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Parkinson’s Disease

Roger D. Roger and Miles A. Whittington

in Cortical Oscillations in Health and Disease

Published in print:
2010
Published Online:
May 2010
ISBN:
9780195342796
eISBN:
9780199776276
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195342796.003.0005
Subject:
Neuroscience, Molecular and Cellular Systems, Development

Parkinson's Disease is associated with loss of brainstem dopaminergic neurons, and loss of dopaminergic innervation of basal ganglia and cortex. The most disabling clinical symptoms are slowness of ... More


Factors Shaping Later Stages of Dopamine Neuron Development

Robert E. Burke

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0011
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Following their birth in the prenatal period, dopamine neurons of the mesencephalon undergo a complex series of cellular events in response to external cues, which ultimately result in the ... More


From Behavior to Cognition: Functions of Mesostriatal, Mesolimbic, and Mesocortical Dopamine Systems

Trevor W. Robbins

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0014
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter reviews the role of dopamine (DA) in mesostriatal, mesolimbic, and mesocortical systems in experimental animals and humans. It appears that each of these systems is “tuned” according to ... More


Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function

Stan B. Floresco

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0015
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter presents a summary of studies that have investigated the contribution of prefrontal cortex (PFC) dopamine (DA) transmission to higher-order cognition, and compares and contrasts the ... More


Neurocomputational Analysis of Dopamine Function

Daniel Durstewitz

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0018
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Current computational models of dopamine (DA) modulation have worked either from a more abstract neuroalgorithmic level, starting with specific assumptions about DA's computational role and then ... More


The Role of Dopamine in the Motivational Vulnerability to Addiction

George F. Koob and Michel Le Moal

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0026
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter discusses the role of dopamine in addiction. Research over the past 50 years has revealed that the mesocorticolimbic dopamine system has an essential role in the acute reinforcing ... More


Dopamine Dysfunction in Schizophrenia: From Genetic Susceptibility to Cognitive Impairment

Heike Tost, Shabnam Hakimi, and Andreas Meyer-Lindenberg

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0039
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter provides an overview of the causes and effects of dopamine dysfunction in schizophrenia. In doing so, it summarizes historical perspectives and our current scientific knowledge about the ... More


Dopamine Modulation of Forebrain Pathways and the Pathophysiology of Psychiatric Disorders

Anthony A. Grace

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0041
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Dopamine (DA) has received substantial attention due to its involvement in a wide array of neurological and psychiatric disorders, ranging from Parkinson's disease to affective disorders and ... More


Functional Neuroanatomy of Dopamine in the Striatum

Charles R. Gerfen

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0002
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter begins with a discussion of the mesostriatal dopamine system. It then covers striatal patch-matrix compartments, input—output organization of the striatal patch and matrix compartments, ... More


Molecular Pharmacology of the Dopamine Receptors

Michele L. Rankin, Lisa A. Hazelwood, R. Benjamin Free, Yoon Namkung, Elizabeth B. Rex, Rebecca A. Roof, and David R. Sibley

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0006
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Dopamine receptors are rhodopsin-like seven-transmembrane receptors (also called G protein-coupled receptors) that mediate the central and peripheral actions of dopamine. Dopamine receptors are most ... More


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