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Introduction

Joachim Frank

in Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State

Published in print:
2006
Published Online:
April 2010
ISBN:
9780195182187
eISBN:
9780199893416
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195182187.003.0001
Subject:
Biology, Biochemistry / Molecular Biology

This introductory chapter begins with an appreciation of the unique position of electron microscopy in biological research as it bridges a wide gap between X-ray crystallography and light microscopy. ... More


Crystallography in the study of protein–DNA interaction

Maninder K. Sohi and Ivan Laponogov

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0015
Subject:
Biology, Biochemistry / Molecular Biology

In the living cell, protein-DNA interactions take place during genetic processes such as chromatin organization, recombination, replication, transcription, and DNA repair. In order to fully ... More


Crystals, X-rays and Proteins: Comprehensive Protein Crystallography

Dennis Sherwood and Jon Cooper

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199559046
eISBN:
9780191595028
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199559046.001.0001
Subject:
Physics, Crystallography: Physics

This book presents a complete account of the theory of the diffraction of X-rays by crystals with particular reference to the processes of determining the structures of protein molecules. The book ... More


William and Lawrence Bragg, Father and Son: The Most Extraordinary Collaboration in Science

John Jenkin

Published in print:
2007
Published Online:
January 2008
ISBN:
9780199235209
eISBN:
9780191715631
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199235209.001.0001
Subject:
Physics, History of Physics

This book describes how Lawrence and William Bragg, son and father, invented, developed, and led the scientific field of X-ray crystallography for fifty years, transforming much of modern science. ... More


Max Perutz and the SPSL

Georgina Ferry

in In Defence of Learning: The Plight, Persecution, and Placement of Academic Refugees, 1933-1980s

Published in print:
2011
Published Online:
January 2013
ISBN:
9780197264812
eISBN:
9780191754029
Item type:
chapter
Publisher:
British Academy
DOI:
10.5871/bacad/9780197264812.003.0006
Subject:
Sociology, Migration Studies (including Refugee Studies)

This chapter focuses on Austrian-born molecular biologist Max Perutz (1914–2002). Perutz was one of twenty scientific refugees from continental Europe who went on to win Nobel Prizes. A chemist and ... More


Analytical techniques for studying and characterizing polymorphs

Joel Bernstein

in Polymorphism in Molecular Crystals

Published in print:
2007
Published Online:
January 2010
ISBN:
9780199236565
eISBN:
9780191707940
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199236565.003.0004
Subject:
Physics, Crystallography: Physics

This chapter reviews the variety of analytical methods used in the investigation and characterization of molecular solids in general, and varieties of crystal forms in particular. The fundamental ... More


Conceiving a Master Molecule

Jan Sapp

in Genesis: The Evolution of Biology

Published in print:
2003
Published Online:
September 2007
ISBN:
9780195156195
eISBN:
9780199790340
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195156195.003.0016
Subject:
Biology, Evolutionary Biology / Genetics

This chapter focuses on the discovery of DNA. The discovery of DNA as the basis of the gene, how it is reproduced, and how it affects protein synthesis was the pinnacle of life sciences in the 20th ... More


Peering Inside Proteins

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0007
Subject:
Public Health and Epidemiology, Public Health

This chapter examines why some proteins are more susceptible to modulation by small molecule drugs than other proteins. To this end, the chapter presents an atom-by-atom picture of proteins and where ... More


William Lawrence Bragg (In his own Words)

A.M. Glazer and Patience Thomson

in Crystal Clear: The Autobiographies of Sir Lawrence and Lady Bragg

Published in print:
2015
Published Online:
August 2015
ISBN:
9780198744306
eISBN:
9780191805721
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198744306.003.0002
Subject:
Physics, Crystallography: Physics, History of Physics

This chapter contains William Lawrence Bragg (WLB)’s recollection of his life, starting with a description of his early boyhood growing up in Adelaide, Australia, and his family’s move to England. It ... More


Early Days of X-ray Crystallography

André Authier

Published in print:
2013
Published Online:
September 2013
ISBN:
9780199659845
eISBN:
9780191748219
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199659845.001.0001
Subject:
Physics, Crystallography: Physics

2012 marked the centenary of one of the most significant discoveries of the early twentieth century: the discovery of X-ray diffraction in March 1912 by Laue, Friedrich, and Knipping, and of the ... More


Hemoglobin structure and allosteric mechanism

Jay F. Storz

in Hemoglobin: Insights into protein structure, function, and evolution

Published in print:
2018
Published Online:
December 2018
ISBN:
9780198810681
eISBN:
9780191847929
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198810681.003.0004
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

Chapter 4 provides an overview of hemoglobin structure and explains the mechanistic basis of ligand-binding dynamics and allosteric effects. The chapter provides an overview of decades of research on ... More


Introduction

Eaton E. Lattman, Thomas D. Grant, and Edward H. Snell

in Biological Small Angle Scattering: Theory and Practice

Published in print:
2018
Published Online:
September 2018
ISBN:
9780199670871
eISBN:
9780191749575
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199670871.003.0001
Subject:
Physics, Soft Matter / Biological Physics

This chapter provides an introduction to small angle solution scattering with particular reference to the complementary technique of X-ray crystallography and the relationship between the two. It ... More


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