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Using ancestral gene resurrection to unravel the evolution of protein function

Joseph W. Thornton and Jamie T. Bridgham

in Ancestral Sequence Reconstruction

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.003.0016
Subject:
Biology, Evolutionary Biology / Genetics

This chapter reviews the use of ancestral gene resurrection to understand how the members of a biologically crucial gene family, the steroid hormone receptors, evolved their diverse and highly ... More


Dealing with model uncertainty in reconstructing ancestral proteins in the laboratory: examples from archosaur visual pigments and coralfluorescent proteins

Belinda S.W. Chang, Mikhail V. Matz, Steven F. Field, Johannes Müller, and Ilke van Hazel

in Ancestral Sequence Reconstruction

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.003.0015
Subject:
Biology, Evolutionary Biology / Genetics

This chapter discusses efficient experimental strategies to explore variation in ancestral sequence reconstructions. The experimental strategies are illustrated with two examples, ancestral ... More


Evolutionary properties of sequences and ancestral state reconstruction

Lesley J. Collins and Peter J. Lockhart

in Ancestral Sequence Reconstruction

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.003.0009
Subject:
Biology, Evolutionary Biology / Genetics

A number of authors have recently stressed the importance of understanding the evolution of protein-protein interactions as an underlying cause of covarion-like patterns of evolution in ancestral ... More


Conclusion and a way forward

David A. Liberles

in Ancestral Sequence Reconstruction

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.003.0020
Subject:
Biology, Evolutionary Biology / Genetics

This concluding chapter discusses the various issues raised in the course of the book and suggests a way forward for readers attempting ancestral sequence reconstruction. Ancestral sequence ... More


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