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Macromolecular crystallography in drug design

Sherin S. Abdel-Meguid

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0017
Subject:
Biology, Biochemistry / Molecular Biology

This chapter discusses macromolecular crystallography in drug discovery. Currently, all large and most small pharmaceutical and biotechnology companies have invested in macromolecular ... More


Macromolecular Crystallography: conventional and high-throughput methods

Mark R. Sanderson and Jane V. Skelly (eds)

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.001.0001
Subject:
Biology, Biochemistry / Molecular Biology

Macromolecular crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of ... More


The weak hydrogen bond in supramolecular chemistry

GAUTAM R. DESIRAJU and THOMAS STEINER

in The Weak Hydrogen Bond: In Structural Chemistry and Biology

Published in print:
2001
Published Online:
January 2010
ISBN:
9780198509707
eISBN:
9780191708206
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509707.003.0004
Subject:
Physics, Crystallography

This chapter reviews the weak hydrogen bond in supramolecular chemistry by focusing on the relevance of these interactions in the analysis, design, and synthesis of the structures of molecular ... More


A New Science of Molecules

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0002
Subject:
Public Health and Epidemiology, Public Health

This chapter explains how small molecules came to be used as drugs and how they function mechanistically. It begins by focusing on the emergence of organic chemistry and the role played by Justus von ... More


The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Brent Stockwell

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
book
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.001.0001
Subject:
Public Health and Epidemiology, Public Health

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. This book describes this dilemma and ... More


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