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The orbitofrontal cortex in drug addiction

Rita Z. Goldstein, Nelly Alia-Klein, Lisa A. Cottone, and Nora D. Volkow

in The Orbitofrontal Cortex

Published in print:
2006
Published Online:
February 2010
ISBN:
9780198565741
eISBN:
9780191723971
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198565741.003.0019
Subject:
Neuroscience, Behavioral Neuroscience

This chapter reviews the role of the orbitofrontal cortex (OFC) in the clinical characteristics of drug addiction and their putative neuropsychological mechanisms. The OFC's role in reward ... More


Learning Mechanisms in Addictive Disorders

Andreas Heinz

in A New Understanding of Mental Disorders: Computational Models for Dimensional Psychiatry

Published in print:
2017
Published Online:
May 2018
ISBN:
9780262036894
eISBN:
9780262342841
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262036894.003.0008
Subject:
Neuroscience, Behavioral Neuroscience

Addictive disorders may best be described as attribution of salience to drug-associated cues and drug consumption at the expense of other reinforcers. Dopamine and serotonin dysfunction can ... More


Cravings and Addictions: The Contributions of CRF to Approach, Ingestion, and Withdrawal

Jay Schulkin

in The CRF Signal: Uncovering an Information Molecule

Published in print:
2017
Published Online:
June 2017
ISBN:
9780198793694
eISBN:
9780191835506
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198793694.003.0008
Subject:
Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience

The allure of afflictions and appetites gone awry are endless in the modern era. They range from the endless junk food we eat, to the computer games that lock our children to distraction, compulsion, ... More


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