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The Constituents of Life 2: Organisms and Systems

John Dupré

in Processes of Life: Essays in the Philosophy of Biology

Published in print:
2012
Published Online:
May 2012
ISBN:
9780199691982
eISBN:
9780191738111
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199691982.003.0006
Subject:
Philosophy, Philosophy of Science

This chapter develops the argument of Chapter 4. Further discussion of the importance of microbes leads to a stress on the importance and ubiquity of symbiosis. This, in turn, motivates the ... More


Aging of the Genome: The dual role of DNA in life and death

Jan Vijg

Published in print:
2007
Published Online:
April 2010
ISBN:
9780198569237
eISBN:
9780191728242
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569237.001.0001
Subject:
Biology, Evolutionary Biology / Genetics

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been ... More


Nonparametric Bayesian Networks *

Katja Ickstadt, Bjöorn Bornkamp, Marco Grzegorczyk, Jakob Wieczorek, Malik R. Sheriff, Hernáan E. Grecco, and Eli Zamir

in Bayesian Statistics 9

Published in print:
2011
Published Online:
January 2012
ISBN:
9780199694587
eISBN:
9780191731921
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199694587.003.0010
Subject:
Mathematics, Probability / Statistics

A convenient way of modelling complex interactions is by employing graphs or networks which correspond to conditional independence structures in an underlying statistical model. One main class of ... More


Threats to the CBW Prohibition Regimes: The Revolution in the Life Sciences

in Preventing a Biochemical Arms Race

Published in print:
2012
Published Online:
June 2013
ISBN:
9780804782753
eISBN:
9780804786157
Item type:
chapter
Publisher:
Stanford University Press
DOI:
10.11126/stanford/9780804782753.003.0003
Subject:
Political Science, Conflict Politics and Policy

This chapter addresses developments in science and technology that have particular implications for biosecurity. It concentrates on functional genomics, synthetic biology, systems biology, ... More


System Modeling in Cellular Biology: From Concepts to Nuts and Bolts

Zoltan Szallasi, Jorg Stelling, and Vipul Periwal (eds)

Published in print:
2006
Published Online:
August 2013
ISBN:
9780262195485
eISBN:
9780262257060
Item type:
book
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262195485.001.0001
Subject:
Mathematics, Mathematical Biology

Research in systems biology requires the collaboration of researchers from diverse backgrounds, including biology, computer science, mathematics, statistics, physics, and biochemistry. These ... More


A New Biology?

Alfred I. Tauber

in Immunity: The Evolution of an Idea

Published in print:
2017
Published Online:
February 2017
ISBN:
9780190651244
eISBN:
9780190651275
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780190651244.003.0006
Subject:
Philosophy, Philosophy of Science

To describe the immune system’s organization and regulation, immunologists are following ecologists, molecular biologists, physiologists, and neuroscientists in their attempts to establish ... More


The Role of Modeling in Systems Biology

Douglas B. Kell and Joshua D. Knowles

in System Modeling in Cellular Biology: From Concepts to Nuts and Bolts

Published in print:
2006
Published Online:
August 2013
ISBN:
9780262195485
eISBN:
9780262257060
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262195485.003.0001
Subject:
Mathematics, Mathematical Biology

This chapter discusses some of the reasons for seeking to model complex cellular biological systems. It begins by presenting a philosophical overview and historical context. It then considers the ... More


Integrative ecological genomics

Nico M. van Straalen and Dick Roelofs

in An Introduction to Ecological Genomics

Published in print:
2011
Published Online:
December 2013
ISBN:
9780199594689
eISBN:
9780191774812
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199594689.003.0304
Subject:
Biology, Ecology

Systems biology is a new discipline of the life sciences that aims to integrate the knowledge generated by genomics, transcriptomics, proteomics, and metabolomics to obtain a picture of the ... More


Computational Constraints on Modeling in Systems Biology

Vipul Periwal

in System Modeling in Cellular Biology: From Concepts to Nuts and Bolts

Published in print:
2006
Published Online:
August 2013
ISBN:
9780262195485
eISBN:
9780262257060
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262195485.003.0015
Subject:
Mathematics, Mathematical Biology

This chapter reviews various computational algorithms and data structures that are relevant for systems biology. It also provides a summary of the computational aspects of sorting, searching, dynamic ... More


On Modules and Modularity

Zoltan Szallasi, Vipul Periwal, and Jörg Stelling

in System Modeling in Cellular Biology: From Concepts to Nuts and Bolts

Published in print:
2006
Published Online:
August 2013
ISBN:
9780262195485
eISBN:
9780262257060
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262195485.003.0003
Subject:
Mathematics, Mathematical Biology

The complexity of biological systems requires unifying, simplifying concepts that might allow a predictive understanding of their functioning. Suggestions for such concepts include “modularity” along ... More


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