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Neuroprotective Strategies in Parkinson’s Disease

C. Warren Olanow

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0035
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter focuses on neuroprotective therapies for Parkinson's disease (PD). PD patients inevitably develop disability despite currently available medical and surgical therapies. Accordingly, a ... More


Movement Disorders

Lorene M. Nelson, Caroline M. Tanner, Stephen K. Van Den Eeden, and Valerie M. McGuire

in Neuroepidemiology: From principles to practice

Published in print:
2004
Published Online:
September 2009
ISBN:
9780195133790
eISBN:
9780199863730
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195133790.003.06
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter covers five movement disorders: Parkinson's disease, dystonia, tic disorders, Huntington's disease, and essential tremor. These disorders demonstrate many of the most common challenges ... More


Structural Abnormalities in Parkinson’s Disease: MRI and Related Methods

Kathrin Reetz and Ferdinand Binkofski

in Imaging in Parkinson’s Disease

Published in print:
2011
Published Online:
September 2011
ISBN:
9780195393484
eISBN:
9780199914494
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393484.003.0027
Subject:
Neuroscience, Disorders of the Nervous System, Techniques

The traditional role of MRI in parkinsonism is to exclude secondary causes of symptoms. Recent advances in MR methodology, including voxel-based morphometry, diffusion imaging, and inversion recovery ... More


Exploring the Myths about Parkinson’s Disease

Yves Agid and Andreas Hartmann

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0029
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter addresses nine myths about Parkinson's disease (PD). Among these are the myths that PD is a movement disorder characterized by the classic triad of akinesia, rigidity, and tremor; that ... More


Progression of Parkinson’s Disease Revealed by Imaging Studies

David J. Brooks

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0031
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter discusses imaging studies of Parkinson's disease (PD). Imaging dopaminergic function with positron emission tomography (PET) and single photon computed emission tomography (SPECT) or ... More


Transplantation of Dopamine Neurons: Extent and Mechanisms of Functional Recovery in Rodent Models of Parkinson's Disease

Stephen B. Dunnett and Anders Björklund

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0032
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter reviews the transplantation of dopamine (DA) neurons as a powerful model for understanding the basic neurobiology and methods for achieving viable cell transplantation in the brain. ... More


Clinical Experiences with Dopamine Neuron Replacement in Parkinson’s Disease: What Is the Future?

Olle Lindvall

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0033
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Cell therapy research in Parkinson's disease (PD) seeks to develop this approach into a clinically competitive treatment. It should be emphasized, though, that during the more than 20 years since the ... More


Bioethics and the Brain

Walter Glannon

Published in print:
2006
Published Online:
January 2007
ISBN:
9780195307788
eISBN:
9780199867431
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195307788.001.0001
Subject:
Philosophy, Moral Philosophy

Our ability to map and intervene in the structure of the human brain is proceeding at a very quick rate. Advances in psychiatry, neurology, and neurosurgery have given us fresh insights into the ... More


Cortical Oscillations in Health and Disease

Roger Traub, MD and Miles Whittington, PhD

Published in print:
2010
Published Online:
May 2010
ISBN:
9780195342796
eISBN:
9780199776276
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195342796.001.0001
Subject:
Neuroscience, Molecular and Cellular Systems, Development

This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions ... More


Imaging in Parkinson’s Disease

David Eidelberg

Published in print:
2011
Published Online:
September 2011
ISBN:
9780195393484
eISBN:
9780199914494
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393484.001.0001
Subject:
Neuroscience, Disorders of the Nervous System, Techniques

This volume provides up-to-date information concerning new applications of brain imaging to the study of Parkinson’s disease (PD). The chapters, written by experts in this field, focus on the various ... More


Diseases of the nervous system

Fabrizio Benedetti

in Placebo Effects: Understanding the mechanisms in health and disease

Published in print:
2008
Published Online:
September 2009
ISBN:
9780199559121
eISBN:
9780191724022
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199559121.003.0004
Subject:
Neuroscience, Molecular and Cellular Systems

Besides pain, Parkinson's disease represents an excellent model to study the neurobiological mechanisms of the placebo effect. The placebo effect in Parkinson's disease is mediated by dopamine ... More


Pathophysiology of L-DOPA-Induced Dyskinesia in Parkinson's Disease

M. Angela Cenci

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0030
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter begins with a discussion of motor complications of L-DOPA pharmacotherapy. It then discusses animal models of treatment-induced motor complications and the multilayered pathophysiology ... More


Novel Gene-Based Therapeutics Targeting the Dopaminergic System in Parkinson’s Disease

Deniz Kirik, Tomas Björklund, Shilpa Ramaswamy, and Jeffrey H. Kordower

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0034
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Novel therapeutic intervention based on gene therapy has moved the field of Parkinson's disease (PD) research forward during the last decade. The process of supplementing cells with genes that ... More


Cortical Lewy body disease: dementia with Lewy bodies and Parkinson's disease with dementia

John E. Duda and Ian G. McKeith

in Cognitive Neurology: A clinical textbook

Published in print:
2008
Published Online:
March 2012
ISBN:
9780198569275
eISBN:
9780191724213
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569275.003.0015
Subject:
Neuroscience, Techniques

One of the most hotly debated topics in the field of neurodegenerative disease is the relationship between what has recently been described as dementia with Lewy bodies (DLB) and the condition of ... More


Sex Differences in Parkinson’s Disease

David G. Standaert and Ippolita Cantuti-Castelvetri

in Sex Differences in the Brain: From Genes to Behavior

Published in print:
2007
Published Online:
January 2010
ISBN:
9780195311587
eISBN:
9780199865048
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195311587.003.0023
Subject:
Neuroscience, Molecular and Cellular Systems

Parkinson's disease (PD) is a slow progressing neurodegenerative disease affecting up to 3% of the population over the age of 65 years, amounting to more than 500,000 individuals in the United ... More


Cerebral Glucose Metabolism and Blood Flow in Parkinson’s Disease

Yilong Ma, Shichun Peng, Vijay Dhawan, and David Eidelberg

in Imaging in Parkinson’s Disease

Published in print:
2011
Published Online:
September 2011
ISBN:
9780195393484
eISBN:
9780199914494
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393484.003.0021
Subject:
Neuroscience, Disorders of the Nervous System, Techniques

Functional brain imaging has been widely used to describe regional abnormalities in cerebral blood flow and metabolism in Parkinson’s disease (PD) patients scanned in the rest state with PET, SPECT, ... More


Functional Markers of Cognition in Parkinson’s Disease: 18F-FDG and H2 15O Positron Emission Tomography Studies

Paul J. Mattis and Maren Carbon

in Imaging in Parkinson’s Disease

Published in print:
2011
Published Online:
September 2011
ISBN:
9780195393484
eISBN:
9780199914494
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393484.003.0066
Subject:
Neuroscience, Disorders of the Nervous System, Techniques

Cognitive and behavioral problems are common in patients with Parkinson’s disease (PD), with the prevalence of dementia in patients with PD conservatively estimated to range between 24% and 31%. ... More


Older Adults With Neurological Problems Without Significant Dementia

Gladys GonzáLez-Ramos

in Handbook of Social Work in Health and Aging

Published in print:
2006
Published Online:
April 2010
ISBN:
9780195173727
eISBN:
9780199893218
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195173727.003.0009
Subject:
Social Work, Health and Mental Health

This chapter covers two of the most prevalent neurological disorders, Parkinson's disease (PD) and multiple sclerosis (MS). Although both diseases typically can be quite debilitating and impact a ... More


Functional Imaging Biomarkers for the Assessment of Parkinson’s Disease Progression

Chris C. Tang and David Eidelberg

in Imaging in Parkinson’s Disease

Published in print:
2011
Published Online:
September 2011
ISBN:
9780195393484
eISBN:
9780199914494
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393484.003.0093
Subject:
Neuroscience, Disorders of the Nervous System, Techniques

A reasonable degree of symptom relief can be achieved in most PD patients, particularly at early disease stages. Nonetheless, despite symptomatic treatment, the disease process continues, with the ... More


Dopaminergic Imaging in Parkinson’s Disease: SPECT

Christoph Scherfler and Werner Poewe

in Imaging in Parkinson’s Disease

Published in print:
2011
Published Online:
September 2011
ISBN:
9780195393484
eISBN:
9780199914494
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393484.003.0015
Subject:
Neuroscience, Disorders of the Nervous System, Techniques

The diagnosis of idiopathic Parkinson’s disease (PD) can often be made on clinical grounds with a high degree of accuracy particularly in cases with full expression of the classical motor features of ... More


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