K. T. Ng and M. E. Gibbs
- Published in print:
- 1991
- Published Online:
- March 2012
- ISBN:
- 9780198521846
- eISBN:
- 9780191724640
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198521846.003.0014
- Subject:
- Neuroscience, Behavioral Neuroscience
This chapter summarizes the findings from a range of pharmacological-behavioural studies carried out in laboratories using a modified version of Cherkin's paradigm. Pharmacological evidence for ...
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This chapter summarizes the findings from a range of pharmacological-behavioural studies carried out in laboratories using a modified version of Cherkin's paradigm. Pharmacological evidence for various stages in memory formation arises from the use of drugs that inhibit, interfere with, or attenuate neuronal processes which are suspected to be involved in memory formation, and observing the consequent effects on behavioural evidence of memory. The time of administration function of an amnestic agent and the consequent retention function together provide the temporal boundaries of a stage of memory. Results of experiments suggest that there is a stage of memory processing preceding the long-term memory stage which is susceptible to blockade by sodium pump inhibitors, which is formed some time between learning and 10 minutes post-learning and which is available for recall after 10 minutes post-learning, and lasts up to 60 minutes post-learning.Less
This chapter summarizes the findings from a range of pharmacological-behavioural studies carried out in laboratories using a modified version of Cherkin's paradigm. Pharmacological evidence for various stages in memory formation arises from the use of drugs that inhibit, interfere with, or attenuate neuronal processes which are suspected to be involved in memory formation, and observing the consequent effects on behavioural evidence of memory. The time of administration function of an amnestic agent and the consequent retention function together provide the temporal boundaries of a stage of memory. Results of experiments suggest that there is a stage of memory processing preceding the long-term memory stage which is susceptible to blockade by sodium pump inhibitors, which is formed some time between learning and 10 minutes post-learning and which is available for recall after 10 minutes post-learning, and lasts up to 60 minutes post-learning.
