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What’s Wrong with Their Mice?

Nikolas Rose and Joelle M. Abi-Rached

in Neuro: The New Brain Sciences and the Management of the Mind

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691149608
eISBN:
9781400846337
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691149608.003.0004
Subject:
Neuroscience, Development

This chapter discusses the use of animals to explore issues relating to human cognition, emotion, volition, and their pathologies. Researchers who use animal models in their work point to ... More


Across the Boundaries: Extrapolation in Biology and Social Science

Daniel Steel

Published in print:
2007
Published Online:
January 2008
ISBN:
9780195331448
eISBN:
9780199868063
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195331448.001.0001
Subject:
Philosophy, Philosophy of Science

The biological and social sciences often generalize causal conclusions from one context to others that may differ in some relevant respects, as is illustrated by inferences from animal models to ... More


Spontaneous and engineered mammalian storage disease models

John J. Hopwood, Allison C. Crawley, and Rosanne M. Taylor

in Lysosomal Disorders of the Brain: Recent Advances in Molecular and Cellular Pathogenesis and Treatment

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198508786
eISBN:
9780191723803
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198508786.003.0011
Subject:
Neuroscience, Disorders of the Nervous System

Lysosomal storage disorders are inherited disorders of lysosomal organelle dysfunction. The relative rarity of storage diseases, their broad heterogeneous clinical presentation, and varied genetic ... More


Do animals have tinnitus?

Jos J. Eggermont

in The Neuroscience of Tinnitus

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199605606
eISBN:
9780191741555
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199605606.003.0005
Subject:
Neuroscience, Sensory and Motor Systems, Development

A positive answer to this question will allow in detail investigation of neural substrates at the single neuron and population level underlying tinnitus. Several behavioral models have been developed ... More


The Neuroscience of Tinnitus

Jos J. Eggermont

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199605606
eISBN:
9780191741555
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199605606.001.0001
Subject:
Neuroscience, Sensory and Motor Systems, Development

This book examines tinnitus from the viewpoint of a neuroscientist with a long background in translational research. Therefore the book focuses on the understanding of the mechanisms that underlie ... More


Managing Brains, Minds, and Selves

Nikolas Rose and Joelle M. Abi-Rached

in Neuro: The New Brain Sciences and the Management of the Mind

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691149608
eISBN:
9781400846337
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691149608.003.0009
Subject:
Neuroscience, Development

This concluding chapter suggests that for the human sciences, there is nothing to fear in the rise to prominence of neurobiological attempt to understand and account for human behavior. It is ... More


Memory and epilepsy in nonhuman animals

Pierre-Pascal J. Lenck-Santini and Gregory L. Holmes

in Epilepsy and Memory

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199580286
eISBN:
9780191739408
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199580286.003.0019
Subject:
Neuroscience, Disorders of the Nervous System, Behavioral Neuroscience

This chapter reviews neurophysiological studies of the effects of seizures on cognition in nonhuman animals. Animal models have contributed extensively to our understanding of the consequences of ... More


Exploring Declarative Memory using Animal Models

Howard Eichenbaum

in The Cognitive Neuroscience of Memory: An Introduction

Published in print:
2011
Published Online:
May 2012
ISBN:
9780199778614
eISBN:
9780199932962
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199778614.003.0005
Subject:
Neuroscience, Behavioral Neuroscience, Molecular and Cellular Systems

This chapter reviews evidence from animal models of amnesia. The efforts to model amnesia associated with damage to the medial temporal lobe followed two parallel approaches, one using monkeys as the ... More


Inhibition of substrate synthesis: a pharmacological approach for glycosphingolipid storage disease therapy

Frances M. Platt and Terry D. Butters

in Lysosomal Disorders of the Brain: Recent Advances in Molecular and Cellular Pathogenesis and Treatment

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198508786
eISBN:
9780191723803
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198508786.003.0015
Subject:
Neuroscience, Disorders of the Nervous System

The neuronopathic lysosomal storage diseases are not currently amenable to therapy due to the difficulties of delivering functional enzyme/protein to the brain. Over two decades ago, an alternative ... More


Depression Seen Through an Animal Model: An Expanded Hypothesis of Pathophysiology and Improved Models

Jay M. Weiss, Melissa K. Demetrikopoulos, Paige M. Mccurdy, Charles H. K. West, and Robert W. Bonsall

in Anxiety, Depression, and Emotion

Published in print:
2000
Published Online:
March 2012
ISBN:
9780195133585
eISBN:
9780199847310
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195133585.003.0001
Subject:
Psychology, Clinical Psychology

This chapter begins with a description of the animal model for the study of depression which focuses on stress-induced behavioral depression. Based on laboratory tests, etiological similarities ... More


Validating animal models of metacognition

Jonathon D. Crystal

in Foundations of Metacognition

Published in print:
2012
Published Online:
January 2013
ISBN:
9780199646739
eISBN:
9780191745867
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199646739.003.0003
Subject:
Psychology, Cognitive Psychology, Developmental Psychology

The comparative analysis of metacognition is a pathway towards uncovering fundamental information about the evolution of mind. A substantial amount of research has been directed towards this goal in ... More


Neural Control of Locomotion

Gerta Vrbová, Urszula Sławin´ska, and Henryk Majczyn´ski

in Restorative Neurology of Spinal Cord Injury

Published in print:
2011
Published Online:
January 2012
ISBN:
9780199746507
eISBN:
9780199918768
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199746507.003.0004
Subject:
Neuroscience, Sensory and Motor Systems, Disorders of the Nervous System

This chapter presents animal models of spinal cord injury (SCI) and discusses how an understanding of the mechanisms responsible for producing the locomotor pattern, rhythmic limb movements ... More


Extrapolation and Heterogeneity

Daniel P. Steel

in Across the Boundaries: Extrapolation in Biology and Social Science

Published in print:
2007
Published Online:
January 2008
ISBN:
9780195331448
eISBN:
9780199868063
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195331448.003.0001
Subject:
Philosophy, Philosophy of Science

This chapter introduces the general methodological challenges that confront extrapolation in the biological and social sciences, and sketches the outlines of the mechanisms approach to those ... More


Cross-Species Imaging Applied to the Aging Brain: Dissociating Alzheimer’s Disease from Normal Aging

Sidonie T. Jones and Scott A. Small

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0008
Subject:
Neuroscience, Techniques, Development

Whether ‘cognitive aging’ and Alzheimer's disease are overlapping processes or whether they are mechanistically distinct has been an ongoing debate. Indeed, both the early stages of Alzheimer's ... More


Retinal Cellular Metabolism and its Regulation and Control

Dao-Yi Yu, Stephen J Cringle, Paula K Yu, Er-Ning Su, Xinghuai Sun, Wenyi Guo, William H Morgan, Xiao-Bo Yu, and Chandrakumar Balaratnasingam

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0004
Subject:
Neuroscience, Molecular and Cellular Systems

The retina is an extension of the brain with a high functional activity and high metabolic rate but with only a limited blood supply. Consequently there is a delicate balance between high metabolic ... More


Episodic-like memory in animals: psychological criteria, neural mechanisms and the value of episodic-like tasks to investigate animal models of neurodegenerative disease

Richard G. M. Morris

in Episodic Memory: New Directions in Research

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198508809
eISBN:
9780191687396
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198508809.003.0011
Subject:
Psychology, Cognitive Psychology

The question of whether any non-human species displays episodic memory is controversial. Associative accounts of animal learning recognize that behaviour can change in response to single events but ... More


Migraine: A Spectrum of Ideas

Merton Sandler and Geralyn M. Collins (eds)

Published in print:
1990
Published Online:
March 2012
ISBN:
9780192618108
eISBN:
9780191724305
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192618108.001.0001
Subject:
Neuroscience, Disorders of the Nervous System

Thirty per cent of all women and ten per cent of all men experience migraine. This crippling illness does not kill, but its high morbidity poses a massive economic problem and gives rise to ... More


The Evolutionary Basis for Animal Research

Stephen P. Schiffer

in The Ethics of Animal Research: Exploring the Controversy

Published in print:
2012
Published Online:
August 2013
ISBN:
9780262017060
eISBN:
9780262301602
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262017060.003.0003
Subject:
Biology, Bioethics

This chapter reports that there is clear public support for ethically guided animal research and seeks to articulate a scientific basis for this intuition using the theory of evolution. It states ... More


Between Animality and Divinity

Nicolas Langlitz

in Neuropsychedelia: The Revival of Hallucinogen Research since the Decade of the Brain

Published in print:
2012
Published Online:
September 2013
ISBN:
9780520274815
eISBN:
9780520954908
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520274815.003.0006
Subject:
Anthropology, Medical Anthropology

Chapter 5, “Between Animality and Divinity,” takes the reader from Switzerland to California and from human to animal research. Difficulties in the translation between human- and animal-model ... More


Animal models

Eric T. Harvill and Tracy Nicholson

in Pertussis: Epidemiology, Immunology, and Evolution

Published in print:
2018
Published Online:
February 2019
ISBN:
9780198811879
eISBN:
9780191850011
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198811879.003.0006
Subject:
Biology, Disease Ecology / Epidemiology, Evolutionary Biology / Genetics

There is a long history of the study of Bordetella species in animal hosts, built on the foundation of Koch’s postulates: experimentally inoculating animals with virulent bacteria to define various ... More


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