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Lessons from haemoglobin

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0001
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

Study of genetic variation at the globin genes has provided a series of fundamental insights the nature and extent of genetic diversity and its functional consequences. This chapter provides a primer ... More


Respiratory systems

A. Schmidt-Rhaesa

in The Evolution of Organ Systems

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198566687
eISBN:
9780191718007
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198566687.003.0011
Subject:
Biology, Evolutionary Biology / Genetics

Oxygen uptake is essential for animals, and many animals take up oxygen through their external surface. In these cases particular respiratory structures are not formed; in water these are generally ... More


Balancing Selection and Disease

Norman A. Johnson

in Darwinian Detectives: Revealing the Natural History of Genes and Genomes

Published in print:
2007
Published Online:
September 2007
ISBN:
9780195306750
eISBN:
9780199790203
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195306750.003.0005
Subject:
Biology, Evolutionary Biology / Genetics

Some forms of selection, called “balancing selection” can maintain variation. Human beta-hemoglobin is an example of a gene under balancing selection. Individuals having two copies of the sickle ... More


Genetic haematological disorders

Sir David Weatherall and Elizabeth A. Letsky

in Antenatal and Neonatal Screening

Published in print:
2000
Published Online:
September 2009
ISBN:
9780192628268
eISBN:
9780191723605
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192628268.003.0011
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This main focus of this chapter is on genetic disorders of the structure or synthesis of haemoglobin — especially sickle cell disease and the thalassaemias, which are common enough in many ... More


Malaria

Robert L. Perlman

in Evolution and Medicine

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199661718
eISBN:
9780191774720
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199661718.003.0009
Subject:
Biology, Evolutionary Biology / Genetics

Despite recent progress in reducing the prevalence of malaria, it remains a major cause of morbidity and mortality, especially in infants and young children. Malaria is the infectious disease that ... More


Sickle Cell Disease

Omar Niss and Russell E. Ware

in Pediatric and Adult Nutrition in Chronic Diseases, Developmental Disabilities, and Hereditary Metabolic Disorders: Prevention, Assessment, and Treatment

Published in print:
2017
Published Online:
April 2017
ISBN:
9780199398911
eISBN:
9780199398942
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199398911.003.0034
Subject:
Public Health and Epidemiology, Public Health

This chapter discusses sickle cell disease and related conditions, including biochemical, pathological, and clinical abnormalities and factors to be considered in nutritional evaluation (e.g., ... More


The Modern Synthesis: Discussion

Eva Jablonka

in Transformations of Lamarckism: From Subtle Fluids to Molecular Biology

Published in print:
2011
Published Online:
August 2013
ISBN:
9780262015141
eISBN:
9780262295642
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262015141.003.0014
Subject:
Biology, Evolutionary Biology / Genetics

This chapter discusses important issues concerning the Modern Synthesis. First, it describes the neglected ideas and overlooked theories of Cyril Darlington. It then discusses the decline of the ... More


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