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Analysis of DNA methylation in cancer

Fabian Model, Jörn Lewin, Catherine Lofton-Day, and Gunter Weiss

in Statistics and Informatics in Molecular Cancer Research

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199532872
eISBN:
9780191714467
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199532872.003.0005
Subject:
Mathematics, Probability / Statistics, Biostatistics

This chapter gives an overview of algorithms and statistical methods used for measuring and analyzing DNA methylation in cancer research. It starts with a short introduction into the biology of DNA ... More


Latent Variable Models for Analyzing DNA Methylation

E. Andrés Houseman

in Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Published in print:
2014
Published Online:
December 2014
ISBN:
9780198709022
eISBN:
9780191779619
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198709022.003.0015
Subject:
Mathematics, Probability / Statistics, Biostatistics

Deoxyribonucleic acid (DNA) methylation is tightly linked with cellular differentiation. For instance, it has been observed that DNA methylation in tumor cells encodes phenotypic information about ... More


Bayesian Networks in the Study of Genome-wide DNA Methylation

Meromit Singer and Lior Pachter

in Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Published in print:
2014
Published Online:
December 2014
ISBN:
9780198709022
eISBN:
9780191779619
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198709022.003.0014
Subject:
Mathematics, Probability / Statistics, Biostatistics

This chapter explores the use of Bayesian networks in the study of genome-scale deoxyribonucleic acid (DNA) methylation. It begins by describing different experimental methods for the genome-scale ... More


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