Jump to ContentJump to Main Navigation

You are looking at 1-20 of 37 items

  • Keywords: NMDA receptors x
Clear All Modify Search

View:

The NMDA Receptor

G. L. Collingridge and J. C. Watkins (eds)

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.001.0001
Subject:
Neuroscience, Molecular and Cellular Systems

This book comprises coverage of the NMDA receptor. The NMDA receptor is an important protein in the brain, which is involved in physiological processes such as synaptic transmission and synaptic ... More


Nmda Receptors

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0005
Subject:
Neuroscience, Sensory and Motor Systems

Ionotropic glutamate receptors, including NMDA receptors, mediate most of the excitatory synaptic transmission in the mammalian central nervous system. When NMDA receptors are activated by membrane ... More


Agonists and competitive antagonists: structure-activity and molecular modelling studies

D. E. JANE, H. J. OLVERMAN, and J. C. WATKINS

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0002
Subject:
Neuroscience, Molecular and Cellular Systems

A wealth of information has now been generated, especially from radioligand binding studies, regarding the structural requirements for agonist and antagonist binding to the glutamate recognition site ... More


Excitatory Amino Acid Transmission and Synaptic Plasticity

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0011
Subject:
Neuroscience, Sensory and Motor Systems

Activity-dependent, long-lasting synaptic enhancement induced by neuronal stimulation, known as long-term potentiation (LTP), is not unique to the hippocampus; rather, it seems to be a fundamental ... More


NMDA receptors and their interactions with other excitatory amino acid receptors in synaptic transmission in the mammalian central nervous system

T. E. SALT

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0010
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter seeks to review some of the electrophysiological work which has been carried out using excitatory amino acid antagonists. A selection of studies of brain areas has been chosen for review ... More


Non-competitive antagonists of N-methyl-D-aspartate

DAVID LODGE, MARTYN JONES, and ELIZABETH FLETCHER

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0003
Subject:
Neuroscience, Molecular and Cellular Systems

The ability of d-α-aminoadipate (DAA) and a range of related substances to act as amino acid antagonists has been found to parallel the ability of these substances to displace binding of tritiated ... More


The NMDA receptor concept: origins and development

J. C. WATKINS

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0001
Subject:
Neuroscience, Molecular and Cellular Systems

The progress of research in the excitatory amino acid (EAA) field over the last forty years is well documented. The field had its origin in the discovery by Hayashi (1954) of the convulsive effects ... More


The NMDA receptor in epilepsy

SUZANNE CLARK, STEVEN STASHEFF, DARRELL V. LEWIS, DAVID MARTIN, and WILKIE A. WILSON

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0017
Subject:
Neuroscience, Molecular and Cellular Systems

Few things have generated more excitement in the field of epilepsy than studies suggesting that N-methyl-d-aspartate (NMDA) receptors may play a role in the development and expression of seizures. It ... More


NMDA receptors, neuronal development, and neurodegeneration

JOHN GARTHWAITE

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0018
Subject:
Neuroscience, Molecular and Cellular Systems

In several brain regions, N-methyl-d-aspartate (NMDA) receptors are specially effective during the developmental period, where they appear to play important roles in the formation and stabilization ... More


The NMDA receptor, its channel, and its modulation by glycine

P. ASCHER and J. W. JOHNSON

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0007
Subject:
Neuroscience, Molecular and Cellular Systems

Of the glutamate receptors, the N-methyl-d-aspartate (NMDA) one is certainly the most popular choice of research scientists. This popularity is partly due to the recognition that the receptor plays a ... More


NMDA receptor targeting

Heike Hering and Morgan Sheng

in Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels

Published in print:
2002
Published Online:
March 2012
ISBN:
9780192632241
eISBN:
9780191724763
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192632241.003.0007
Subject:
Neuroscience, Molecular and Cellular Systems

The N-methyl-d-aspartate (NMDA) class of ionotropic glutamate receptor has received special attention because it is critical for many forms of activity-dependent synaptic plasticity, some of which ... More


Trafficking of Glutamate Receptors

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0010
Subject:
Neuroscience, Sensory and Motor Systems

The molecular composition of the excitatory synapses is far from static. Indeed, changes in the localization and density of excitatory amino acid receptors are now recognized as an essential ... More


NMDA receptor agonists and competitive antagonists

MARK L. MAYER, MORRIS BENVENISTE, and DORIS K. PATNEAU

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0004
Subject:
Neuroscience, Molecular and Cellular Systems

NMDA receptors have a rich and diverse pharmacology reflecting the presence of multiple ligand binding sites at which agonists, antagonists, and modulators interact in an allosteric manner. This ... More


The role of NMDA receptors in synaptic integration and the organization of motor patterns

SIMON ALFORD and LENNART BRODIN

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0012
Subject:
Neuroscience, Molecular and Cellular Systems

The ubiquity of the N-methyl-d-aspartate (NMDA) receptor throughout much of the vertebrate central nervous system (CNS), coupled with its unique properties, result not only in its functional ... More


Molecular Organization of Glutamate Receptors in the Postsynaptic Density

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0009
Subject:
Neuroscience, Sensory and Motor Systems

A significant advance in the field of excitatory amino acid (EAA) transmission has been the great progress made toward elucidation of the molecular composition and function of the postsynaptic ... More


The role of NMDA receptors in learning and memory

R. G. M. MORRIS and M. DAVIS

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0015
Subject:
Neuroscience, Molecular and Cellular Systems

An early finding was that AP5 appeared to impair spatial learning, a type of learning known to be dependent upon the integrity of the very structure, the hippocampus, in which LTP was first ... More


Molecular Mechanisms of Memory Consolidation

Kevin M. Hellman and Ted Abel

in Sleep and Brain Plasticity

Published in print:
2003
Published Online:
September 2009
ISBN:
9780198574002
eISBN:
9780191724145
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198574002.003.0016
Subject:
Neuroscience, Behavioral Neuroscience

This chapter describes how neuromodulators and electrophysiological phenomena in the hippocampus during NREM and REM sleep affect intracellular signaling pathways that are known to mediate memory ... More


The time course of NMDA receptor-mediated synaptic currents

ROBIN A. J. LESTER, JOHN D. CLEMENTS, GANG TONG, GARY L. WESTBROOK, and CRAIG E. JAHR

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0008
Subject:
Neuroscience, Molecular and Cellular Systems

The slowly rising, long-lasting time course of the NMDA receptor-mediated excitatory post-synaptic current (EPSC) is unusual for a response mediated by a directly gated ion channel. Although the EPSC ... More


NMDA receptors and long-term potentiation in the hippocampus

ZAFAR I. BASHIR, NICOLA BERRETTA, ZUNER A. BORTOLOTTO, KATH CLARK, CERI H. DAVIES, BRUNO G. FRENGUELLI, JENNI HARVEY, BRIGITTE POTIER, and GRAHAM L. COLLINGRIDGE

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0013
Subject:
Neuroscience, Molecular and Cellular Systems

N-methyl-d-aspartate (NMDA) receptors have been shown to have two important physiological roles in the vertebrate central nervous system; they are mediators of synaptic ... More


Functional plasticity at dendritic synapses

Zachary F. Mainen and Larry F. Abbott

in Dendrites

Published in print:
2007
Published Online:
March 2012
ISBN:
9780198566564
eISBN:
9780191724206
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198566564.003.0018
Subject:
Neuroscience, Molecular and Cellular Systems

Most synapses are made onto dendrites, and most excitatory connections are made onto dendritic spines. Synaptic plasticity is thus an intrinsically dendritic phenomenon, but the functional ... More


View: