Andersen Per, Morris Richard, Amaral David, Bliss Tim, and O’Keefe John
- Published in print:
- 2006
- Published Online:
- May 2009
- ISBN:
- 9780195100273
- eISBN:
- 9780199864133
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195100273.003.0002
- Subject:
- Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience
This chapter presents a historical discussion of the key discoveries and concepts of hippocampal neurobiology of the modern era up to about the 1970s. It is divided into two main sections. The first ...
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This chapter presents a historical discussion of the key discoveries and concepts of hippocampal neurobiology of the modern era up to about the 1970s. It is divided into two main sections. The first provides a selective overview of some of the historically important proposals concerning the function of the hippocampus. The second highlights the historically significant advances in neurobiology that have been made by using the unique structure of the hippocampus for studies ranging from defining the morphology of excitatory and inhibitory synapses to developing computational models of memory. This second section is itself divided into subsections that emphasize first the biological characteristics of the hippocampus and then the advantages of the hippocampus as a model system for neurobiological research.Less
This chapter presents a historical discussion of the key discoveries and concepts of hippocampal neurobiology of the modern era up to about the 1970s. It is divided into two main sections. The first provides a selective overview of some of the historically important proposals concerning the function of the hippocampus. The second highlights the historically significant advances in neurobiology that have been made by using the unique structure of the hippocampus for studies ranging from defining the morphology of excitatory and inhibitory synapses to developing computational models of memory. This second section is itself divided into subsections that emphasize first the biological characteristics of the hippocampus and then the advantages of the hippocampus as a model system for neurobiological research.
Andersen Per, Morris Richard, Amaral David, Bliss Tim, and O’Keefe John
- Published in print:
- 2006
- Published Online:
- May 2009
- ISBN:
- 9780195100273
- eISBN:
- 9780199864133
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195100273.003.0001
- Subject:
- Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience
This chapter begins with a brief discussion of the reasons behind the interest of scientists in the hippocampus. It then considers the importance of studying the hippocampus on its own, followed by ...
More
This chapter begins with a brief discussion of the reasons behind the interest of scientists in the hippocampus. It then considers the importance of studying the hippocampus on its own, followed by discussion of the contemporary era of hippocampal research that started in the 1960s. An overview of the subsequent chapters is presented.Less
This chapter begins with a brief discussion of the reasons behind the interest of scientists in the hippocampus. It then considers the importance of studying the hippocampus on its own, followed by discussion of the contemporary era of hippocampal research that started in the 1960s. An overview of the subsequent chapters is presented.
Thorsten Bartsch (ed.)
- Published in print:
- 2012
- Published Online:
- September 2012
- ISBN:
- 9780199592388
- eISBN:
- 9780199949922
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199592388.001.0001
- Subject:
- Neuroscience, Disorders of the Nervous System, Behavioral Neuroscience
The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body ...
More
The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical, and neurocomputational literature that presents basic mechanisms, theoretical models, and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. This book explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural, and psychiatric symptoms and surpasses the ability to encode, store, and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia.Less
The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical, and neurocomputational literature that presents basic mechanisms, theoretical models, and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. This book explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural, and psychiatric symptoms and surpasses the ability to encode, store, and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia.
