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Using ancestral gene resurrection to unravel the evolution of protein function

Joseph W. Thornton and Jamie T. Bridgham

in Ancestral Sequence Reconstruction

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.003.0016
Subject:
Biology, Evolutionary Biology / Genetics

This chapter reviews the use of ancestral gene resurrection to understand how the members of a biologically crucial gene family, the steroid hormone receptors, evolved their diverse and highly ... More


Statistical Description and Evolution of Reactive Gas Systems

Raymond Brun

in Introduction to Reactive Gas Dynamics

Published in print:
2009
Published Online:
May 2009
ISBN:
9780199552689
eISBN:
9780191720277
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199552689.003.0002
Subject:
Physics, Theoretical, Computational, and Statistical Physics

This chapter begins by presenting a statistical definition of state and transport parameters of non-equilibrium flows, starting from the concept of distribution function. It then describes the ... More


Density of states

Enric Canadell, Marie-Liesse Doublet, and Christophe Iung

in Orbital Approach to the Electronic Structure of Solids

Published in print:
2012
Published Online:
December 2013
ISBN:
9780199534937
eISBN:
9780191774935
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199534937.003.0010
Subject:
Physics, Condensed Matter Physics / Materials

This chapter considers ways to condense the information of the full Brillouin zone in simple chemical terms. The simplest analytical tool devised for this purpose is the density of states (DOS). The ... More


Modeling Molecular Interaction Networks with Nonlinear Ordinary Differential Equations

Emery D. Conrad and John J. Tyson

in System Modeling in Cellular Biology: From Concepts to Nuts and Bolts

Published in print:
2006
Published Online:
August 2013
ISBN:
9780262195485
eISBN:
9780262257060
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262195485.003.0006
Subject:
Mathematics, Mathematical Biology

This chapter explains how cell biologists can make reliable connections between molecular interaction networks and cell behaviors, when intuition fails in all but the simplest cases. It proposes to ... More


Computational Modeling Methods for Neuroscientists

Erik De Schutter (ed.)

Published in print:
2009
Published Online:
August 2013
ISBN:
9780262013277
eISBN:
9780262258722
Item type:
book
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262013277.001.0001
Subject:
Neuroscience, Techniques

This book offers an introduction to current methods in computational modeling in neuroscience, and describes realistic modeling methods at levels of complexity ranging from molecular interactions to ... More


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