Sara Shostak
- Published in print:
- 2013
- Published Online:
- January 2017
- ISBN:
- 9780520275171
- eISBN:
- 9780520955240
- Item type:
- chapter
- Publisher:
- University of California Press
- DOI:
- 10.1525/california/9780520275171.003.0006
- Subject:
- Public Health and Epidemiology, Public Health
Chapter 5 examines scientists’ efforts to facilitate the diffusion of a specific molecular practice-toxicogenomics-from the laboratories of the National Cancer Institute (NCI) and the NIEHS to the ...
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Chapter 5 examines scientists’ efforts to facilitate the diffusion of a specific molecular practice-toxicogenomics-from the laboratories of the National Cancer Institute (NCI) and the NIEHS to the regulatory review protocols of the EPA. It demonstrates that the efforts of scientists, bioethicists, lawyers, and policymakers to anticipate and address the requirements of environmental risk assessment at the EPA have been an intrinsic part of the development of the science itself. It also describes the emergence of new initiatives, such as Tox21, a collaboration between the National Institutes of Health and the Environmental Protection AgencyLess
Chapter 5 examines scientists’ efforts to facilitate the diffusion of a specific molecular practice-toxicogenomics-from the laboratories of the National Cancer Institute (NCI) and the NIEHS to the regulatory review protocols of the EPA. It demonstrates that the efforts of scientists, bioethicists, lawyers, and policymakers to anticipate and address the requirements of environmental risk assessment at the EPA have been an intrinsic part of the development of the science itself. It also describes the emergence of new initiatives, such as Tox21, a collaboration between the National Institutes of Health and the Environmental Protection Agency
Heather B. Patisaul and Scott M. Belcher
- Published in print:
- 2017
- Published Online:
- May 2017
- ISBN:
- 9780199935734
- eISBN:
- 9780190678524
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199935734.003.0008
- Subject:
- Psychology, Behavioural Neuroendocrinology
This chapter focuses on the contemporary approaches of research being used to understand the actions of EDCs and emerging high-throughput screening approaches to examine new and existing chemicals ...
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This chapter focuses on the contemporary approaches of research being used to understand the actions of EDCs and emerging high-throughput screening approaches to examine new and existing chemicals for endocrine-disrupting activities. Concepts arising from the 2007 NRC report “Toxicity Testing in the 21st Century: A Vision and a Strategy” are delineated and the ongoing development of predictive computational toxicology approaches are addressed. The screening strategies being developed under the Tox21 and Toxicity Forecaster (ToxCast) programs are described, with a review of advantages, challenges, and progress to date. There is a brief overview of the EPA’s Interactive Chemical Safety for Sustainability (iCSS) Dashboard as a portal for accessing the ToxCast data through ToxCastDB, and the EPA’s Aggregated Computational Toxicology data warehouse (ACToR), which contains all publicly available EPA chemical toxicity data. Additional challenges related to the inability of current screening approaches to address complex physiology involved in neuroendocrine disruption are addressed.Less
This chapter focuses on the contemporary approaches of research being used to understand the actions of EDCs and emerging high-throughput screening approaches to examine new and existing chemicals for endocrine-disrupting activities. Concepts arising from the 2007 NRC report “Toxicity Testing in the 21st Century: A Vision and a Strategy” are delineated and the ongoing development of predictive computational toxicology approaches are addressed. The screening strategies being developed under the Tox21 and Toxicity Forecaster (ToxCast) programs are described, with a review of advantages, challenges, and progress to date. There is a brief overview of the EPA’s Interactive Chemical Safety for Sustainability (iCSS) Dashboard as a portal for accessing the ToxCast data through ToxCastDB, and the EPA’s Aggregated Computational Toxicology data warehouse (ACToR), which contains all publicly available EPA chemical toxicity data. Additional challenges related to the inability of current screening approaches to address complex physiology involved in neuroendocrine disruption are addressed.
