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SNPs, HapMap, and common disease

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0009
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

The extent of single nucleotide polymorphism is reviewed, together with insights gained into the nature of allelic architecture in terms of haplotypes, linkage disequilibrium and recombination. The ... More


Medically relevant variation in the human genome

Diddahally R. Govindaraju and Lynn B Jorde

in Evolution in Health and Disease

Published in print:
2007
Published Online:
April 2010
ISBN:
9780199207466
eISBN:
9780191728167
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199207466.003.0003
Subject:
Biology, Evolutionary Biology / Genetics

Geneticists can now use several million markers to discover genes contributing to human disorders. Some findings confirm classical patterns on the extent and distribution of variation among ... More


Race, Difference, and Genes

Myles W. Jackson

in The Genealogy of a Gene: Patents, HIV/AIDS, and Race

Published in print:
2015
Published Online:
September 2015
ISBN:
9780262028660
eISBN:
9780262327190
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262028660.003.0008
Subject:
History, History of Science, Technology, and Medicine

This chapter situates the CCR5 gene, specifically the Δ‎32 allele, in the contexts of four distinct yet related enterprises- race and genomics, Big Pharma, personalized medicine, and personal ... More


Ancestry and genealogy

Joel T. Dudley

in Exploring Personal Genomics

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199644483
eISBN:
9780191774577
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199644483.003.0005
Subject:
Biology, Evolutionary Biology / Genetics

This chapter explores the genetics of human ancestry. Personal genomics's most intriguing and introspective aspect is the fact that each individual's genome contains the genetic footprints of ... More


Race in the Genomic Age

Michael Yudell and J. Craig Venter

in Race Unmasked: Biology and Race in the Twentieth Century

Published in print:
2014
Published Online:
November 2015
ISBN:
9780231168748
eISBN:
9780231537995
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231168748.003.0012
Subject:
Sociology, Race and Ethnicity

This chapter analyzes the relationship between molecular and evolutionary biology. By the mid-1960s, a new generation of evolutionary biologists—including Richard Lewontin and Jack Hubby—attempted to ... More


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