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The X‐ray laser and the single molecule — no crystal needed?

Naomi E. Chayen, John R. Helliwell, and Edward H. Snell

in Macromolecular Crystallization and Crystal Perfection

Published in print:
2010
Published Online:
May 2010
ISBN:
9780199213252
eISBN:
9780191707575
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213252.003.0019
Subject:
Physics, Crystallography

Major increases in brightness are anticipated with the upcoming coherent X‐ray lasers. Extrapolation suggests that a single macromolecule ‘sample’ may be sufficient to generate a measurable X‐ray ... More


Crystals, X-rays and Proteins: Comprehensive Protein Crystallography

Dennis Sherwood and Jon Cooper

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199559046
eISBN:
9780191595028
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199559046.001.0001
Subject:
Physics, Crystallography

This book presents a complete account of the theory of the diffraction of X-rays by crystals with particular reference to the processes of determining the structures of protein molecules. The book ... More


The Weak Hydrogen Bond: In Structural Chemistry and Biology

Gautam Desiraju and Thomas Steiner

Published in print:
2001
Published Online:
January 2010
ISBN:
9780198509707
eISBN:
9780191708206
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509707.001.0001
Subject:
Physics, Crystallography

The weak hydrogen bond, also known as non-conventional hydrogen bond, has been the subject of intense scrutiny over recent years in several fields, in particular structural chemistry, structural ... More


Linking sequence to function in drug design with ancestral sequence reconstruction

Janos T. Kodra, Marie Skovgaard, Dennis Madsen, and David A. Liberles

in Ancestral Sequence Reconstruction

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.003.0003
Subject:
Biology, Evolutionary Biology / Genetics

Many bioactive peptides and proteins of pharmaceutical interest are found in animal venoms. Nature often reuses scaffolds within protein frameworks to develop new properties. The binding core of the ... More


Classical cloning, expression, and purification

Jane Skelly, Maninder K. Sohi, and Thil Batuwangala

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0001
Subject:
Biology, Biochemistry / Molecular Biology

The ideal protein-expression strategy for X-ray structural analysis should provide correctly folded, soluble, and active protein in sufficient quantities for successful crystallization. Subsequent ... More


Crystallography in the study of protein–DNA interaction

Maninder K. Sohi and Ivan Laponogov

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0015
Subject:
Biology, Biochemistry / Molecular Biology

In the living cell, protein-DNA interactions take place during genetic processes such as chromatin organization, recombination, replication, transcription, and DNA repair. In order to fully ... More


Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels

Stephen J. Moss and Jeremy Henley (eds)

Published in print:
2002
Published Online:
March 2012
ISBN:
9780192632241
eISBN:
9780191724763
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192632241.001.0001
Subject:
Neuroscience, Molecular and Cellular Systems

This book reviews the recent advances in understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting, and anchoring of the protein complexes making up the ... More


What Developmental Biology Can Tell Us about Innateness *

Gary F. Marcus

in The Innate Mind: Structure and Contents

Published in print:
2005
Published Online:
January 2007
ISBN:
9780195179675
eISBN:
9780199869794
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195179675.003.0002
Subject:
Philosophy, Metaphysics/Epistemology

This chapter examines an apparent tension created by recent research on neurological development and genetics on the one hand and cognitive development on the other. It considers what it might mean ... More


Gene Pleiotropy and Evolution of Protein Sequence

Xun Gu

in Statistical Theory and Methods for Evolutionary Genomics

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199213269
eISBN:
9780191594762
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213269.003.0008
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

The concept of gene pleiotropy may play a key role in developing an integrated view of protein evolution. Although the capacity of a gene that may affect multiple phenotypic characters has been used ... More


Reticulate evolution and beneficial organisms—part II

Michael L. Arnold

in Reticulate Evolution and Humans: Origins and Ecology

Published in print:
2008
Published Online:
January 2009
ISBN:
9780199539581
eISBN:
9780191716225
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199539581.003.0006
Subject:
Biology, Animal Biology, Evolutionary Biology / Genetics

This chapter argues that many of the human foodstuffs generated from animals have evolved at least in part as a result of reticulation. Specifically, introgressive hybridization and hybrid speciation ... More


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