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Genome maintenance

Jan Vijg

in Aging of the Genome: The dual role of DNA in life and death

Published in print:
2007
Published Online:
April 2010
ISBN:
9780198569237
eISBN:
9780191728242
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569237.003.0004
Subject:
Biology, Evolutionary Biology / Genetics

This chapter reviews the various genome-maintenance pathways that satisfy the specific need of DNA for stability, with a focus on eukaryotes and mammalian cells. Topics discussed include genome ... More


The Origin of Cancer

Jeffrey Ecsedy and David Hunter

in Textbook of Cancer Epidemiology

Published in print:
2008
Published Online:
September 2009
ISBN:
9780195311174
eISBN:
9780199865093
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195311174.003.0003
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

One of the major goals in cancer research is to elucidate the molecular and cellular events driving the progression of cells from a normal to a cancerous state. This transformation relies on the ... More


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