:
9780199841196
eISBN:
9780199979837
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199841196.003.0020
Subject:
Neuroscience, Neuroendocrine and Autonomic

In the avian brain, aromatase is constitutive and inducible in neurons and glia respectively. Glial aromatase is rapidly and dramatically upregulated in astroglia (astrocytes and radial glia) ... More


Remodeling the Adolescent Brain: What’s in the Toolbox?

Cheryl L. Sisk and Russell D. Romeo

in Coming of Age: The Neurobiology and Psychobiology of Puberty and Adolescence

Published in print:
2019
Published Online:
July 2020
ISBN:
9780195314373
eISBN:
9780197507094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195314373.003.0003
Subject:
Psychology, Cognitive Neuroscience, Developmental Psychology

Chapter 3 covers the basic neural mechanisms by which the brain undergoes an extreme makeover during adolescence. It starts with the proposition that the nervous system has only so many tools in the ... More


Methods to Identify Cellular Architecture and Dynamics from Experimental Data

Rudiyanto Gunawan, Kapil G. Gadkar, and Francis J. Doyle

in System Modeling in Cellular Biology: From Concepts to Nuts and Bolts

Published in print:
2006
Published Online:
August 2013
ISBN:
9780262195485
eISBN:
9780262257060
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262195485.003.0011
Subject:
Mathematics, Mathematical Biology

This chapter highlights the methodologies and challenges in the reverse engineering of cellular networks, in particular the identification of network dynamics using engineering approaches. The ... More


‘Du mort qui saisit le vif’: Simondonian Ontology Today1

Jean-Hugues Barthélémy and Justin Clemens

in Gilbert Simondon: Being and Technology

Published in print:
2013
Published Online:
September 2013
ISBN:
9780748677214
eISBN:
9780748684489
Item type:
chapter
Publisher:
Edinburgh University Press
DOI:
10.3366/edinburgh/9780748677214.003.0007
Subject:
Philosophy, Metaphysics/Epistemology

Since the guiding thread and the priority of Simondon's entire ontology consist in trying to overcome classical oppositions such as the one between vitalism and mechanism, and between sociologism and ... More


A Processual Perspective on Cancer

Marta Bertolaso and John Dupré

in Everything Flows: Towards a Processual Philosophy of Biology

Published in print:
2018
Published Online:
July 2018
ISBN:
9780198779636
eISBN:
9780191824685
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198779636.003.0016
Subject:
Philosophy, Philosophy of Science, Metaphysics/Epistemology

This chapter attempts to illuminate the dynamic stability of the organism and the robustness of its developmental pathway by considering the biology of cancer. Healthy development and stable ... More


Cancer

Guillermo Velasco, Cristina Sánchez, and Manuel Guzmán

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0035
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

A large body of evidence shows that cannabinoids, in addition to their well-known palliative effects on some cancer-associated symptoms, can reduce tumor growth in animal models of cancer. They do so ... More


Oxidative stress and redox regulation: adaptation, damage, repair, senescence, and death

Barry Halliwell and John M.C. Gutteridge

in Free Radicals in Biology and Medicine

Published in print:
2015
Published Online:
October 2015
ISBN:
9780198717478
eISBN:
9780191802133
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198717478.003.0005
Subject:
Biology, Biochemistry / Molecular Biology, Disease Ecology / Epidemiology

This chapter defines the terms oxidative stress and oxidative damage, and explains how they can affect cell behaviour: proliferation, adaptation, injury, senescence, intercellular communication, and ... More


General Otolaryngology

Stuart Winter and Declan Costello (eds)

in MCQs for ENT: Preparation for the FRCS (ORL-HNS)

Published in print:
2019
Published Online:
November 2020
ISBN:
9780198792000
eISBN:
9780191917110
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198792000.003.0012
Subject:
Clinical Medicine and Allied Health, Professional Development in Medicine

Questions Muscular innervation anatomy Oculomotor nerve Trochlear nerve Trigeminal nerve Abducens nerve Facial nerve Audiovestibular nerve Glossopharyngeal nerve Vagus nerve Accessory ... More


Paclitaxel (Taxol)

Jie Jack Li

in Top Drugs: Their History, Pharmacology, and Syntheses

Published in print:
2015
Published Online:
November 2020
ISBN:
9780199362585
eISBN:
9780197562918
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199362585.003.0009
Subject:
Chemistry, Medicinal Chemistry

Cancer is a disease of cellular dysfunction involving a range of biological activities that promote unregulated proliferation. It is as old as the existence of animals— cancers are found even in ... More


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