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The challenge of assessing complex gene– environment and gene–gene interactions

Peter Kraft and David J. Hunter

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0009
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses the study of gene-environment and gene-gene interactions in genetic epidemiology. It starts with a review of the definition of statistical gene-environment interaction, which ... More


Genetic Modifiers of Cancer Risk

NEIL E. CAPORASO

in Cancer Epidemiology and Prevention

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195149616
eISBN:
9780199865062
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195149616.003.0029
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses genetic modifiers of cancer risk. Topics covered include rationale for the study of low-penetrance genes, the role of low-penetrance genes in cancer susceptibility, ... More


Introduction

Sara Shostak

in Exposed Science: Genes, the Environment, and the Politics of Population Health

Published in print:
2013
Published Online:
January 2017
ISBN:
9780520275171
eISBN:
9780520955240
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520275171.003.0001
Subject:
Public Health and Epidemiology, Public Health

Defining Vulnerabilities opens with a description of the history of childhood lead poisoning in the United States, which frames the puzzle at the center of this book: why and how did environmental ... More


The Interaction of Nature and Nurture:An Integrated Concept

James Tabery

in Beyond Versus: The Struggle to Understand the Interaction of Nature and Nurture

Published in print:
2014
Published Online:
January 2015
ISBN:
9780262027373
eISBN:
9780262324144
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262027373.003.0006
Subject:
History, History of Science, Technology, and Medicine

Scientists have been debating the interaction of nature and nurture for nearly a century. Over those 100 years, two radically different visions of interaction have emerged—one side understanding it ... More


Its Rise, Its Fall, Its Rise? Interaction in the Twenty-First Century

James Tabery

in Beyond Versus: The Struggle to Understand the Interaction of Nature and Nurture

Published in print:
2014
Published Online:
January 2015
ISBN:
9780262027373
eISBN:
9780262324144
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262027373.003.0004
Subject:
History, History of Science, Technology, and Medicine

In 2003, Terrie Moffitt and Avshalom Caspi published a groundbreaking study examining how the serotonin transporter gene and stressful life events interact to contribute to the risk of developing ... More


Gene-Environment Interplay For The Study Of Political Behaviors

Jason D. Boardman

in Man Is by Nature a Political Animal: Evolution, Biology, and Politics

Published in print:
2011
Published Online:
September 2013
ISBN:
9780226319094
eISBN:
9780226319117
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226319117.003.0006
Subject:
Political Science, Political Theory

The gene-environment interplay perspective is a relatively new and exciting area in the social sciences. It has garnered a great deal of attention in the study of physical and mental health and it ... More


Novel Study Designs and Their Application in Reproductive and Perinatal Epidemiology

Enrique F. Schisterman

in Reproductive and Perinatal Epidemiology

Published in print:
2011
Published Online:
May 2011
ISBN:
9780195387902
eISBN:
9780199895328
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195387902.003.0102
Subject:
Public Health and Epidemiology, Epidemiology

The ultimate goal of epidemiology is to uncover the determinants of health and disease. In the absence of experimental designs, we must rely upon observational designs, which necessitate caution in ... More


Of Dogs, Daycare, and Discipline: A “Genetic Guide to Parenting”?

James Tabery

in Beyond Versus: The Struggle to Understand the Interaction of Nature and Nurture

Published in print:
2014
Published Online:
January 2015
ISBN:
9780262027373
eISBN:
9780262324144
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262027373.003.0008
Subject:
History, History of Science, Technology, and Medicine

Depending on which gene a child has, being sent to daycare can either increase or decrease a child’s chances of developing allergies. Likewise, children with one form of a gene respond better to an ... More


Contemporary Mainstream Epidemiologic Theory: Biomedical and Lifestyle

Nancy Krieger

in Epidemiology and the People’s Health: Theory and Context

Published in print:
2011
Published Online:
May 2011
ISBN:
9780195383874
eISBN:
9780199893607
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195383874.003.0005
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Chapter 5 critically analyzes the biomedical and lifestyle approaches dominating epidemiologic theorizing and research since the mid-20th century. Tracing the origins of the term “biomedicine,” it ... More


Genes, environment, and psychological well-being

Michael Pluess and Michael J. Meaney

in Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686674
eISBN:
9780191766787
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686674.003.0015
Subject:
Psychology, Cognitive Psychology, Evolutionary Psychology

The field of psychology has a long history of debating to what degree psychological traits are determined by genetic predispositions versus environmental factors. According to quantitative behavioral ... More


Genes and Atypical Attention

Kim Cornish and John Wilding

in Attention, Genes, and Developmental Disorders

Published in print:
2010
Published Online:
September 2010
ISBN:
9780195179941
eISBN:
9780199864652
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195179941.003.0003
Subject:
Neuroscience, Behavioral Neuroscience, Development

Chapter 3 introduces the six core neurodevelopmental disorders and their genetic origins. The genetics of four disorders (Fragile X syndrome, Down syndrome, Williams syndrome and 22q11 deletion ... More


Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Michael Pluess (ed.)

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686674
eISBN:
9780191766787
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686674.001.0001
Subject:
Psychology, Cognitive Psychology, Evolutionary Psychology

The science of psychological well-being has gained a lot of interest in the last decade. While it has been shown that psychological well-being is partly heritable, research focused on the ... More


Set-Based Gene × Environment Interaction Tests for Complex Diseases with Application to Genome-Wide Association and Sequencing Studies

Shuo Jiao

in Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262034685
eISBN:
9780262335522
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262034685.003.0004
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

This chapter presents set-based approaches that focus on identifying G X E interactions rather than set-based approaches that are based primarily on detecting G main effects (e.g., via marginal ... More


Modern Family History Studies

Ezra Susser, Sharon Schwartz, Alfredo Morabia, and Evelyn J. Bromet

in Psychiatric Epidemiology: Searching for the Causes of Mental Disorders

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195101812
eISBN:
9780199864096
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195101812.003.30
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Family history studies are now used for a much wider range of purposes than in the past. This chapter discusses their usefulness for refining phenotype definitions, targeting preventive ... More


A Systematic Approach to Understanding Human Variability in Serious, Persistent Offending

John Paul Wright and Kevin M. Beaver

in The Development of Persistent Criminality

Published in print:
2009
Published Online:
May 2009
ISBN:
9780195310313
eISBN:
9780199871384
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195310313.003.0008
Subject:
Psychology, Social Psychology

This chapter presents a detailed discussion of the dynamics between genetic and environmental influences on behavior. It discusses how serious, persistent offenders (SPOs) differ from the general ... More


Empirical: The Biological Sciences

Peter V. Rabins

in The Why of Things: Causality in Science, Medicine, and Life

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231164726
eISBN:
9780231535458
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231164726.003.0007
Subject:
Philosophy, Philosophy of Science

This chapter examines the application of the empirical method to the study of causality by focusing on the biological sciences. In particular, it considers the nature-nurture debate and ... More


An Overview of the RELIEF Algorithm and Advancements

Alexandre Todorov

in Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262034685
eISBN:
9780262335522
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262034685.003.0006
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

The aim of the RELIEF algorithm is to filter out features (e.g., genes, environmental factors) that are relevant to a trait of interest, starting from a set of that may include thousands of ... More


Introduction

James Tabery

in Beyond Versus: The Struggle to Understand the Interaction of Nature and Nurture

Published in print:
2014
Published Online:
January 2015
ISBN:
9780262027373
eISBN:
9780262324144
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262027373.003.0001
Subject:
History, History of Science, Technology, and Medicine

Francis Galton first envisioned a science of “nature versus nurture”—a science devoted to understanding whether nature or nurture contributes more to human traits and a science devoted to using that ... More


Molecular genetics of resilience

Sierra Clifford and Kathryn Lemery-Chalfant

in Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686674
eISBN:
9780191766787
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686674.003.0011
Subject:
Psychology, Cognitive Psychology, Evolutionary Psychology

Resilience, or the maintenance of positive functioning in the face of stressful conditions, is a process which can be observed across social and biological levels throughout the course of ... More


Epigenetics: Significance of the Gene-Environment Interface for Brain Development

Eric B. Keverne

in Pathways to Peace: The Transformative Power of Children and Families

Published in print:
2014
Published Online:
May 2015
ISBN:
9780262027984
eISBN:
9780262321181
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262027984.003.0005
Subject:
Psychology, Developmental Psychology

Brain development in humans extends over a very lengthy time period, initially in utero and subsequently embracing attachment interactions with the mother, social interactions with peers, and the ... More


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