William Muraskin
- Published in print:
- 2017
- Published Online:
- September 2017
- ISBN:
- 9781526110886
- eISBN:
- 9781526124272
- Item type:
- chapter
- Publisher:
- Manchester University Press
- DOI:
- 10.7228/manchester/9781526110886.003.0013
- Subject:
- History, History of Science, Technology, and Medicine
I have intensively focused on the International Task Force on Hepatitis B Immunisation – led by James Maynard, Alfred Prince and Richard Mahoney; the Children’s Vaccine Initiative led by or ...
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I have intensively focused on the International Task Force on Hepatitis B Immunisation – led by James Maynard, Alfred Prince and Richard Mahoney; the Children’s Vaccine Initiative led by or influenced by Scott Halstead, Philip Russell and Roy Widdus; the Bill and Melinda Gates’ Children’s Vaccine Programme led by Mark Kane and James Maynard; the Global Alliance for Vaccines and Immunization created by Mark Kane, Tore Godal, Jacques-Francois Martin, Steve Landry and Amy Bateson; the Rockefeller Foundation’s Public-Private Partnership project single-handedly championed by Ariel Pablos-Mendez (with the support of Timothy Evans) – many of which were ultimately adopted by the Gates Foundation and (incorrectly) seen as originating with it; and the global polio eradication campaign conceived by William Foege, Alan Hinman, Ciro de Quadros and run by Bruce Alyward.
Driven by a powerful moral imperative and social consciousness, these dozen and a half men fought to make things happen that under normal circumstances would not have happened in the fight to save the lives of countless children using vaccines and immunisation as their tools.
Among their supporters have been many engaged and committed vaccine champions within the scientific community: scientist/activists working for what they believed was clearly the ‘Greater Good’.Less
I have intensively focused on the International Task Force on Hepatitis B Immunisation – led by James Maynard, Alfred Prince and Richard Mahoney; the Children’s Vaccine Initiative led by or influenced by Scott Halstead, Philip Russell and Roy Widdus; the Bill and Melinda Gates’ Children’s Vaccine Programme led by Mark Kane and James Maynard; the Global Alliance for Vaccines and Immunization created by Mark Kane, Tore Godal, Jacques-Francois Martin, Steve Landry and Amy Bateson; the Rockefeller Foundation’s Public-Private Partnership project single-handedly championed by Ariel Pablos-Mendez (with the support of Timothy Evans) – many of which were ultimately adopted by the Gates Foundation and (incorrectly) seen as originating with it; and the global polio eradication campaign conceived by William Foege, Alan Hinman, Ciro de Quadros and run by Bruce Alyward.
Driven by a powerful moral imperative and social consciousness, these dozen and a half men fought to make things happen that under normal circumstances would not have happened in the fight to save the lives of countless children using vaccines and immunisation as their tools.
Among their supporters have been many engaged and committed vaccine champions within the scientific community: scientist/activists working for what they believed was clearly the ‘Greater Good’.
Mario Roederer and Stephen C. De Rosa
- Published in print:
- 2005
- Published Online:
- November 2020
- ISBN:
- 9780195183146
- eISBN:
- 9780197561898
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/oso/9780195183146.003.0015
- Subject:
- Chemistry, Physical Chemistry
Fluorescence-based flow cytometry was introduced in the late 1960s and is now used extensively both in basic research and in the clinic. Flow cytometry ...
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Fluorescence-based flow cytometry was introduced in the late 1960s and is now used extensively both in basic research and in the clinic. Flow cytometry allows not only for the rapid multiparametric analysis of cells on a cell-by-cell basis but also for the viable separation, or sorting, of highly purified populations of cells. In this chapter, we will discuss only the analysis aspects. The earliest flow cytometry experiments had three parameters: one fluorescence measurement and two scattered light signals. An early “one-color” experiment successfully separated antibody-secreting B cells from mouse splenocytes. This and other early studies quickly demonstrated the usefulness of this technology in immunological studies. However, measurement of only one fluorescence was a limitation. By adding detectors collecting light in specified wavelength ranges, multiple fluorescence measurements could be made simultaneously. By 1984, four-color fluorescence experiments could be routinely performed, at least in the most sophisticated flow cytometry laboratories, but it took another 10 years before most laboratories could perform routine three-color experiments. One reason for this delay is that it took some time to recognize the need for measuring multiple parameters in addressing questions that explored the complexity of the immune system. Another reason was that it was not until the late 1980s that fourcolor benchtop instrumentation became available. The AIDS epidemic also had a major effect on the expansion of flow cytometry into the research community, as early in the epidemic, the enumeration of CD4 was found to serve as a surrogate marker for disease progression. During this period, we were examining a number of functionally-important T cell subsets in HIV-infected adults and children, including naïve and memory, using three-color flow cytometry. These studies demonstrated clearly for the first time the loss of both CD4 and CD8 naïve T cells during HIV disease progression. This loss had not been previously recognized either because appropriate combinations of reagents were not used or because the studies were limited to two colors. Having demonstrated that multiple markers used in combination could lead to clinically relevant findings that were previously missed, we wondered how many other important subsets could be detected by measuring additional parameters.
Less
Fluorescence-based flow cytometry was introduced in the late 1960s and is now used extensively both in basic research and in the clinic. Flow cytometry allows not only for the rapid multiparametric analysis of cells on a cell-by-cell basis but also for the viable separation, or sorting, of highly purified populations of cells. In this chapter, we will discuss only the analysis aspects. The earliest flow cytometry experiments had three parameters: one fluorescence measurement and two scattered light signals. An early “one-color” experiment successfully separated antibody-secreting B cells from mouse splenocytes. This and other early studies quickly demonstrated the usefulness of this technology in immunological studies. However, measurement of only one fluorescence was a limitation. By adding detectors collecting light in specified wavelength ranges, multiple fluorescence measurements could be made simultaneously. By 1984, four-color fluorescence experiments could be routinely performed, at least in the most sophisticated flow cytometry laboratories, but it took another 10 years before most laboratories could perform routine three-color experiments. One reason for this delay is that it took some time to recognize the need for measuring multiple parameters in addressing questions that explored the complexity of the immune system. Another reason was that it was not until the late 1980s that fourcolor benchtop instrumentation became available. The AIDS epidemic also had a major effect on the expansion of flow cytometry into the research community, as early in the epidemic, the enumeration of CD4 was found to serve as a surrogate marker for disease progression. During this period, we were examining a number of functionally-important T cell subsets in HIV-infected adults and children, including naïve and memory, using three-color flow cytometry. These studies demonstrated clearly for the first time the loss of both CD4 and CD8 naïve T cells during HIV disease progression. This loss had not been previously recognized either because appropriate combinations of reagents were not used or because the studies were limited to two colors. Having demonstrated that multiple markers used in combination could lead to clinically relevant findings that were previously missed, we wondered how many other important subsets could be detected by measuring additional parameters.
Shannon L. Mariotti
- Published in print:
- 2016
- Published Online:
- January 2017
- ISBN:
- 9780813167336
- eISBN:
- 9780813167411
- Item type:
- chapter
- Publisher:
- University Press of Kentucky
- DOI:
- 10.5810/kentucky/9780813167336.003.0007
- Subject:
- Political Science, Political Theory
This chapter shows how Adorno identifies small-scale, modest, less visible “substantive democratic forms” in the United States that act as countertendencies that might be drawn out as a vaccine ...
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This chapter shows how Adorno identifies small-scale, modest, less visible “substantive democratic forms” in the United States that act as countertendencies that might be drawn out as a vaccine against more prevalent fascistic elements of pseudo-democracy in America. In his writings on American culture, we see Adorno employing the same mode of critique that Marx applies to the commodity, but with a different object: Adorno’s critique is directed toward an exploration of the radio or the Los Angeles Times’s astrology column, for example, as microcosms of the larger modern capitalist culture in the United States. But Adorno aims to illuminate how even seemingly insignificant cultural objects actually contain important nonidentical qualities—countertendencies—that protest against and can be used to unsettle the problematic conditions that they otherwise participate in and uphold. Adorno’s writings on American culture must be read in terms of his theory and practice of negative dialectics for our picture of him to avoid the problematic distortions it has been subjected to in the past. In this way, Adorno sees the potential for change—what might be—arising from the tensions and contradictions—the countertendencies—that exist within a problematic status quo.Less
This chapter shows how Adorno identifies small-scale, modest, less visible “substantive democratic forms” in the United States that act as countertendencies that might be drawn out as a vaccine against more prevalent fascistic elements of pseudo-democracy in America. In his writings on American culture, we see Adorno employing the same mode of critique that Marx applies to the commodity, but with a different object: Adorno’s critique is directed toward an exploration of the radio or the Los Angeles Times’s astrology column, for example, as microcosms of the larger modern capitalist culture in the United States. But Adorno aims to illuminate how even seemingly insignificant cultural objects actually contain important nonidentical qualities—countertendencies—that protest against and can be used to unsettle the problematic conditions that they otherwise participate in and uphold. Adorno’s writings on American culture must be read in terms of his theory and practice of negative dialectics for our picture of him to avoid the problematic distortions it has been subjected to in the past. In this way, Adorno sees the potential for change—what might be—arising from the tensions and contradictions—the countertendencies—that exist within a problematic status quo.
Michael Dwyer
- Published in print:
- 2018
- Published Online:
- January 2019
- ISBN:
- 9781786940469
- eISBN:
- 9781786945150
- Item type:
- chapter
- Publisher:
- Liverpool University Press
- DOI:
- 10.5949/liverpool/9781786940469.003.0001
- Subject:
- History, History of Science, Technology, and Medicine
Prior to the mass social acceptance of childhood immunization in the 1940s, diphtheria was one of the most prolific child killers in history. The formation of a leathery membrane in the lower airways ...
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Prior to the mass social acceptance of childhood immunization in the 1940s, diphtheria was one of the most prolific child killers in history. The formation of a leathery membrane in the lower airways induced death by suffocation and earned diphtheria the moniker ‘strangling angel of children’. It showed scant regard for social status and infiltrated Europe’s royal palaces as sinuously as her slums and hovels. For parents and children of nineteenth and early twentieth-century Ireland, diphtheria represented the ‘most dreaded disease of childhood’ however, for their modern-day counterparts’ diphtheria has been relegated to a somewhat obscure disease. Few Irish doctors have seen a case of diphtheria, let alone treated one. In Ireland, diphtheria has been consigned to history, and so too have the horrors and mass fatalities once associated with it. But how was this achieved? Was active immunization received with open arms by public health authorities, the wider medical community, and the general public? This book tackles these questions by undertaking the first historical examination of the issues that underpin the origins of active immunization in Ireland. It explores the driving forces that shaped the national childhood immunization programme, and those that opposed them. In addition, it examines the complex social implications attendant on the introduction of this mass public health intervention.Less
Prior to the mass social acceptance of childhood immunization in the 1940s, diphtheria was one of the most prolific child killers in history. The formation of a leathery membrane in the lower airways induced death by suffocation and earned diphtheria the moniker ‘strangling angel of children’. It showed scant regard for social status and infiltrated Europe’s royal palaces as sinuously as her slums and hovels. For parents and children of nineteenth and early twentieth-century Ireland, diphtheria represented the ‘most dreaded disease of childhood’ however, for their modern-day counterparts’ diphtheria has been relegated to a somewhat obscure disease. Few Irish doctors have seen a case of diphtheria, let alone treated one. In Ireland, diphtheria has been consigned to history, and so too have the horrors and mass fatalities once associated with it. But how was this achieved? Was active immunization received with open arms by public health authorities, the wider medical community, and the general public? This book tackles these questions by undertaking the first historical examination of the issues that underpin the origins of active immunization in Ireland. It explores the driving forces that shaped the national childhood immunization programme, and those that opposed them. In addition, it examines the complex social implications attendant on the introduction of this mass public health intervention.
Constantine Michalopoulos
- Published in print:
- 2020
- Published Online:
- May 2020
- ISBN:
- 9780198850175
- eISBN:
- 9780191884627
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/oso/9780198850175.003.0007
- Subject:
- Economics and Finance, Development, Growth, and Environmental, Economic History
The end of the twentieth century and the beginning of the next millennium was characterized by an extraordinary burst of international cooperation on development. At the core of this cooperation was ...
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The end of the twentieth century and the beginning of the next millennium was characterized by an extraordinary burst of international cooperation on development. At the core of this cooperation was the UN Millennium Summit in September 2000 and the related agreement to achieve the Millennium Development Goals (MDGs). The U4 played a role both in the run-up to the MDG agreement and in linking the achievement of the MDG objective of ending poverty to collaborative efforts between donor and recipient, with partners in the driver’s seat setting their own priorities. This chapter starts with a discussion of the agreement to establish the MDGs at the UN and its implications for development. Then it turns to the perennial question of how much aid developed countries should commit to provide to developing countries, and what donors and recipients must do to make aid more effective, two central issues of the Monterrey Conference on Finance for Development in 2002. The last part discusses the special U4 and international community efforts to achieve universal primary education and to battle HIV/AIDS, malaria and other diseases.Less
The end of the twentieth century and the beginning of the next millennium was characterized by an extraordinary burst of international cooperation on development. At the core of this cooperation was the UN Millennium Summit in September 2000 and the related agreement to achieve the Millennium Development Goals (MDGs). The U4 played a role both in the run-up to the MDG agreement and in linking the achievement of the MDG objective of ending poverty to collaborative efforts between donor and recipient, with partners in the driver’s seat setting their own priorities. This chapter starts with a discussion of the agreement to establish the MDGs at the UN and its implications for development. Then it turns to the perennial question of how much aid developed countries should commit to provide to developing countries, and what donors and recipients must do to make aid more effective, two central issues of the Monterrey Conference on Finance for Development in 2002. The last part discusses the special U4 and international community efforts to achieve universal primary education and to battle HIV/AIDS, malaria and other diseases.
Anthony Rimmington
- Published in print:
- 2018
- Published Online:
- January 2019
- ISBN:
- 9780190928858
- eISBN:
- 9780190943141
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/oso/9780190928858.003.0012
- Subject:
- History, European Modern History
A number of long-range research programs were initiated by the Red Army’s biological warfare facilities which would bring about the development and application of a range of civil and defense ...
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A number of long-range research programs were initiated by the Red Army’s biological warfare facilities which would bring about the development and application of a range of civil and defense vaccines during the Second World War. As a result, 8.5 million Soviet troops were vaccinated against plague, 90,000 against anthrax and an unknown number against tularemia. In addition, botulinum toxoids and a vaccine against brucellosis were developed. Although the Red Army’s BW institutes made some useful contribution to the development of antibiotics production, it was UK and US scientists who made critical contributions of technology. The same BW facilities also launched a program for the manufacture of bacteriophage preparations which drew heavily on technology developed in Tbilisi.Less
A number of long-range research programs were initiated by the Red Army’s biological warfare facilities which would bring about the development and application of a range of civil and defense vaccines during the Second World War. As a result, 8.5 million Soviet troops were vaccinated against plague, 90,000 against anthrax and an unknown number against tularemia. In addition, botulinum toxoids and a vaccine against brucellosis were developed. Although the Red Army’s BW institutes made some useful contribution to the development of antibiotics production, it was UK and US scientists who made critical contributions of technology. The same BW facilities also launched a program for the manufacture of bacteriophage preparations which drew heavily on technology developed in Tbilisi.