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Ancestral Sequence Reconstruction

David A Liberles (ed.)

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.001.0001
Subject:
Biology, Evolutionary Biology / Genetics

Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological ... More


Models of Cellular Regulation

Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Published in print:
2008
Published Online:
September 2008
ISBN:
9780198570912
eISBN:
9780191718717
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198570912.001.0001
Subject:
Physics, Soft Matter / Biological Physics

The human genome of three billion letters has been sequenced. So have the genomes of thousands of other organisms. With unprecedented resolution, modern technologies are allowing us to peek into the ... More


Perspectives

ZIHENG YANG

in Computational Molecular Evolution

Published in print:
2006
Published Online:
April 2010
ISBN:
9780198567028
eISBN:
9780191728280
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198567028.003.0010
Subject:
Biology, Evolutionary Biology / Genetics

This chapter discusses current challenges and future perspectives of the field. Topics covered include theoretical issues in phylogeny reconstruction, computational issues in analysis of large and ... More


Beyond the Genome

Jan Sapp

in Genesis: The Evolution of Biology

Published in print:
2003
Published Online:
September 2007
ISBN:
9780195156195
eISBN:
9780199790340
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195156195.003.0017
Subject:
Biology, Evolutionary Biology / Genetics

This chapter focuses on the outcomes of the human genome project. Topics discussed include the complexity of decoding the human genome, DNA as a genetic plan, old dogmas about DNA, cell architecture ... More


Rose's Strategy of Preventive Medicine

Geoffrey Rose, Kay-Tee Khaw, and Michael Marmot

Published in print:
2008
Published Online:
September 2009
ISBN:
9780192630971
eISBN:
9780191723551
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192630971.001.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The Strategy of Preventive Medicine, by Geoffrey Rose, first published in 1993 remains a key text for anyone involved in preventive medicine. Rose's insights into the inextricable ... More


Fine scale sequence diversity and signatures of selection

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0010
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

Genetic diversity observed in human populations provides unique insights into the selective pressures which have shaped our recent evolutionary past. Evidence to support this view is described in ... More


Beyond linear sequence comparisons: the use of genome-level characters for phylogenetic reconstruction

Jeffrey L. Boore and Susan I. Fuerstenberg

in Animal Evolution: Genomes, Fossils, and Trees

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199549429
eISBN:
9780191721601
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199549429.003.0013
Subject:
Biology, Evolutionary Biology / Genetics, Developmental Biology

The first whole genomes to be compared for phylogenetic inference were those of mitochondria, which provided the first sets of genome-level characters for phylogenetic reconstruction. Most powerful ... More


Clonality within the Individual

John C. Avise

in Clonality: The Genetics, Ecology, and Evolution of Sexual Abstinence in Vertebrate Animals

Published in print:
2008
Published Online:
January 2009
ISBN:
9780195369670
eISBN:
9780199871063
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195369670.003.0001
Subject:
Biology, Evolutionary Biology / Genetics

Although clonality is often discussed in reference to whole organisms, the phenomenon also applies to (and is underlain by) genetic processes operating within each individual. All forms of clonal ... More


Conflicting messages: genomic imprinting and internal communication

David Haig

in Sociobiology of Communication: an interdisciplinary perspective

Published in print:
2008
Published Online:
September 2008
ISBN:
9780199216840
eISBN:
9780191712043
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199216840.003.0012
Subject:
Biology, Animal Biology, Evolutionary Biology / Genetics

Behavioural ecology and cell biology both use the language of communication and signalling. In cell biology, signaller and receiver are cells of a single body or molecules encoded by a single genome ... More


The Synaptic Organization of the Brain

Gordon M. Shepherd (ed.)

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195159561
eISBN:
9780199864447
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195159561.001.1
Subject:
Neuroscience, Molecular and Cellular Systems, Development

Synapses are the contact sites that enable neurons to form connections between each other in order to transmit and process neural information. Synaptic organization is concerned with the principles ... More


Genome-Wide Association Studies: Back to the Future

Margaret Lock

in The Alzheimer Conundrum: Entanglements of Dementia and Aging

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691149783
eISBN:
9781400848461
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691149783.003.0007
Subject:
Anthropology, Social and Cultural Anthropology

This chapter examines findings from the newly developed technology of genome-wide association studies (GWAS) being applied to the investigation of Alzheimer disease (AD), primarily in the United ... More


Darwinian Detectives: Revealing the Natural History of Genes and Genomes

Norman A. Johnson

Published in print:
2007
Published Online:
September 2007
ISBN:
9780195306750
eISBN:
9780199790203
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195306750.001.0001
Subject:
Biology, Evolutionary Biology / Genetics

Some six million years ago, two branches of the evolutionary tree diverged: one that led to chimpanzees and bonobos, and one that led to us. Extraordinary advances in our ability to obtain and ... More


Inside the Human Genome: A Case for Non-Intelligent Design

John C. Avise

Published in print:
2010
Published Online:
May 2010
ISBN:
9780195393439
eISBN:
9780199775415
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393439.001.0001
Subject:
Biology, Evolutionary Biology / Genetics

Humanity's physical design flaws have long been apparent—we get hemorrhoids and impacted wisdom teeth, for instance—but do the imperfections extend down to the molecular level of our genes? Inside ... More


Human genome epidemiology: the road map revisited

Muin J. Khoury, Sara R. Bedrosian, Marta Gwinn, Julian Little, Julian P. T. Higgins, and John P. A. Ioannidis

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter begins with a discussion of the Rationale for a Second Edition of Human Genome Epidemiology. It then discusses public health applications of genome-wide association studies, the ... More


Principles of analysis of germline genetics

Jesus Gonzalez-Bosquet and Stephen J. Chanock

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0002
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter presents an overview of the development and progress in applications of genomic technologies, with a focus on genomic sequence variation. Topics discussed include genetic variation, ... More


Case-control and cohort studies in the age of genome-wide associations

Teri Manolio

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0006
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Environmental modifiers of the effects of genetic variants, or gene-environment interactions, have received increased attention in recent years due to the recognition that genetic variants alone are ... More


The emergence of networks in human genome epidemiology: challenges and opportunities

Daniela Seminara, Muin J. Khoury, Thomas R. O’Brien, Teri Manolio, Marta Gwinn, Julian Little, Julian P. T. Higgins, Jonine L. Bernstein, Paolo Boffetta, Melissa L. Bondy, Molly S. Bray, Paul E. Brenchley, Patricia A. Buffler, Juan Pablo Casas, Anand P. Chokkalingam, John Danesh, George Davey Smith, Siobhan M. Dolan, Ross Duncan, Nelleke A. Gruis, Mia Hashibe, David J. Hunter, Marjo-Riitta Jarvelin, Beatrice Malmer, Demetrius M. Maraganore, Julia A. Newton-Bishop, Elio Riboli, Georgia Salanti, Emanuela Taioli, Nic Timpson, André G. Uitterlinden, Paolo Vineis, Nick Wareham, Deborah M. Winn, Ron Zimmern, and John P. A. Ioannidis

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0007
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The Human Genome Epidemiology Network (HuGENet) recently launched a global network of consortia working on human genome epidemiology. This Network of Investigator Networks aims to create a resource ... More


Design and analysis issues in genome-wide association studies

Duncan C. Thomas

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0008
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The recent availability of commercial high-density genotyping technologies, combined with the identification of subsets of single nucleotide polymorphisms (SNPs) that are capable of “tagging” most of ... More


Superweeds Revisited: Tall Stacks of Transgenes and Waffling Gene Flow

C. Neal Stewart

in Genetically Modified Planet: Environmental Impacts of Genetically Engineered Plants

Published in print:
2004
Published Online:
September 2007
ISBN:
9780195157451
eISBN:
9780199790388
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195157451.003.0010
Subject:
Biology, Biotechnology

The first generation of transgenic plants had only one or two transgenes inserted, but future products will have several transgenes stacked together in single plants. The best way to assess risks ... More


Integration of the evidence on gene–disease associations: methods of HuGE reviews

Julian P. T. Higgins and Julian Little

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0011
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Human Genome Epidemiology (HuGE) reviews have been a cornerstone of the efforts of the Human Genome Epidemiology Network (HuGENet) to develop an online resource to house the cumulative and changing ... More


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