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Molecular and Genetic Events in Neoplastic Transformation

AYSE E. ERSON and ELIZABETH M. PETTY

in Cancer Epidemiology and Prevention

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195149616
eISBN:
9780199865062
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195149616.003.0004
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter illustrates some of the basic molecular and genetic mechanisms that underlie the development of cancer. The chapter is organized into four main sections. The first section examines ... More


Aging of the Genome: The dual role of DNA in life and death

Jan Vijg

Published in print:
2007
Published Online:
April 2010
ISBN:
9780198569237
eISBN:
9780191728242
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569237.001.0001
Subject:
Biology, Evolutionary Biology / Genetics

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been ... More


Epilogue

Jan Vijg

in Aging of the Genome: The dual role of DNA in life and death

Published in print:
2007
Published Online:
April 2010
ISBN:
9780198569237
eISBN:
9780191728242
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569237.003.0009
Subject:
Biology, Evolutionary Biology / Genetics

This epilogue presents some concluding thoughts from the author. Increased stochasticity, beginning at the level of the genome, may work its way through the system and eventually translate into aging ... More


A genomic limit to life?

Jan Vijg

in Aging of the Genome: The dual role of DNA in life and death

Published in print:
2007
Published Online:
April 2010
ISBN:
9780198569237
eISBN:
9780191728242
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569237.003.0008
Subject:
Biology, Evolutionary Biology / Genetics

A model, presented in Chapter 7, tentatively explains how random mutations can lead not only to cancer, but also to reduced function of the highly differentiated cells in vertebrates. Aging would ... More


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