Oliver Quarrell
- Published in print:
- 2020
- Published Online:
- February 2021
- ISBN:
- 9780198844389
- eISBN:
- 9780191926815
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/oso/9780198844389.001.0001
- Subject:
- Clinical Medicine and Allied Health, Clinical Medicine
Huntington’s disease (HD)―the facts provides an overview of the condition aimed at families and carers understanding the condition. It describes the key features of: a movement disorder, disturbance ...
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Huntington’s disease (HD)―the facts provides an overview of the condition aimed at families and carers understanding the condition. It describes the key features of: a movement disorder, disturbance of mood (affect), and problems with thinking (cognition) and behaviour. The movement problems of chorea, dystonia, and bradykinesia are explained but there is equal emphasis on depression impulsive behaviour and temper outbursts. Understanding the cause of these may help families cope better when they arise. The genetic change is discussed as is its effect on the protein huntingtin. Options for genetic testing of those at risk (predictive testing) as well as options for tests in pregnancy (prenatal diagnosis) and preimplantation genetic diagnosis (PGD) are described. Currently treatment is symptomatic and supportive. There is a discussion of clinical trials in general and the current huntingtin lowering studies using anti-sense oligonucleotides (ASOs) in particular. The book also includes vignettes written by family members.Less
Huntington’s disease (HD)―the facts provides an overview of the condition aimed at families and carers understanding the condition. It describes the key features of: a movement disorder, disturbance of mood (affect), and problems with thinking (cognition) and behaviour. The movement problems of chorea, dystonia, and bradykinesia are explained but there is equal emphasis on depression impulsive behaviour and temper outbursts. Understanding the cause of these may help families cope better when they arise. The genetic change is discussed as is its effect on the protein huntingtin. Options for genetic testing of those at risk (predictive testing) as well as options for tests in pregnancy (prenatal diagnosis) and preimplantation genetic diagnosis (PGD) are described. Currently treatment is symptomatic and supportive. There is a discussion of clinical trials in general and the current huntingtin lowering studies using anti-sense oligonucleotides (ASOs) in particular. The book also includes vignettes written by family members.
Piers Page, James Carr, William Eardley, David Chadwick, and Keith Porter
- Published in print:
- 2011
- Published Online:
- November 2020
- ISBN:
- 9780199570072
- eISBN:
- 9780191917868
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/oso/9780199570072.001.0001
- Subject:
- Clinical Medicine and Allied Health, Clinical Medicine
This practical book is written specifically for junior doctors by a team of highly experienced authors, as an introductory guide to clinical research. It covers all areas that a ...
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This practical book is written specifically for junior doctors by a team of highly experienced authors, as an introductory guide to clinical research. It covers all areas that a junior doctor needs to consider, including funding, study design, ethics, data analysis, disseminating findings, and furthering one's research career. It presents a balance view of clinical research and is written by authors actively involved in clinical research both at the 'coal-face' and at a more supervisory level. Research can be a difficult process and it is essential to make sure that the project is set up in the correct way in order to get verifiable results. This easy-to-read guide is available to help junior doctors develop a good study design and present evidence of a sound academic practice, which will make obtaining funding more likely and be time-efficient. Getting started early in research and developing a solid, gradual understanding of clinical research through using this approachable book will be of huge benefit to junior doctors and their discipline.
Less
This practical book is written specifically for junior doctors by a team of highly experienced authors, as an introductory guide to clinical research. It covers all areas that a junior doctor needs to consider, including funding, study design, ethics, data analysis, disseminating findings, and furthering one's research career. It presents a balance view of clinical research and is written by authors actively involved in clinical research both at the 'coal-face' and at a more supervisory level. Research can be a difficult process and it is essential to make sure that the project is set up in the correct way in order to get verifiable results. This easy-to-read guide is available to help junior doctors develop a good study design and present evidence of a sound academic practice, which will make obtaining funding more likely and be time-efficient. Getting started early in research and developing a solid, gradual understanding of clinical research through using this approachable book will be of huge benefit to junior doctors and their discipline.
Melania the Younger
Aeschylus: Suppliant Women
Appian: Wars of the Romans in Iberia
Aristophanes: Ecclesiazusae
Aristophanes: Knights
Aristophanes: Wasps
Aristotle: On Sleep and Dreams
Arthur Szyk
Athens in Jerusalem
