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Inhibition of substrate synthesis: a pharmacological approach for glycosphingolipid storage disease therapy

Frances M. Platt and Terry D. Butters

in Lysosomal Disorders of the Brain: Recent Advances in Molecular and Cellular Pathogenesis and Treatment

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198508786
eISBN:
9780191723803
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198508786.003.0015
Subject:
Neuroscience, Disorders of the Nervous System

The neuronopathic lysosomal storage diseases are not currently amenable to therapy due to the difficulties of delivering functional enzyme/protein to the brain. Over two decades ago, an alternative ... More


Introduction: Relating Disease to Exposure

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195141566
eISBN:
9780199872145
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141566.003.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The goal of environmental health is the prevention of disease through identification and elimination of environmental hazards or the reduction of exposures. This chapter argues that although exposure ... More


Disease Process Models

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195141566
eISBN:
9780199872145
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141566.003.0006
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter shows how we can use basic descriptive information about the time course of observed biological responses and reasonable estimates of the time profile of tissue concentrations to develop ... More


Where Do We Go From Here?

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195141566
eISBN:
9780199872145
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141566.003.0016
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The previous chapters laid out a systematic approach for constructing disease process models and their related dose metrics, which can advance the integration of exposure assessment and epidemiology. ... More


Legal Considerations in Public Health Surveillance in the United States

Verla S. Neslund, Richard A. Goodman, James G. Hodge, and John P. Middaugh

in Principles & Practice of Public Health Surveillance

Published in print:
2010
Published Online:
September 2010
ISBN:
9780195372922
eISBN:
9780199866090
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195372922.003.0010
Subject:
Public Health and Epidemiology, Public Health

This chapter provides an overview of the legal issues relating to public health surveillance. It discusses the general legal authorities for public health surveillance set forth in constitutional, ... More


Diseases and Populations

Thomas D. Koepsell and Noel S. Weiss

in Epidemiologic Methods: Studying the Occurrence of Illness

Published in print:
2004
Published Online:
September 2009
ISBN:
9780195150780
eISBN:
9780199865161
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150780.003.0002
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter focuses on characteristics of diseases and of populations that are of special importance in epidemiologic research. Topics discussed include case definition, epidemiologic case ... More


Reversible Discrete Disease Processes: Asthma and Indoor Air, Dermatitis and Metalworking Fluids

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195141566
eISBN:
9780199872145
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141566.003.0014
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter illustrates the application of the disease process model approach to discrete reversible disease processes. The process model approach is applied in five steps: (1) identifying and ... More


Dendrites and disease

Christophe Bernard, Mala Shah, and Daniel Johnston

in Dendrites

Published in print:
2007
Published Online:
March 2012
ISBN:
9780198566564
eISBN:
9780191724206
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198566564.003.0020
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter briefly reviews some of the research relating structural changes in dendrites with disease, at least in so far as to provide a beginning reference source for readers interested in ... More


Introduction

Michael W. Dols and Diana E. Immisch

in Majnūn: The Madman in Medieval Islamic Society

Published in print:
1992
Published Online:
October 2011
ISBN:
9780198202219
eISBN:
9780191675218
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198202219.003.0001
Subject:
History, World Medieval History, History of Science, Technology, and Medicine

Whether madness is treatable or transcendental, tragic or trivial, it evokes much interest among scholars because the insane challenge the everyday assumptions about reason and normality and test the ... More


AIDS: The Disease That Fits

Paul U. Unschuld

in What Is Medicine?: Western and Eastern Approaches to Healing

Published in print:
2009
Published Online:
May 2012
ISBN:
9780520257658
eISBN:
9780520944701
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520257658.003.0078
Subject:
Anthropology, Medical Anthropology

AIDS unites the germ theory of disease with systems thinking. AIDS could only arise in the late twentieth century. The encounter with HIV/AIDS has brought tremendous inspiration to virologists' ... More


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