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Muscle: The New Physiology

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0017
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Hodgkin and Huxley turn their attention to muscle. Hodgkin measures the membrane and action potentials of the fibres with glass microelectrodes, while Huxley is interested in the nature of the ... More


The Giant Axon Impaled

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0012
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Influenced partly by William Rushton, Alan Hodgkin, a young Trinity College Fellow, has already demonstrated that there are excitability changes in the nerve membrane even when the impulse is ... More


The Voltage Clamp

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0015
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Now in Chicago, Kenneth Cole employs a negative feedback circuit, devised by a colleague, to clamp the voltage across the membrane of the squid giant axon. He shows that during the action potential ... More


Introduction

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0001
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Nerve impulses traversing the brain were likened by Sherrington to points of light in an enchanted loom. The electrochemical nature of the nerve impulse was largely elucidated by Hodgkin and Huxley ... More


Aftermath

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0016
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Lorente de Nó is unable to accept the giant axon work. Hodgkin, however, presses on and shows that it is possible to replace the interior of a giant axon with a potassium solution; the resting ... More


The War Years

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0013
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Plymouth is bombed and the Marine Biological Laboratory damaged. Huxley joins the Navy and Hodgkin helps to develop radar for fighter aircraft. In the depleted physiology department in Cambridge, ... More


Departures

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0022
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

The later lives of the main neurophysiologists in the latter part of the impulse story are described. Edgar Adrian, awarded a baronetcy, abandons research after his laboratory is accidentally ... More


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