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Balancing Selection and Disease

Norman A. Johnson

in Darwinian Detectives: Revealing the Natural History of Genes and Genomes

Published in print:
2007
Published Online:
September 2007
ISBN:
9780195306750
eISBN:
9780199790203
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195306750.003.0005
Subject:
Biology, Evolutionary Biology / Genetics

Some forms of selection, called “balancing selection” can maintain variation. Human beta-hemoglobin is an example of a gene under balancing selection. Individuals having two copies of the sickle ... More


Human genetic diversity and HIV

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0014
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

Human genetic variation modulates susceptibility to infection with the human immunodeficiency virus (HIV) and progression to acquired immunodeficiency syndrome (AIDS) through diverse mechanisms ... More


Virus Dynamics and Arms Races

Ricard Solé and Santiago F. Elena

in Viruses as Complex Adaptive Systems

Published in print:
2018
Published Online:
May 2019
ISBN:
9780691158846
eISBN:
9780691185118
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691158846.003.0004
Subject:
Biology, Evolutionary Biology / Genetics

The life histories of viruses cannot be understood outside the context of their host partners. Because they cannot exist without the environment defined by their target organisms, understanding the ... More


Sexually transmitted diseases

Robert L. Perlman

in Evolution and Medicine

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199661718
eISBN:
9780191774720
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199661718.003.0008
Subject:
Biology, Evolutionary Biology / Genetics

Sexually transmitted pathogens and sexually transmitted diseases (STDs) are widespread in nature. Humans can be infected by over a dozen sexually transmitted pathogens. Sexually transmitted ... More


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