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The X‐ray laser and the single molecule — no crystal needed?

Naomi E. Chayen, John R. Helliwell, and Edward H. Snell

in Macromolecular Crystallization and Crystal Perfection

Published in print:
2010
Published Online:
May 2010
ISBN:
9780199213252
eISBN:
9780191707575
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213252.003.0019
Subject:
Physics, Crystallography

Major increases in brightness are anticipated with the upcoming coherent X‐ray lasers. Extrapolation suggests that a single macromolecule ‘sample’ may be sufficient to generate a measurable X‐ray ... More


Crystals, X-rays and Proteins: Comprehensive Protein Crystallography

Dennis Sherwood and Jon Cooper

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199559046
eISBN:
9780191595028
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199559046.001.0001
Subject:
Physics, Crystallography

This book presents a complete account of the theory of the diffraction of X-rays by crystals with particular reference to the processes of determining the structures of protein molecules. The book ... More


The Weak Hydrogen Bond: In Structural Chemistry and Biology

Gautam Desiraju and Thomas Steiner

Published in print:
2001
Published Online:
January 2010
ISBN:
9780198509707
eISBN:
9780191708206
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509707.001.0001
Subject:
Physics, Crystallography

The weak hydrogen bond, also known as non-conventional hydrogen bond, has been the subject of intense scrutiny over recent years in several fields, in particular structural chemistry, structural ... More


Spin Glasses and Complexity

Daniel L. Stein and Charles M. Newman

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691147338
eISBN:
9781400845637
Item type:
book
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691147338.001.0001
Subject:
Sociology, Science, Technology and Environment

Spin glasses are disordered magnetic systems that have led to the development of mathematical tools with an array of real-world applications, from airline scheduling to neural networks. This book ... More


Linking sequence to function in drug design with ancestral sequence reconstruction

Janos T. Kodra, Marie Skovgaard, Dennis Madsen, and David A. Liberles

in Ancestral Sequence Reconstruction

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.003.0003
Subject:
Biology, Evolutionary Biology / Genetics

Many bioactive peptides and proteins of pharmaceutical interest are found in animal venoms. Nature often reuses scaffolds within protein frameworks to develop new properties. The binding core of the ... More


Classical cloning, expression, and purification

Jane Skelly, Maninder K. Sohi, and Thil Batuwangala

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0001
Subject:
Biology, Biochemistry / Molecular Biology

The ideal protein-expression strategy for X-ray structural analysis should provide correctly folded, soluble, and active protein in sufficient quantities for successful crystallization. Subsequent ... More


Applications to Other Fields

Daniel L. Stein and Charles M. Newman

in Spin Glasses and Complexity

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691147338
eISBN:
9781400845637
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691147338.003.0007
Subject:
Sociology, Science, Technology and Environment

This chapter explores how spin glass concepts have found use in and, in some cases, further advanced areas such as computational complexity, combinatorial optimization, neural networks, protein ... More


Crystallography in the study of protein–DNA interaction

Maninder K. Sohi and Ivan Laponogov

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0015
Subject:
Biology, Biochemistry / Molecular Biology

In the living cell, protein-DNA interactions take place during genetic processes such as chromatin organization, recombination, replication, transcription, and DNA repair. In order to fully ... More


Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels

Stephen J. Moss and Jeremy Henley (eds)

Published in print:
2002
Published Online:
March 2012
ISBN:
9780192632241
eISBN:
9780191724763
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192632241.001.0001
Subject:
Neuroscience, Molecular and Cellular Systems

This book reviews the recent advances in understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting, and anchoring of the protein complexes making up the ... More


What Developmental Biology Can Tell Us about Innateness *

Gary F. Marcus

in The Innate Mind: Structure and Contents

Published in print:
2005
Published Online:
January 2007
ISBN:
9780195179675
eISBN:
9780199869794
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195179675.003.0002
Subject:
Philosophy, Metaphysics/Epistemology

This chapter examines an apparent tension created by recent research on neurological development and genetics on the one hand and cognitive development on the other. It considers what it might mean ... More


Gene Pleiotropy and Evolution of Protein Sequence

Xun Gu

in Statistical Theory and Methods for Evolutionary Genomics

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199213269
eISBN:
9780191594762
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213269.003.0008
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

The concept of gene pleiotropy may play a key role in developing an integrated view of protein evolution. Although the capacity of a gene that may affect multiple phenotypic characters has been used ... More


Chemical communication in societies of rodents

Jane L. Hurst and Robert J. Beynon

in Sociobiology of Communication: an interdisciplinary perspective

Published in print:
2008
Published Online:
September 2008
ISBN:
9780199216840
eISBN:
9780191712043
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199216840.003.0006
Subject:
Biology, Animal Biology, Evolutionary Biology / Genetics

Scents play a central role in rodent societies, communicating information about identity (species, sex, individual, kinship) and status (social, reproductive, health, age). This requires the ... More


Reticulate evolution and beneficial organisms—part II

Michael L. Arnold

in Reticulate Evolution and Humans: Origins and Ecology

Published in print:
2008
Published Online:
January 2009
ISBN:
9780199539581
eISBN:
9780191716225
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199539581.003.0006
Subject:
Biology, Animal Biology, Evolutionary Biology / Genetics

This chapter argues that many of the human foodstuffs generated from animals have evolved at least in part as a result of reticulation. Specifically, introgressive hybridization and hybrid speciation ... More


Simple non-mammalian systems

David A. Pearce

in Lysosomal Disorders of the Brain: Recent Advances in Molecular and Cellular Pathogenesis and Treatment

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198508786
eISBN:
9780191723803
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198508786.003.0010
Subject:
Neuroscience, Disorders of the Nervous System

This chapter begins with a discussion of proteins associated with lysosomal storage diseases and their orthologues in model organisms. It then discusses studies of orthologous proteins associated ... More


Max Perutz and the SPSL

Georgina Ferry

in In Defence of Learning: The Plight, Persecution, and Placement of Academic Refugees, 1933-1980s

Published in print:
2011
Published Online:
January 2013
ISBN:
9780197264812
eISBN:
9780191754029
Item type:
chapter
Publisher:
British Academy
DOI:
10.5871/bacad/9780197264812.003.0006
Subject:
Sociology, Migration Studies (including Refugee Studies)

This chapter focuses on Austrian-born molecular biologist Max Perutz (1914–2002). Perutz was one of twenty scientific refugees from continental Europe who went on to win Nobel Prizes. A chemist and ... More


Macromolecular Crystallography: conventional and high-throughput methods

Mark R. Sanderson and Jane V. Skelly (eds)

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.001.0001
Subject:
Biology, Biochemistry / Molecular Biology

Macromolecular crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of ... More


Molecular Biology of Myelination

Anthony T. Campagnoni

in Neuroglia

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195152227
eISBN:
9780199865024
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195152227.003.0019
Subject:
Neuroscience, Development, Disorders of the Nervous System

This chapter presents a brief overview of the molecular biology of the myelin protein genes and their expression into mRNA and protein. Topics discussed include classic myelin basic proteins and ... More


The Geometry of Human Nutrition

Stephen J. Simpson and David Raubenheimer

in The Nature of Nutrition: A Unifying Framework from Animal Adaptation to Human Obesity

Published in print:
2012
Published Online:
October 2017
ISBN:
9780691145655
eISBN:
9781400842803
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691145655.003.0010
Subject:
Biology, Animal Biology

This chapter explores the methods of nutritional geometry on the modern human diet, applying the geometric approach to an analysis of a key aspect of human nutrition: the topical subject of human ... More


Perspectives

Stephen J. Simpson and David Raubenheimer

in The Nature of Nutrition: A Unifying Framework from Animal Adaptation to Human Obesity

Published in print:
2012
Published Online:
October 2017
ISBN:
9780691145655
eISBN:
9781400842803
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691145655.003.0011
Subject:
Biology, Animal Biology

This concluding chapter looks at some of the big issues that remain in nutritional biology. Exploding protein into its constituent amino acids means having to deal with 19 extra dimensions, which is ... More


The Genetics of Evolutionary Novelties

Günter P. Wagner

in Homology, Genes, and Evolutionary Innovation

Published in print:
2014
Published Online:
October 2017
ISBN:
9780691156460
eISBN:
9781400851461
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691156460.003.0007
Subject:
Biology, Evolutionary Biology / Genetics

This chapter examines the molecular genetics of evolutionary novelties. In particular, it investigates which molecular mechanisms might be involved in the origination of novel gene regulatory ... More


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