Jump to ContentJump to Main Navigation

You are looking at 1-20 of 24 items

  • Keywords: senescence x
Clear All Modify Search

View:

Models of Cellular Regulation

Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Published in print:
2008
Published Online:
September 2008
ISBN:
9780198570912
eISBN:
9780191718717
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198570912.001.0001
Subject:
Physics, Soft Matter / Biological Physics

The human genome of three billion letters has been sequenced. So have the genomes of thousands of other organisms. With unprecedented resolution, modern technologies are allowing us to peek into the ... More


Selection in multicellular organisms

Graham Bell

in Selection: The Mechanism of Evolution

Published in print:
2007
Published Online:
May 2008
ISBN:
9780198569725
eISBN:
9780191717741
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569725.003.0005
Subject:
Biology, Evolutionary Biology / Genetics

The development of multicellular organisms involves a balance between somatic and reproductive tissues. This chapter outlines how the action of selection is influenced by the age at which structures ... More


 A Journey through the Interdisciplinary Landscape of Biodemography

S. Jay Olshansky and Bruce A. Carnes

in Interdisciplinary Research: Case Studies from Health and Social Science

Published in print:
2008
Published Online:
September 2008
ISBN:
9780195324273
eISBN:
9780199893966
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195324273.003.0020
Subject:
Psychology, Cognitive Neuroscience, Cognitive Psychology

This chapter presents an interdisciplinary collaboration that has made scientific contributions to the emerging field of biodemography. It identities personal and professional challenges that emerge ... More


Less Food, Less Sex, Live Longer?

Stephen J. Simpson and David Raubenheimer

in The Nature of Nutrition: A Unifying Framework from Animal Adaptation to Human Obesity

Published in print:
2012
Published Online:
October 2017
ISBN:
9780691145655
eISBN:
9781400842803
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691145655.003.0004
Subject:
Biology, Animal Biology

This chapter examines the relationships between nutrition, life span, and sex. It considers the view that dietary restriction without severe malnutrition prolongs life. It is generally believed that ... More


Life-history patterns

Anne E. Magurran

in Evolutionary Ecology: The Trinidadian Guppy

Published in print:
2005
Published Online:
September 2007
ISBN:
9780198527855
eISBN:
9780191713576
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198527855.003.0005
Subject:
Biology, Evolutionary Biology / Genetics

Guppy populations differ not only in their mating tactics but also in how they make their investment in reproduction. Life history traits such as age and size at maturity, number and size of ... More


Cell aging and renewal

Baltazar D. Aguda and Avner Friedman

in Models of Cellular Regulation

Published in print:
2008
Published Online:
September 2008
ISBN:
9780198570912
eISBN:
9780191718717
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198570912.003.0010
Subject:
Physics, Soft Matter / Biological Physics

Cellular aging, commonly referred to as cellular senescence, is thought to be a ‘programmed’ cell fate in a similar sense that apoptosis is somehow programmed to happen to certain cells during ... More


Introduction

Karen Chase

in The Victorians and Old Age

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199564361
eISBN:
9780191722592
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199564361.003.0001
Subject:
Literature, 19th-century and Victorian Literature, 20th-century Literature and Modernism

The book illuminates the cluster of signs upon which the Victorians drew in order to derive meaning from the experience of growing old within a culture just beginning to take age into full account. ... More


Mechanisms of aging in human populations

Maris Kuningas and Rudi G.J. Westendorp

in Mechanisms of Life History Evolution: The Genetics and Physiology of Life History Traits and Trade-Offs

Published in print:
2011
Published Online:
December 2013
ISBN:
9780199568765
eISBN:
9780191774591
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199568765.003.0016
Subject:
Biology, Evolutionary Biology / Genetics

Ample evidence from model organisms has indicated that subtle variation in genes can dramatically influence lifespan. The key genes and molecular mechanisms that have been identified so far encode ... More


Modeling of the Craniofacial Architecture during Ontogenesis and Phylogenesis

Anne Dambricourt-Malassé and Marie-Josèphe Deshayes

in The Head-Neck Sensory Motor System

Published in print:
1992
Published Online:
March 2012
ISBN:
9780195068207
eISBN:
9780199847198
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195068207.003.0004
Subject:
Neuroscience, Sensory and Motor Systems

Clinical, paleontologic, and ontogenetic data manifest that throughout the development of primates, morphogenesis is at all times closely related to the neurocranium and the face. Now, only in man ... More


Brain Changes in Aging: A Lifespan Perspective

Randy L. Buckner Denise and Head Cindy Lustig

in Lifespan Cognition: Mechanisms of Change

Published in print:
2006
Published Online:
March 2012
ISBN:
9780195169539
eISBN:
9780199847204
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195169539.003.0003
Subject:
Psychology, Cognitive Psychology

While the constellation of observed cognitive changes in advanced aging eludes a simple, parsimonious explanation, there is a recurring distinction between cognitive decline associated with executive ... More


Engineering substantially prolonged human lifespans: biotechnological enhancement and ethics

Peter Derkx

in Valuing older people: A humanist approach to ageing

Published in print:
2009
Published Online:
March 2012
ISBN:
9781847422927
eISBN:
9781447304173
Item type:
chapter
Publisher:
Policy Press
DOI:
10.1332/policypress/9781847422927.003.0011
Subject:
Sociology, Gerontology and Ageing

Before embarking on an ethical discussion, this chapter begins by distinguishing four possible outcomes of a biotechnological enhancement of the human lifespan – extended morbidity, compressed ... More


Introduction

Lawrence R. Walker

in The Biology of Disturbed Habitats

Published in print:
2011
Published Online:
December 2013
ISBN:
9780199575299
eISBN:
9780191774836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199575299.003.0001
Subject:
Biology, Ecology

This introductory chapter discusses the types of disturbance (natural, anthropogenic, allogenic, autogenic) caused by loss (or sometimes addition) of biomass or ecosystem function. Causes and ... More


The Moral Case against Radical Life Extension

Nicholas Agar

in Truly Human Enhancement: A Philosophical Defense of Limits

Published in print:
2014
Published Online:
May 2014
ISBN:
9780262026635
eISBN:
9780262318976
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262026635.003.0006
Subject:
Biology, Bioethics

This chapter uses Aubrey de Grey’s plan to end aging as an example of the radical enhancement of human life spans. I present the enterprise of radically extending human life spans as requiring an ... More


Equivocal Life: Goethe’s Journals on Morphology

Amanda Jo Goldstein

in Sweet Science: Romantic Materialism and the New Logics of Life

Published in print:
2017
Published Online:
January 2018
ISBN:
9780226458441
eISBN:
9780226458588
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226458588.003.0003
Subject:
Literature, 18th-century Literature

This chapter and the next focus on Goethe’s periodicals On Morphology for their paradigmatically neo-Lucretian treatment of biological life and its poetic documentation. In the morphology project, ... More


Time-Neutral Reproduction, Time-Neutral Aging

in Contingent Lives: Fertility, Time, and Aging in West Africa

Published in print:
2002
Published Online:
March 2013
ISBN:
9780226058511
eISBN:
9780226058504
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226058504.003.0007
Subject:
Anthropology, African Cultural Anthropology

This chapter concerns the critical relation of strength, blood, and muscles to reproduction, noting that chronological age is seen as related only tangentially. It describes the character and pace of ... More


Understanding ageing: biological and social perspectives

Lynne S. Cox, Penelope A. Mason, Mark C. Bagley, David Steinsaltz, Aneta Stefanovska, Alan Bernjak, Peter V.E. McClintock, Anna C. Phillips, Jane Upton, Joanna E. Latimer, and Terence Davis

in The new science of ageing

Published in print:
2014
Published Online:
May 2015
ISBN:
9781447314660
eISBN:
9781447314691
Item type:
chapter
Publisher:
Policy Press
DOI:
10.1332/policypress/9781447314660.003.0002
Subject:
Sociology, Gerontology and Ageing

This chapter discusses the basic biology of ageing. First, it examines the social construction of age which emphasises that what biologists or biogerontologists understand as ageing, cell senescence, ... More


Maternal Effects in Mammals: Conclusions and Future Directions

Jill M. Mateo and Dario Maestripieri

in Maternal Effects in Mammals

Published in print:
2009
Published Online:
February 2013
ISBN:
9780226501192
eISBN:
9780226501222
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226501222.003.0014
Subject:
Biology, Animal Behavior / Behavioral Ecology

This chapter sums up the key findings of this study of maternal effects in mammals. It suggests that maternal effects occur when a mother's phenotype influences her offspring's phenotype independent ... More


The Therapist—Aubrey de Grey’s Strategies for Engineered Negligible Senescence

Nicholas Agar

in Humanity's End: Why We Should Reject Radical Enhancement

Published in print:
2010
Published Online:
August 2013
ISBN:
9780262014625
eISBN:
9780262289122
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262014625.003.0005
Subject:
Philosophy, Philosophy of Science

This chapter describes some of the science behind the strategies for engineered negligible senescence (SENS). It argues that Aubrey de Grey has presented substantial arguments about how we might put ... More


Who Wants to Live Forever?

Nicholas Agar

in Humanity's End: Why We Should Reject Radical Enhancement

Published in print:
2010
Published Online:
August 2013
ISBN:
9780262014625
eISBN:
9780262289122
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262014625.003.0006
Subject:
Philosophy, Philosophy of Science

This chapter argues that the experience of negligible senescence is generally stranger than de Grey would have us believe. It is not simply more of the same, where “the same” picks out the best parts ... More


Towards understanding the biological drivers of cell ageing

Lynne S. Cox and Penelope A. Mason

in The New Dynamics of Ageing Volume 2

Published in print:
2018
Published Online:
January 2019
ISBN:
9781447314783
eISBN:
9781447314806
Item type:
chapter
Publisher:
Policy Press
DOI:
10.1332/policypress/9781447314783.003.0008
Subject:
Sociology, Gerontology and Ageing

This chapter discusses approaches to understanding cellular ageing (senescence) through molecular biology approaches. Current scientific ideas surrounding the biological and evolutionary basis of ... More


View: