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Evolutionary genetics and the emergence of SARS Coronavirus

Edward C. Holmes and Andrew Rambaut

in SARS: A case study in emerging infections

Published in print:
2005
Published Online:
September 2007
ISBN:
9780198568193
eISBN:
9780191718175
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198568193.003.0003
Subject:
Biology, Disease Ecology / Epidemiology

RNA viruses experience rates of mutation that are some six orders of magnitude higher than those seen in eukaryotes, which undoubtedly gives them great adaptability. Paradoxically, these mutation ... More


GETTING LUCKY WITH A FAULTY GENE: Escape from Simple Retroviruses

Jaap Goudsmit

in Viral Fitness: The Next SARS and West Nile in the Making

Published in print:
2004
Published Online:
September 2007
ISBN:
9780195130348
eISBN:
9780199790166
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195130348.003.0007
Subject:
Biology, Microbiology

This chapter discusses simple retroviruses. Simple retroviruses belong to the same RNA virus family as the AIDS virus, but unlike HIV, they do not attack humans. Simple retroviruses have only three ... More


Landscapes

Ricard Solé and Santiago F. Elena

in Viruses as Complex Adaptive Systems

Published in print:
2018
Published Online:
May 2019
ISBN:
9780691158846
eISBN:
9780691185118
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691158846.003.0003
Subject:
Biology, Evolutionary Biology / Genetics

This chapter begins by discussing fitness landscape, an idea first introduced by evolutionary geneticist Sewall Wright and later extended by several other authors. The fitness landscape is defined in ... More


Emergence of new infectious diseases

Mark Woolhouse and Rustom Antia

in Evolution in Health and Disease

Published in print:
2007
Published Online:
April 2010
ISBN:
9780199207466
eISBN:
9780191728167
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199207466.003.0016
Subject:
Biology, Evolutionary Biology / Genetics

This chapter reviews the evolution and ecology of emerging diseases. Human infectious diseases are caused by more than 1400 pathogen species with considerable diversity in lifestyles. Almost all ... More


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