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Conceiving a Master Molecule

Jan Sapp

in Genesis: The Evolution of Biology

Published in print:
2003
Published Online:
September 2007
ISBN:
9780195156195
eISBN:
9780199790340
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195156195.003.0016
Subject:
Biology, Evolutionary Biology / Genetics

This chapter focuses on the discovery of DNA. The discovery of DNA as the basis of the gene, how it is reproduced, and how it affects protein synthesis was the pinnacle of life sciences in the 20th ... More


Chance, Nécessité, et Naïveté: Ingredients to Create a New Organizational Form

Walter W. Powell and Kurt Sandholtz

in The Emergence of Organizations and Markets

Published in print:
2012
Published Online:
October 2017
ISBN:
9780691148670
eISBN:
9781400845552
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691148670.003.0013
Subject:
Sociology, Economic Sociology

This chapter analyzes the early years of the first generation of biotechnology companies. The setting is the 1970s, a time when landmark scientific discoveries in molecular biology triggered all ... More


Macromolecular Crystallization and Crystal Perfection

Naomi E. Chayen, John R. Helliwell, and Edward H. Snell

Published in print:
2010
Published Online:
May 2010
ISBN:
9780199213252
eISBN:
9780191707575
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213252.001.0001
Subject:
Physics, Crystallography

Structural crystallography provides key information to understand the mechanism involved for biological processes. The technique requires high‐quality crystals. The book Macromolecular ... More


The Age of Model Organisms

Rowland H. Davis

in The Microbial Models of Molecular Biology: From Genes to Genomes

Published in print:
2003
Published Online:
April 2010
ISBN:
9780195154368
eISBN:
9780199893935
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195154368.003.0019
Subject:
Biology, Biochemistry / Molecular Biology

This chapter begins with a description of the attributes of model organisms. It then reviews some of the choices of model organisms discussed in the preceding chapters. It argues that molecular ... More


The Role of Biochemistry

Rowland H. Davis

in The Microbial Models of Molecular Biology: From Genes to Genomes

Published in print:
2003
Published Online:
April 2010
ISBN:
9780195154368
eISBN:
9780199893935
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195154368.003.0017
Subject:
Biology, Biochemistry / Molecular Biology

This chapter takes up three important areas in which continuing progress in molecular biology relied heavily on frankly biochemical orientation. It argues that the often understated contributions of ... More


Exhuming the Three-Man Paper: Target-Theoretical Research in the 1930s and 1940s

Richard H. Beyler

in Creating a Physical Biology: The Three-Man Paper and Early Molecular Biology

Published in print:
2011
Published Online:
September 2013
ISBN:
9780226767826
eISBN:
9780226762777
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226762777.003.0004
Subject:
History, History of Science, Technology, and Medicine

This chapter shows that, far from having been buried, the Three-Man Paper (3MP) was cited—often with approval, occasionally with disapproval—in the work of biophysicists in at least a dozen or so ... More


Yeast Becomes a Supermodel

Rowland H. Davis

in The Microbial Models of Molecular Biology: From Genes to Genomes

Published in print:
2003
Published Online:
April 2010
ISBN:
9780195154368
eISBN:
9780199893935
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195154368.003.0015
Subject:
Biology, Biochemistry / Molecular Biology

This chapter focuses on how yeast became the prime focus of eukaryotic molecular biology after 1975. It summarizes some of the major studies in yeast biology. It shows how progress in disentangling ... More


“Mass Migration” and Technologies of Gene Manipulation

Doogab Yi

in The Recombinant University: Genetic Engineering and the Emergence of Stanford Biotechnology

Published in print:
2015
Published Online:
September 2015
ISBN:
9780226143835
eISBN:
9780226216119
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226216119.003.0002
Subject:
History, History of Science, Technology, and Medicine

Chapter 2 examines these changing dynamics, and the scientific and political genealogy of recombinant DNA technology. I argue that recombinant DNA technology derived from particular experimental ... More


Max Perutz and the SPSL

Georgina Ferry

in In Defence of Learning: The Plight, Persecution, and Placement of Academic Refugees, 1933-1980s

Published in print:
2011
Published Online:
January 2013
ISBN:
9780197264812
eISBN:
9780191754029
Item type:
chapter
Publisher:
British Academy
DOI:
10.5871/bacad/9780197264812.003.0006
Subject:
Sociology, Migration Studies (including Refugee Studies)

This chapter focuses on Austrian-born molecular biologist Max Perutz (1914–2002). Perutz was one of twenty scientific refugees from continental Europe who went on to win Nobel Prizes. A chemist and ... More


Searching for the Science

Barbara Forrest and Paul R. Gross

in Creationism's Trojan Horse: The Wedge of Intelligent Design

Published in print:
2004
Published Online:
April 2010
ISBN:
9780195157420
eISBN:
9780199894000
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195157420.003.0004
Subject:
Biology, Evolutionary Biology / Genetics

Phase I of the intelligent design movement’s strategy as outlined in the Wedge Document is devoted to “Scientific Research, Writing & Publicity.” The Discovery Institute provides lucrative ... More


Introduction

Phillip R. Sloan and Fogel Brandon

in Creating a Physical Biology: The Three-Man Paper and Early Molecular Biology

Published in print:
2011
Published Online:
September 2013
ISBN:
9780226767826
eISBN:
9780226762777
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226762777.003.0001
Subject:
History, History of Science, Technology, and Medicine

This book is primarily concerned with the “Three-Man Paper” or the 3MP. Though its particular scientific conclusions would not stand the test of time, the 3MP was an important stimulus in the ... More


The NMDA Receptor

G. L. Collingridge and J. C. Watkins (eds)

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.001.0001
Subject:
Neuroscience, Molecular and Cellular Systems

This book comprises coverage of the NMDA receptor. The NMDA receptor is an important protein in the brain, which is involved in physiological processes such as synaptic transmission and synaptic ... More


The Microbial Models of Molecular Biology: From Genes to Genomes

Rowland H. Davis

Published in print:
2003
Published Online:
April 2010
ISBN:
9780195154368
eISBN:
9780199893935
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195154368.001.0001
Subject:
Biology, Biochemistry / Molecular Biology

This book explains the role of simple biological model systems in the growth of molecular biology. Essentially, the whole history of molecular biology is presented here, tracing the work in ... More


DNA

Rowland H. Davis

in The Microbial Models of Molecular Biology: From Genes to Genomes

Published in print:
2003
Published Online:
April 2010
ISBN:
9780195154368
eISBN:
9780199893935
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195154368.003.0010
Subject:
Biology, Biochemistry / Molecular Biology

This chapter considers how DNA changed the agenda and how microbial genetics became a backbone of molecular biology. In particular, it summarizes the main impact of the work on the choice and uses of ... More


Reductionism and Developmental Molecular Biology

in Darwinian Reductionism: Or, How to Stop Worrying and Love Molecular Biology

Published in print:
2006
Published Online:
March 2013
ISBN:
9780226727295
eISBN:
9780226727318
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226727318.003.0003
Subject:
Philosophy, Philosophy of Science

This chapter argues that the sudden success of molecular developmental biology will turn reductionism from an exercise in philosophical handwaving into “normal science.” It shows that before ... More


Introduction Biology's Untenable Dualism

in Darwinian Reductionism: Or, How to Stop Worrying and Love Molecular Biology

Published in print:
2006
Published Online:
March 2013
ISBN:
9780226727295
eISBN:
9780226727318
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226727318.003.0001
Subject:
Philosophy, Philosophy of Science

This introductory chapter discusses how the combination of physicalism and antireductionism is an untenable dualism. This book argues that the physicalist must be a reductionist. But the physicalist ... More


Integrating mechanistic and evolutionary analysis of life history variation

Christian Braendle, Andreas Heyland, and Thomas Flatt

in Mechanisms of Life History Evolution: The Genetics and Physiology of Life History Traits and Trade-Offs

Published in print:
2011
Published Online:
December 2013
ISBN:
9780199568765
eISBN:
9780191774591
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199568765.003.0001
Subject:
Biology, Evolutionary Biology / Genetics

This introductory chapter provides a brief overview of life history theory and outlines empirical approaches towards understanding the evolution of life histories. It argues that in order to arrive ... More


Are There Really Informational Genes and Developmental Programs?

in Darwinian Reductionism: Or, How to Stop Worrying and Love Molecular Biology

Published in print:
2006
Published Online:
March 2013
ISBN:
9780226727295
eISBN:
9780226727318
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226727318.003.0004
Subject:
Philosophy, Philosophy of Science

The motivation for seeking a refutation of the claimed uniqueness of the gene in the causation of development is very strong. The details of attempts to refute genetic determinism by undermining ... More


Strategies to apply when high‐quality crystals cannot be obtained

Naomi E. Chayen, John R. Helliwell, and Edward H. Snell

in Macromolecular Crystallization and Crystal Perfection

Published in print:
2010
Published Online:
May 2010
ISBN:
9780199213252
eISBN:
9780191707575
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213252.003.0006
Subject:
Physics, Crystallography

Once a crystal has been obtained that is suitable for crystallographic data collection using X‐rays or neutrons there are several strategies that may be combined to improve the quality and/or size of ... More


The Synapse: Function, Plasticity, and Neurotrophism

Motoy Kuno

Published in print:
1994
Published Online:
March 2012
ISBN:
9780198546870
eISBN:
9780191724350
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198546870.001.0001
Subject:
Neuroscience, Molecular and Cellular Systems

The synapse not only provides a bridge from one nerve cell to the next; its function can be modified by experience, making it important for learning and memory. This overview of the synapse provides ... More


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