Partridge John G. and Vicini Stefano
- Published in print:
- 2011
- Published Online:
- August 2013
- ISBN:
- 9780262015233
- eISBN:
- 9780262295444
- Item type:
- chapter
- Publisher:
- The MIT Press
- DOI:
- 10.7551/mitpress/9780262015233.003.0018
- Subject:
- Neuroscience, Research and Theory
This chapter investigates the modulation of synaptic N-methyl D-aspartate (NMDA) receptors in striatal medium spiny neurons by the presence of endogenous dopamine. It demonstrates that an interaction ...
More
This chapter investigates the modulation of synaptic N-methyl D-aspartate (NMDA) receptors in striatal medium spiny neurons by the presence of endogenous dopamine. It demonstrates that an interaction is occurring between ascorbate and dopamine. It also illustrates that ascorbate could facilitate the lifetime of dopamine acting synaptically by altering the oxidation state of dopamine (DA). This chapter then shows a novel regulation of NMDA receptor-mediated synaptic responses that may have relevance for neurological diseases of the basal ganglia.Less
This chapter investigates the modulation of synaptic N-methyl D-aspartate (NMDA) receptors in striatal medium spiny neurons by the presence of endogenous dopamine. It demonstrates that an interaction is occurring between ascorbate and dopamine. It also illustrates that ascorbate could facilitate the lifetime of dopamine acting synaptically by altering the oxidation state of dopamine (DA). This chapter then shows a novel regulation of NMDA receptor-mediated synaptic responses that may have relevance for neurological diseases of the basal ganglia.
