Simon I.R. Noble and Miriam J. Johnson
- Published in print:
- 2008
- Published Online:
- November 2011
- ISBN:
- 9780199232048
- eISBN:
- 9780191730337
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199232048.003.0001
- Subject:
- Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology
This chapter examines the challenge for and the changing role of palliative care, particularly with respect to venous thromboembolism (VTE). There are several factors that have driven the expansion ...
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This chapter examines the challenge for and the changing role of palliative care, particularly with respect to venous thromboembolism (VTE). There are several factors that have driven the expansion of palliative care beyond just the provision of terminal care for cancer patients. These include the advances in the management of metastatic diseases which means that patients with incurable diseases may live longer and receive palliative therapies for several years. This chapter suggests that the challenge for palliative care in VTE is to ensure that patients receive appropriate management that maximizes their quality of life and is in accordance with their wishes.Less
This chapter examines the challenge for and the changing role of palliative care, particularly with respect to venous thromboembolism (VTE). There are several factors that have driven the expansion of palliative care beyond just the provision of terminal care for cancer patients. These include the advances in the management of metastatic diseases which means that patients with incurable diseases may live longer and receive palliative therapies for several years. This chapter suggests that the challenge for palliative care in VTE is to ensure that patients receive appropriate management that maximizes their quality of life and is in accordance with their wishes.
Aneel A. Ashrani and John A. Heit
- Published in print:
- 2008
- Published Online:
- November 2011
- ISBN:
- 9780199232048
- eISBN:
- 9780191730337
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199232048.003.0002
- Subject:
- Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology
This chapter looks at the epidemiology or health-event patterns associated with venous thromboembolism (VTE). It explains that VTE, comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), ...
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This chapter looks at the epidemiology or health-event patterns associated with venous thromboembolism (VTE). It explains that VTE, comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a multifactorial disease, involving interactions between environmental exposures and genetic predispositions. It investigates the disease burden or incidence, outcomes, and risk factors of VTE in the community, the elderly population, and in individuals with advanced diseases.Less
This chapter looks at the epidemiology or health-event patterns associated with venous thromboembolism (VTE). It explains that VTE, comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a multifactorial disease, involving interactions between environmental exposures and genetic predispositions. It investigates the disease burden or incidence, outcomes, and risk factors of VTE in the community, the elderly population, and in individuals with advanced diseases.
Sarah J. Lewis
- Published in print:
- 2008
- Published Online:
- November 2011
- ISBN:
- 9780199232048
- eISBN:
- 9780191730337
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199232048.003.0003
- Subject:
- Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology
This chapter examines the pathogenesis of venous thromboembolism (VTE) in patients with cancer. It explains that patients with cancer are more likely to develop VTE than those without. This is ...
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This chapter examines the pathogenesis of venous thromboembolism (VTE) in patients with cancer. It explains that patients with cancer are more likely to develop VTE than those without. This is because the coagulation cascade is activated by factors related both directly and indirectly to the tumour, and all parts of Virchow's triad may be involved with the development of thrombosis. Despite the progress in thrombosis research, many questions remain unanswered including the role of primary thromboprophylaxis and the possibility of adjuvant anticoagulation as an anticancer therapy.Less
This chapter examines the pathogenesis of venous thromboembolism (VTE) in patients with cancer. It explains that patients with cancer are more likely to develop VTE than those without. This is because the coagulation cascade is activated by factors related both directly and indirectly to the tumour, and all parts of Virchow's triad may be involved with the development of thrombosis. Despite the progress in thrombosis research, many questions remain unanswered including the role of primary thromboprophylaxis and the possibility of adjuvant anticoagulation as an anticancer therapy.
Robert Weinkove and Beverley J. Hunt
- Published in print:
- 2008
- Published Online:
- November 2011
- ISBN:
- 9780199232048
- eISBN:
- 9780191730337
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199232048.003.0005
- Subject:
- Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology
This chapter aims to review the pharmacology and use of both the established and the newer anticoagulants used in venous thromboembolism (VTE). These include unfractionated heparin, low molecular ...
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This chapter aims to review the pharmacology and use of both the established and the newer anticoagulants used in venous thromboembolism (VTE). These include unfractionated heparin, low molecular weight heparins (LMWH), danaparoid, coumarins, idraparinux, and hirudin. This chapter discusses the history, composition, mechanism of action, dosage, monitoring, reversal, indications and contraindications, and adverse effects of these anticoagulants.Less
This chapter aims to review the pharmacology and use of both the established and the newer anticoagulants used in venous thromboembolism (VTE). These include unfractionated heparin, low molecular weight heparins (LMWH), danaparoid, coumarins, idraparinux, and hirudin. This chapter discusses the history, composition, mechanism of action, dosage, monitoring, reversal, indications and contraindications, and adverse effects of these anticoagulants.
Agnes Y.Y. Lee
- Published in print:
- 2008
- Published Online:
- November 2011
- ISBN:
- 9780199232048
- eISBN:
- 9780191730337
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199232048.003.0006
- Subject:
- Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology
This chapter discusses the treatment and secondary prevention measures for venous thromboembolism (VTE) in advanced cancer. It evaluates the general approach to treating cancer patients with acute ...
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This chapter discusses the treatment and secondary prevention measures for venous thromboembolism (VTE) in advanced cancer. It evaluates the general approach to treating cancer patients with acute deep vein thrombosis (DVT) or pulmonary embolism and discusses some controversial areas of management. It provides several reports to illustrate management options and considerations that are unique to patients with advanced disease.Less
This chapter discusses the treatment and secondary prevention measures for venous thromboembolism (VTE) in advanced cancer. It evaluates the general approach to treating cancer patients with acute deep vein thrombosis (DVT) or pulmonary embolism and discusses some controversial areas of management. It provides several reports to illustrate management options and considerations that are unique to patients with advanced disease.
Simon I.R. Noble
- Published in print:
- 2008
- Published Online:
- November 2011
- ISBN:
- 9780199232048
- eISBN:
- 9780191730337
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199232048.003.0007
- Subject:
- Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology
This chapter reviews the current published evidence available that may guide the clinician in the appropriate use of primary thromboprophylaxis and in the application of this evidence in the care of ...
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This chapter reviews the current published evidence available that may guide the clinician in the appropriate use of primary thromboprophylaxis and in the application of this evidence in the care of advanced cancer patients. It provides recommendations for the prevention of venous thromboembolism (VTE) in the real world palliative care setting and discusses some relevant clinical cases. It suggests that thromboprophylaxis is inappropriate in the terminal phases since symptoms attributable to VTE can be managed with end-of-life drugs.Less
This chapter reviews the current published evidence available that may guide the clinician in the appropriate use of primary thromboprophylaxis and in the application of this evidence in the care of advanced cancer patients. It provides recommendations for the prevention of venous thromboembolism (VTE) in the real world palliative care setting and discusses some relevant clinical cases. It suggests that thromboprophylaxis is inappropriate in the terminal phases since symptoms attributable to VTE can be managed with end-of-life drugs.
Dawn Dowding and Miriam J. Johnson
- Published in print:
- 2008
- Published Online:
- November 2011
- ISBN:
- 9780199232048
- eISBN:
- 9780191730337
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199232048.003.0008
- Subject:
- Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology
This chapter examines the specific issues connected to clinical decision-making concerning whether or not to treat a venous thromboembolism (VTE) patient with advanced cancer in the palliative care ...
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This chapter examines the specific issues connected to clinical decision-making concerning whether or not to treat a venous thromboembolism (VTE) patient with advanced cancer in the palliative care setting. It discusses how strategies from the broader literature on decision-making in healthcare could be applied to the palliative care setting. It recommends the use of a tool called clinical decision analysis which can integrate both research evidence and measures of patient preferences in order to suggest what the optimum option may be for that patient.Less
This chapter examines the specific issues connected to clinical decision-making concerning whether or not to treat a venous thromboembolism (VTE) patient with advanced cancer in the palliative care setting. It discusses how strategies from the broader literature on decision-making in healthcare could be applied to the palliative care setting. It recommends the use of a tool called clinical decision analysis which can integrate both research evidence and measures of patient preferences in order to suggest what the optimum option may be for that patient.
Anna Spathis and Sara Booth
- Published in print:
- 2008
- Published Online:
- November 2011
- ISBN:
- 9780199232048
- eISBN:
- 9780191730337
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199232048.003.0009
- Subject:
- Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology
This chapter provides an overview of existing evidence in relation to the management of venous thromboembolism (VTE) in non-malignant diseases or noncancer diagnoses. Diagnosis of VTE in ...
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This chapter provides an overview of existing evidence in relation to the management of venous thromboembolism (VTE) in non-malignant diseases or noncancer diagnoses. Diagnosis of VTE in non-malignant disease can be challenging as the clinical features of the condition, such as chronic obstructive pulmonary disease (COPD) or stroke with concurrent pneumonia, may mimic or obscure symptoms of pulmonary embolism. Many non-malignant conditions including heart failure and renal failure are associated with an increased risk of bleeding with anticoagulation.Less
This chapter provides an overview of existing evidence in relation to the management of venous thromboembolism (VTE) in non-malignant diseases or noncancer diagnoses. Diagnosis of VTE in non-malignant disease can be challenging as the clinical features of the condition, such as chronic obstructive pulmonary disease (COPD) or stroke with concurrent pneumonia, may mimic or obscure symptoms of pulmonary embolism. Many non-malignant conditions including heart failure and renal failure are associated with an increased risk of bleeding with anticoagulation.
