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Explaining the Brain

Carl F. Craver

Published in print:
2007
Published Online:
January 2009
ISBN:
9780199299317
eISBN:
9780191715075
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299317.001.0001
Subject:
Philosophy, Philosophy of Mind, Philosophy of Science

What distinguishes good explanations in neuroscience from bad? This book constructs and defends standards for evaluating neuroscientific explanations that are grounded in a systematic view of what ... More


Terje Lømo

Larry R. Squire

in The History of Neuroscience in Autobiography: Volume 7

Published in print:
2011
Published Online:
January 2012
ISBN:
9780195396133
eISBN:
9780199918409
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195396133.003.0009
Subject:
Neuroscience, History of Neuroscience

Terje Lømo discovered long term potentiation (LTP) and with Tim Bliss did the first systematic study of LTP. Lømo discovered that evoked muscle impulse activity per se controlled the properties of ... More


Cellular Mechanisms of Memory: Complex Circuits

Howard Eichenbaum

in The Cognitive Neuroscience of Memory: An Introduction

Published in print:
2002
Published Online:
May 2009
ISBN:
9780195141740
eISBN:
9780199865741
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141740.003.0003
Subject:
Neuroscience, Behavioral Neuroscience, Molecular and Cellular Systems

This chapter reviews recent progress toward a full characterization of one particular form of synaptic plasticity observed in the mammalian brain called long-term potentiation (LTP). LTP can be ... More


NMDA receptors and long-term potentiation in the hippocampus

ZAFAR I. BASHIR, NICOLA BERRETTA, ZUNER A. BORTOLOTTO, KATH CLARK, CERI H. DAVIES, BRUNO G. FRENGUELLI, JENNI HARVEY, BRIGITTE POTIER, and GRAHAM L. COLLINGRIDGE

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0013
Subject:
Neuroscience, Molecular and Cellular Systems

N-methyl-d-aspartate (NMDA) receptors have been shown to have two important physiological roles in the vertebrate central nervous system; they are mediators of synaptic ... More


The role of NMDA receptors in learning and memory

R. G. M. MORRIS and M. DAVIS

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0015
Subject:
Neuroscience, Molecular and Cellular Systems

An early finding was that AP5 appeared to impair spatial learning, a type of learning known to be dependent upon the integrity of the very structure, the hippocampus, in which LTP was first ... More


NMDA receptor targeting

Heike Hering and Morgan Sheng

in Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels

Published in print:
2002
Published Online:
March 2012
ISBN:
9780192632241
eISBN:
9780191724763
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192632241.003.0007
Subject:
Neuroscience, Molecular and Cellular Systems

The N-methyl-d-aspartate (NMDA) class of ionotropic glutamate receptor has received special attention because it is critical for many forms of activity-dependent synaptic plasticity, some of which ... More


To consolidate or not to consolidate: what are the questions?

Yadin Dudai and Richard G.M. Morris

in Brain, Perception, Memory: Advances in Cognitive Neuroscience

Published in print:
2000
Published Online:
March 2012
ISBN:
9780198524823
eISBN:
9780191689246
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198524823.003.0011
Subject:
Psychology, Cognitive Psychology

This chapter provides a critical review of the term consolidation, which refers to the processes occurring at the level of the neuron and the synapse during and after memory formation or its neural ... More


Genetic strategies for the study of hippocampal-based memory storage

Danny G. Winder and Eric R. Kandel

in Brain, Perception, Memory: Advances in Cognitive Neuroscience

Published in print:
2000
Published Online:
March 2012
ISBN:
9780198524823
eISBN:
9780191689246
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198524823.003.0012
Subject:
Psychology, Cognitive Psychology

This chapter is a review of recent genetic approaches to the study of learning and memory. With modern genetic techniques, individual genes can be ‘knocked out’ or, alternatively, overexpressed, and ... More


Cannabinoids, Learning, and Memory

Linda A. Parker

in Cannabinoids and the Brain

Published in print:
2017
Published Online:
September 2017
ISBN:
9780262035798
eISBN:
9780262338448
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035798.003.0005
Subject:
Neuroscience, Research and Theory

Global activation of CB1 receptors produces actions on hippocampal neurons, which results in interference with short tem memory and consolidation of memories that are currently being processed. ... More


Memory

Lenn E. Goodman and D. Gregory Caramenico

in Coming to Mind: The Soul and Its Body

Published in print:
2013
Published Online:
January 2014
ISBN:
9780226061061
eISBN:
9780226061238
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226061238.003.0004
Subject:
Philosophy, Philosophy of Mind

Memory has long been pictured as a mark, a stored image, even a scar. But the modern search for the “engram” and the files that might house such bits of experience proves fruitless. Memory is far ... More


Synaptic modification for learning

Edmund T. Rolls

in Cerebral Cortex: Principles of Operation

Published in print:
2016
Published Online:
November 2016
ISBN:
9780198784852
eISBN:
9780191836299
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198784852.003.0009
Subject:
Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience

Long-term potentiation provides a model of synaptic modification, and alters synaptic strength associatively in proportion to the presynaptic firing rate and the post-synaptic activation. This ... More


The importance of Marr’s three levels of analysis for understanding cerebellar function

Paul Dean and John Porrill

in Computational Theories and their Implementation in the Brain: The legacy of David Marr

Published in print:
2016
Published Online:
January 2017
ISBN:
9780198749783
eISBN:
9780191831638
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198749783.003.0004
Subject:
Psychology, Neuropsychology

Marr proposed that complex information processing systems be analysed at three different levels, those of computation, algorithm and implementation. Applying this framework to current research on the ... More


Hippocampal Synaptic Stability and Plasticity: The Role of Hippocampus-Derived Estradiol

Gabriele M. Rune

in Estrogens and Memory: Basic Research and Clinical Implications

Published in print:
2020
Published Online:
February 2020
ISBN:
9780190645908
eISBN:
9780190645922
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190645908.003.0007
Subject:
Psychology, Cognitive Neuroscience

Estradiol synthesis depends on the activity of aromatase, the enzyme that specifically and irreversibly converts testosterone to estradiol in steroidogenesis. Aromatase is expressed and is active in ... More


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