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The human epigenome and cancer

Mukesh Verma

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0028
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Epigenetics, the study of mechanisms that involve mitotically heritable changes in DNA other than changes in nucleotide sequence, represents a new frontier in research, especially in cancer. Most of ... More


Cancer Incidence, Mortality, and Patient Survival in the United States

LYNN A.G. RIES and SUSAN S. DEVESA

in Cancer Epidemiology and Prevention

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195149616
eISBN:
9780199865062
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195149616.003.0009
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter presents current estimates for cancer incidence, mortality, and survival in a large subgroup of the U.S. population based on the results of the Surveillance, Epidemiology, and End ... More


Momentum for Molecular Medicine

Robin Wolfe Scheffler

in A Contagious Cause: The American Hunt for Cancer Viruses and the Rise of Molecular Medicine

Published in print:
2019
Published Online:
January 2020
ISBN:
9780226458892
eISBN:
9780226628400
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226628400.003.0011
Subject:
History, History of Science, Technology, and Medicine

Chapter 10 explains how molecular approaches to cancer survived a period of political and cultural disillusionment in the late 1970s. Environmental and social approaches to the cancer problem ... More


Managing the Future at the Special Virus Leukemia Program

Robin Wolfe Scheffler

in A Contagious Cause: The American Hunt for Cancer Viruses and the Rise of Molecular Medicine

Published in print:
2019
Published Online:
January 2020
ISBN:
9780226458892
eISBN:
9780226628400
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226628400.003.0006
Subject:
History, History of Science, Technology, and Medicine

The changing political circumstances discussed in chapter 4 gave the National Cancer Institute unprecedented resources for biomedical research into cancer. However, this windfall also created ... More


Policymakers and Philanthropists Define the Cancer Problem

Robin Wolfe Scheffler

in A Contagious Cause: The American Hunt for Cancer Viruses and the Rise of Molecular Medicine

Published in print:
2019
Published Online:
January 2020
ISBN:
9780226458892
eISBN:
9780226628400
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226628400.003.0004
Subject:
History, History of Science, Technology, and Medicine

Chapter 3 examines how “the cancer problem” was defined by the participants in the “associative state”—the professional social welfare and professional groups to which the federal government deferred ... More


Why Climate-Change Skeptics Are Wrong

Kristin Shrader-Frechette

in What Will Work: Fighting Climate Change with Renewable Energy, Not Nuclear Power

Published in print:
2011
Published Online:
January 2012
ISBN:
9780199794638
eISBN:
9780199919277
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199794638.003.0001
Subject:
Philosophy, Moral Philosophy

Chapter 1 begins by stressing the severity of climate change (CC) and showing how, contrary to popular belief, atomic energy is not a viable solution to ... More


Targeted Therapy and Clinical Cancer Research

Peter Keating and Alberto Cambrosio

in Cancer on Trial: Oncology as a New Style of Practice

Published in print:
2012
Published Online:
September 2013
ISBN:
9780226428918
eISBN:
9780226428932
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226428932.003.0154
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the major turning points in the clinical trial process and examines the consequences of the oncogene revolution for the conduct of clinical cancer trials. It begins with the ... More


Peripheral Assent

in The Cuban Cure: Reason and Resistance in Global Science

Published in print:
2010
Published Online:
March 2013
ISBN:
9780226709178
eISBN:
9780226709192
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226709192.003.0008
Subject:
History, History of Science, Technology, and Medicine

This chapter examines the growth of the biotechnology sector in Cuba. It explores Cuba's various attempts to define its biotechnology and its efforts to maintain a space for that science amid a ... More


Time to Go After the Feds

Charles F. Wurster

in DDT Wars: Rescuing Our National Bird, Preventing Cancer, and Creating EDF

Published in print:
2015
Published Online:
November 2020
ISBN:
9780190219413
eISBN:
9780197559512
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190219413.003.0012
Subject:
Environmental Science, Pollution and Threats to the Environment

By the fall of 1969 we knew we had to challenge pesticide regulation by the federal government if we were to ultimately prevail against DDT, but we did not know how to ... More


Factors That Influence Toxicity

Sigmund F. Zakrzewski (ed.)

in Environmental Toxicology

Published in print:
2002
Published Online:
November 2020
ISBN:
9780195148114
eISBN:
9780197565629
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195148114.003.0009
Subject:
Chemistry, Environmental Chemistry

The more species are removed from each other in evolutionary development, the greater is the likelihood of differences in response to toxic agents. One obvious ... More


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