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The Centers for Disease Control and Prevention has defined a list of human pathogens that are of highest concern for possible use as bioweapons. These agents, most of which had been developed as agents for biological warfare, are described in this chapter. The diseases caused by these agents are now quite rare, and the experience of medical and public health personnel in dealing with them is limited. The course of diseases resulting from various means of exposure are described, along with what is known of the ability of humans to respond to and recover from them. In most cases, adeqaute vaccines do not exist, and only a few effective drugs are available.

This chapter presents an introduction to viruses. Viruses have played a major role not only in evolutionary history but also in recent history. They have shaped human genomes and physiological features, they can be deadly or good, and they can change so fast and affect so many cellular pathways that mounting evidence supports a picture of evolution largely dependent on the driving force provided by these entities. Some viruses' names have become popular in the media because of their terrifying impact through deadly pandemic events. Among them are the human immunodeficiency virus type 1 (HIV-1) and the Ebola virus (EBOV). The remainder of the chapter discusses the expanding viral universe, structural and genetic diversity of viruses, and growth in the importance and understanding of ecological and evolutionary impact of viruses over the last century.

This chapter examines the Ebola virus in detail. Since 1976, with the exception of the 2013–2016 epidemic in West Africa, all outbreaks of Ebola virus infection have occurred in central Africa. The initial 1976 eruption of Ebola in Zaire in central Africa provided lessons for how to control future outbreaks of this disease. Unfortunately, those lessons were not well learned or sufficiently applied to the massive Ebola outbreak that followed in 2013–2016 in western Africa. Ebola virus can spread either through the air or by exposure to contaminated blood of infected humans. The clinical course of Ebola virus infection is that of a severe hemorrhagic fever. An Ebola vaccine was developed and administered to over 40,000 individuals for the 2018–2019 outbreak. However, the vaccine’s effectiveness in the outbreak has not been formally assessed, and critical scientific assessment will be difficult to achieve. Ultimately, Ebola virus remains endemic in Africa. Whether the fruit bat is the only natural reservoir for such viruses, how Ebola is transmitted, and where it lurks are still unresolved.

This chapter considers the ways in which the lines between authoritarianism and democracy and between the past and the present remain blurred in Guinea today. It considers the new role of the private sector in neoliberal cultural initiatives, as illustrated by two concerts held to celebrate the end of the Ebola epidemic in Guinea in 2015. It also notes the continuing endurance of praise singing and musical practices rooted in tradition, collective pride, and cultural memory. It concludes the book with a call to understand authoritarianism from the bottom-up, as a system of power that ordinary people at times invest with meaning and feeling, while also asking how pleasure and aesthetics might create and sustain a different kind of politics in Guinea and a new sense of self-recognition for Guineans in the future.

There are dangers of over-simplification when discussing the development challenges and opportunities facing a continent as vast as Africa at a given point in time! Africa is made up of 54 disparate countries in five regions, and is not a single monolithic whole. The 2014 Ebola crisis in three countries in West Africa once again revealed the tendency of those outside the continent to classify it as a distinct entity. Despite the frequent allusion to a new “Scramble for Africa”, the continent is planning, managing and starting to finance its own destiny, as it attempts to reclaim the twenty-first century. After 2015 Africa anticipates a future that is not just fraught with challenges but also with opportunities. Africa’s vision for the future as it looks beyond the MDGs has been endorsed by Heads of States in the name of Agenda 2063, forming the core element for shaping development conversations for the next 50 years or so.

This chapter highlights three of the recently identified viruses: Lassa fever virus, Ebola virus, and hantavirus. All three are equally lethal infectious agents, but they are members of different viral families. They share the ability to cause hemorrhagic fever. Once infected with any of these viruses, the victim soon suffers profuse breaks in small blood vessels, causing blood to ooze from the skin, mouth, gastrointestinal tract, and rectum. Internally, blood flows into the pleural cavity where the lungs are located, into the pericardial cavity surrounding the heart, into the abdomen, and into organs like the liver, kidney, heart, spleen, and lungs. Eventually, this uncontrolled bleeding causes unconsciousness and death. There is currently no established vaccine to prevent these potential plagues, although several are in various stages of development, and an Ebola vaccine is currently undergoing trial in Africa. The chapter also considers a newly emerging and undefined but serious disease of children, which arose primarily in 2014. Based on clinical observations, the disease is identified by the signs and symptoms of acute flaccid myelitis.

This story of an encounter with a remarkable young man, Prince, during a small incident in an Ebola treatment center provides a window to the lived experience of Ebola caregivers, patients, and survivors. In the Ebola ward, as anywhere else, the living, both the patients and the caregivers, had to go about the business of normal daily life with all its boring routine while they dealt with the fear of crisis and the unexpected. With the high rate of healthcare worker infection, some healthcare workers were not just caregivers but also patients and, for the fortunate, survivors. As Prince’s story reveals, many survivors still grapple with the discomforts of post-Ebola syndrome, social stigma, and the struggle for survival that is life for so many in a resource-poor nation. Prince and others like him continue to conduct themselves with professional integrity and commitment, dignity, and determination.

In chapter 3, John D. Kraemer and J. Mark Siedner map the effect of the Ebola epidemic on health outcomes and systems in Guinea, Liberia, and Sierra Leone. The chapter provides a comprehensive review of existing literature to assess how Ebola caused short- and long-term harm to health that exceeded the direct consequences for those infected. The authors assess the capacity of the already weak healthcare sectors in the three most afflicted countries prior to the outbreak, how redirection of resources to the outbreak compromised critical gains in individual and population health, and what may be expected in the near to long-term as those healthcare systems recover. The chapter identifies opportunities for building stronger, more resilient health systems, focusing on measures that would improve outcomes during both routine and emergency situations.

This chapter considers viral hemorrhagic fever outbreaks in Africa. The best known African viral hemorrhagic fevers are yellow fever, Marburg, and Ebola. Viral hemorrhagic fever outbreaks are promoted by the prevalent mode of medical practice in which etiology is only of interest when a cure fails, and not always even then. Because of the challenges associated with infection control and patient diagnosis, in typical African hemorrhagic fever epidemics the death toll is high and the spread throughout the hospital has already begun before the cause of the outbreak is known or even suspected. As Africans move deeper into forests, and improved travel networks allow individuals to move from the heart of the forest to a city with international connections in just a few hours, contact with wildlife and the risk of contracting and spreading Lassa, Ebola, Marburg, and as yet unknown zoonotic infections will continue to rise. It is essential to focus diagnostic support and research in countries where the diseases occur in nature.

This introductory chapter provides an overview of how viruses have caused geographic, economic, and religious changes. Smallpox alone, in the twentieth century, killed an estimated 300 million individuals, about threefold as many persons as all the wars of that century. In the sixteenth and seventeenth centuries, smallpox killed emperors of Japan and Burma as well as kings and queens of Europe, thereby unseating dynasties, altering control of countries, and disrupting alliances. In addition to propelling the establishment of Christianity in Mexico and Latin America, viruses played a role in enlarging the African slave trade throughout the Americas. In contrast to viruses such as smallpox and measles which are now harnessed by the innovations of healthcare, new viral plagues of fearful proportions have appeared. These include HIV/AIDS, sudden acute respiratory syndrome, Ebola, Zika, and bird flu. This book looks at the history of viruses and virology, which is also the history of the men and women who have worked to combat these diseases.

On May 26, 2014, it was acknowledged that the Ebola virus disease (EVD) epidemic had swept over to Sierra Leone, although several indices imply that EVD infections were more likely to be present much earlier. This chapter was written by one of the first international doctors to answer this first call for aid in May. He describes the situation on the ground, including the challenges of providing medical care for patients suffering from EVD in Sierra Leone’s Kailahun district. He also discusses difficulties in epidemiological surveillance and laboratory diagnostics. He compares this early period of the epidemic to his experience nine months later in Guinea, when a multitude of governmental and nongovernmental actors were present, facilitating and complicating things at the same time.

In early February 2015, the author prepared to leave for her second Ebola mission, this time at an Ebola treatment center in Conakry, the capital of Guinea. During the two-month mission she discovered that the Ebola epidemic created havoc not only by leaving sickness and death in its wake, but also by its perversity. When it seemed to be in decline, new flare-ups would spring up to extend its life. The author recalls a storm of anger and sadness from one bereaved family in a particular violent episode. This made the absurd cruelty of Ebola even more apparent for her.

This chapter discusses the strategic value of landpower in Humanitarian Assistance and Disaster Relief (HA/DR) operations. When disasters occur that are significant enough to derail/delay political agendas, the US government depends on landpower's unique capabilities to support the lead federal agency, the US Agency for International Development. The authors use three disaster relief operations case studies (the 2010 earthquake in Haiti, the 2014 Ebola outbreak in Liberia, and the 2013 Super Typhoon Haiyan in the Philippines) to illuminate the Army's core roles in HA/DR success. Lastly, the chapter discusses the secondary benefits of successful HA/DR operations like enhancing interoperability among joint, interagency, and multinational partners, assuring partners and allies, and reinforcing the strategic narrative of US power.

The 2015 Ebola epidemic, as well as the global migration crisis, bring to light the connection many people make between loathsome disease and strangers. Myths about newcomers and disease have long informed both immigration policy and health policy. This book focuses on the latter and reviews basic demographics about migrants and their health, dispelling the myths that have thus far informed health policy. The book argues that health should be understood as a global public good and that understanding it as such has important moral and practical implications that ought to be taken into account as health policy is developed. This introduction provides a chapter-by-chapter outline of the book.

Humans have long blamed immigrants and outsiders for epidemics. This perceived association between newcomers and disease has led many nations to impose health-related immigration controls that screen newcomers for disease and disability and deny entry to many newcomers on health and disability-related grounds. In the United States, quarantine and other such policies began in the nineteenth century, and were long influenced by both racism and eugenics; more recently, many nations around the globe have imposed travel bans, barring entry by people who are HIV positive. Nations also perpetuate disability discrimination, excluding immigrants with a range of disabilities on the theory that they will be unproductive and costly to taxpayers. These health- and disability-related immigration exclusions fail to protect public health and reinforce stigma and discrimination against immigrants and natives with disabilities.