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Ancestral Sequence Reconstruction

David A Liberles (ed.)

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.001.0001
Subject:
Biology, Evolutionary Biology / Genetics

Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological ... More


Measuring Competence? Exploring Firm Effects in Drug Discovery

Rebecca Henderson and Iain Cockburn

in The Nature and Dynamics of Organizational Capabilities

Published in print:
2001
Published Online:
November 2003
ISBN:
9780199248544
eISBN:
9780191596155
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/0199248540.003.0007
Subject:
Economics and Finance, Microeconomics

The chapter explores the role of ‘competence’ in pharmaceutical research. It provides support for the existence of sources of heterogeneity highlighted by the resource‐based view of the firm by ... More


From Molecules to Medicines: The Use of Genetic Resources in Pharmaceutical Research

Astrid J. Scholz

in Engineering Trouble: Biotechnology and Its Discontents

Published in print:
2003
Published Online:
March 2012
ISBN:
9780520237612
eISBN:
9780520937499
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520237612.003.0009
Subject:
History, History of Science, Technology, and Medicine

This chapter describes the drug discovery process in pharmaceutical research to show how deeply the new biotechnologies constitute the politics and economics of genetic resources. The analysis ... More


Taking Advantage of Emergence

Deborah Dougherty

in The Emergence of Novelty in Organizations

Published in print:
2015
Published Online:
April 2015
ISBN:
9780198728313
eISBN:
9780191795275
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198728313.003.0007
Subject:
Business and Management, Innovation

Innovators in complex innovation systems can more productively generate new products if they deliberately take advantage of emergence. Focusing on drug discovery, the chapter develops three abductive ... More


The Drug Discovery Crisis

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0001
Subject:
Public Health and Epidemiology, Public Health

This chapter examines the current problem associated with creating new drugs—that so few proteins are considered druggable. It first traces the history of how existing drugs were created. It then ... More


A New Science of Molecules

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0002
Subject:
Public Health and Epidemiology, Public Health

This chapter explains how small molecules came to be used as drugs and how they function mechanistically. It begins by focusing on the emergence of organic chemistry and the role played by Justus von ... More


Accelerating the Arrival of Next-Generation Drugs

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0013
Subject:
Public Health and Epidemiology, Public Health

This chapter focuses on the challenge of accelerating the development of next-generation drugs against undruggable proteins. There are more than 20,000 proteins encoded in the human genome, but only ... More


The Birth of the First Cancer Drugs

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0003
Subject:
Public Health and Epidemiology, Public Health

This chapter traces the origins of today’s cancer drugs. It begins with the discovery of sulfur mustard in 1886 by the German chemist Viktor Meyer, who synthesized in pure form ... More


A New Company Creating Drug Combinations

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0004
Subject:
Public Health and Epidemiology, Public Health

This chapter focuses on the birth of a biopharmaceutical company that sought to identify combinations of existing drugs that could be effective in diseases that drugs have never been used for. One ... More


The Undruggable RAS Protein

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0005
Subject:
Public Health and Epidemiology, Public Health

This chapter discusses the challenge of creating effective medicines based on information from disease-causing genes by focusing on the history of the RAS oncoprotein. The RAS oncoprotein is a ... More


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