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The challenge of assessing complex gene– environment and gene–gene interactions

Peter Kraft and David J. Hunter

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0009
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses the study of gene-environment and gene-gene interactions in genetic epidemiology. It starts with a review of the definition of statistical gene-environment interaction, which ... More


Genetic Modifiers of Cancer Risk

NEIL E. CAPORASO

in Cancer Epidemiology and Prevention

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195149616
eISBN:
9780199865062
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195149616.003.0029
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses genetic modifiers of cancer risk. Topics covered include rationale for the study of low-penetrance genes, the role of low-penetrance genes in cancer susceptibility, ... More


The Interaction of Nature and Nurture:An Integrated Concept

James Tabery

in Beyond Versus: The Struggle to Understand the Interaction of Nature and Nurture

Published in print:
2014
Published Online:
January 2015
ISBN:
9780262027373
eISBN:
9780262324144
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262027373.003.0006
Subject:
History, History of Science, Technology, and Medicine

Scientists have been debating the interaction of nature and nurture for nearly a century. Over those 100 years, two radically different visions of interaction have emerged—one side understanding it ... More


Introduction

Sara Shostak

in Exposed Science: Genes, the Environment, and the Politics of Population Health

Published in print:
2013
Published Online:
January 2017
ISBN:
9780520275171
eISBN:
9780520955240
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520275171.003.0001
Subject:
Public Health and Epidemiology, Public Health

Defining Vulnerabilities opens with a description of the history of childhood lead poisoning in the United States, which frames the puzzle at the center of this book: why and how did environmental ... More


Its Rise, Its Fall, Its Rise? Interaction in the Twenty-First Century

James Tabery

in Beyond Versus: The Struggle to Understand the Interaction of Nature and Nurture

Published in print:
2014
Published Online:
January 2015
ISBN:
9780262027373
eISBN:
9780262324144
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262027373.003.0004
Subject:
History, History of Science, Technology, and Medicine

In 2003, Terrie Moffitt and Avshalom Caspi published a groundbreaking study examining how the serotonin transporter gene and stressful life events interact to contribute to the risk of developing ... More


Gene-Environment Interplay For The Study Of Political Behaviors

Jason D. Boardman

in Man Is by Nature a Political Animal: Evolution, Biology, and Politics

Published in print:
2011
Published Online:
September 2013
ISBN:
9780226319094
eISBN:
9780226319117
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226319117.003.0006
Subject:
Political Science, Political Theory

The gene-environment interplay perspective is a relatively new and exciting area in the social sciences. It has garnered a great deal of attention in the study of physical and mental health and it ... More


Of Dogs, Daycare, and Discipline: A “Genetic Guide to Parenting”?

James Tabery

in Beyond Versus: The Struggle to Understand the Interaction of Nature and Nurture

Published in print:
2014
Published Online:
January 2015
ISBN:
9780262027373
eISBN:
9780262324144
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262027373.003.0008
Subject:
History, History of Science, Technology, and Medicine

Depending on which gene a child has, being sent to daycare can either increase or decrease a child’s chances of developing allergies. Likewise, children with one form of a gene respond better to an ... More


Novel Study Designs and Their Application in Reproductive and Perinatal Epidemiology

Enrique F. Schisterman

in Reproductive and Perinatal Epidemiology

Published in print:
2011
Published Online:
May 2011
ISBN:
9780195387902
eISBN:
9780199895328
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195387902.003.0102
Subject:
Public Health and Epidemiology, Epidemiology

The ultimate goal of epidemiology is to uncover the determinants of health and disease. In the absence of experimental designs, we must rely upon observational designs, which necessitate caution in ... More


Genes, environment, and psychological well-being

Michael Pluess and Michael J. Meaney

in Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686674
eISBN:
9780191766787
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686674.003.0015
Subject:
Psychology, Cognitive Psychology, Evolutionary Psychology

The field of psychology has a long history of debating to what degree psychological traits are determined by genetic predispositions versus environmental factors. According to quantitative behavioral ... More


Contemporary Mainstream Epidemiologic Theory: Biomedical and Lifestyle

Nancy Krieger

in Epidemiology and the People’s Health: Theory and Context

Published in print:
2011
Published Online:
May 2011
ISBN:
9780195383874
eISBN:
9780199893607
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195383874.003.0005
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Chapter 5 critically analyzes the biomedical and lifestyle approaches dominating epidemiologic theorizing and research since the mid-20th century. Tracing the origins of the term “biomedicine,” it ... More


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