Cattaneo Antonino
- Published in print:
- 2011
- Published Online:
- August 2013
- ISBN:
- 9780262015233
- eISBN:
- 9780262295444
- Item type:
- chapter
- Publisher:
- The MIT Press
- DOI:
- 10.7551/mitpress/9780262015233.003.0026
- Subject:
- Neuroscience, Research and Theory
This chapter describes the connection between the nerve growth factor (NGF) and Alzheimer’s disease (AD). It reveals that NGF can be considered as an anti-amyloidogenic factor that normally keeps the ...
More
This chapter describes the connection between the nerve growth factor (NGF) and Alzheimer’s disease (AD). It reveals that NGF can be considered as an anti-amyloidogenic factor that normally keeps the amyloidogenic pathway under control. It states that the experimental study of AD11 neurodegeneration exhibited a novel causal connection between neurotrophic signaling deficits and Alzheimer’s neurodegeneration. This chapter shows the therapeutic potential of the painless NGF molecules, displaying full neurotrophic activity and reduced pain-related signaling capability.Less
This chapter describes the connection between the nerve growth factor (NGF) and Alzheimer’s disease (AD). It reveals that NGF can be considered as an anti-amyloidogenic factor that normally keeps the amyloidogenic pathway under control. It states that the experimental study of AD11 neurodegeneration exhibited a novel causal connection between neurotrophic signaling deficits and Alzheimer’s neurodegeneration. This chapter shows the therapeutic potential of the painless NGF molecules, displaying full neurotrophic activity and reduced pain-related signaling capability.
Castrén Eero and Fernando Maya Vetencourt José
- Published in print:
- 2011
- Published Online:
- August 2013
- ISBN:
- 9780262015233
- eISBN:
- 9780262295444
- Item type:
- chapter
- Publisher:
- The MIT Press
- DOI:
- 10.7551/mitpress/9780262015233.003.0027
- Subject:
- Neuroscience, Research and Theory
This chapter describes neurotrophins as regulators of visual cortical plasticity. It illustrates that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are popular candidate ...
More
This chapter describes neurotrophins as regulators of visual cortical plasticity. It illustrates that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are popular candidate molecules for synaptic plasticity. It supports the hypothesis that antidepressant drugs might increase neuronal plasticity in the cortex at least partially by activating BDNF signaling in brain. This chapter also shows the role of antidepressants as enhancers of plasticity, which is consistent with the fact that these drugs are successfully employed for the treatment of many neuropsychiatric disorders in addition to depression, including anxiety, obsessive-compulsive disorder, chronic pain, and eating disorders.Less
This chapter describes neurotrophins as regulators of visual cortical plasticity. It illustrates that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are popular candidate molecules for synaptic plasticity. It supports the hypothesis that antidepressant drugs might increase neuronal plasticity in the cortex at least partially by activating BDNF signaling in brain. This chapter also shows the role of antidepressants as enhancers of plasticity, which is consistent with the fact that these drugs are successfully employed for the treatment of many neuropsychiatric disorders in addition to depression, including anxiety, obsessive-compulsive disorder, chronic pain, and eating disorders.
