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Inhibition of substrate synthesis: a pharmacological approach for glycosphingolipid storage disease therapy

Frances M. Platt and Terry D. Butters

in Lysosomal Disorders of the Brain: Recent Advances in Molecular and Cellular Pathogenesis and Treatment

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198508786
eISBN:
9780191723803
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198508786.003.0015
Subject:
Neuroscience, Disorders of the Nervous System

The neuronopathic lysosomal storage diseases are not currently amenable to therapy due to the difficulties of delivering functional enzyme/protein to the brain. Over two decades ago, an alternative ... More


Introduction: Relating Disease to Exposure

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195141566
eISBN:
9780199872145
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141566.003.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The goal of environmental health is the prevention of disease through identification and elimination of environmental hazards or the reduction of exposures. This chapter argues that although exposure ... More


Disease Process Models

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195141566
eISBN:
9780199872145
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141566.003.0006
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter shows how we can use basic descriptive information about the time course of observed biological responses and reasonable estimates of the time profile of tissue concentrations to develop ... More


Where Do We Go From Here?

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195141566
eISBN:
9780199872145
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141566.003.0016
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The previous chapters laid out a systematic approach for constructing disease process models and their related dose metrics, which can advance the integration of exposure assessment and epidemiology. ... More


Legal Considerations in Public Health Surveillance in the United States

Verla S. Neslund, Richard A. Goodman, James G. Hodge, and John P. Middaugh

in Principles & Practice of Public Health Surveillance

Published in print:
2010
Published Online:
September 2010
ISBN:
9780195372922
eISBN:
9780199866090
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195372922.003.0010
Subject:
Public Health and Epidemiology, Public Health

This chapter provides an overview of the legal issues relating to public health surveillance. It discusses the general legal authorities for public health surveillance set forth in constitutional, ... More


Diseases and Populations

Thomas D. Koepsell and Noel S. Weiss

in Epidemiologic Methods: Studying the Occurrence of Illness

Published in print:
2004
Published Online:
September 2009
ISBN:
9780195150780
eISBN:
9780199865161
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150780.003.0002
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter focuses on characteristics of diseases and of populations that are of special importance in epidemiologic research. Topics discussed include case definition, epidemiologic case ... More


Reversible Discrete Disease Processes: Asthma and Indoor Air, Dermatitis and Metalworking Fluids

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195141566
eISBN:
9780199872145
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141566.003.0014
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter illustrates the application of the disease process model approach to discrete reversible disease processes. The process model approach is applied in five steps: (1) identifying and ... More


AIDS: The Disease That Fits

Paul U. Unschuld

in What Is Medicine?: Western and Eastern Approaches to Healing

Published in print:
2009
Published Online:
May 2012
ISBN:
9780520257658
eISBN:
9780520944701
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520257658.003.0078
Subject:
Anthropology, Medical Anthropology

AIDS unites the germ theory of disease with systems thinking. AIDS could only arise in the late twentieth century. The encounter with HIV/AIDS has brought tremendous inspiration to virologists' ... More


Dendrites and disease

Christophe Bernard, Mala Shah, and Daniel Johnston

in Dendrites

Published in print:
2007
Published Online:
March 2012
ISBN:
9780198566564
eISBN:
9780191724206
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198566564.003.0020
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter briefly reviews some of the research relating structural changes in dendrites with disease, at least in so far as to provide a beginning reference source for readers interested in ... More


Introduction

Michael W. Dols and Diana E. Immisch

in Majnūn: The Madman in Medieval Islamic Society

Published in print:
1992
Published Online:
October 2011
ISBN:
9780198202219
eISBN:
9780191675218
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198202219.003.0001
Subject:
History, World Medieval History, History of Science, Technology, and Medicine

Whether madness is treatable or transcendental, tragic or trivial, it evokes much interest among scholars because the insane challenge the everyday assumptions about reason and normality and test the ... More


ADHD in Medicine

Susan C. C. Hawthorne

in Accidental Intolerance: How We Stigmatize ADHD and How We Can Stop

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199977383
eISBN:
9780199369928
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199977383.003.0002
Subject:
Philosophy, General

In medicine, the concept of ADHD blends elements from broader disease concepts, ideas about mental illness, social concerns with signs of hyperactivity or inattentiveness, scientific knowledge about ... More


The study of inebriety: medicine and the law

James Nicholls

in The Politics of Alcohol: A History of the Drink Question in England

Published in print:
2009
Published Online:
July 2012
ISBN:
9780719077050
eISBN:
9781781702758
Item type:
chapter
Publisher:
Manchester University Press
DOI:
10.7228/manchester/9780719077050.003.0013
Subject:
Political Science, Political Theory

The period between 1870 and 1918 witnessed intense intellectual and political activity around alcohol addiction. Many writers in the late nineteenth and early twentieth centuries saw the drink ... More


symptom, disease, cause

Jennifer Radden

in Melancholic Habits: Burton's Anatomy & the Mind Sciences

Published in print:
2017
Published Online:
December 2016
ISBN:
9780199348190
eISBN:
9780199348213
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199348190.003.0004
Subject:
Philosophy, Philosophy of Mind, History of Philosophy

Burton’s conceptions of disease and causal explanation have significant implications for his ideas about remedying and averting these aberrant mood states and thought patterns. The symptoms and ... More


Accidental Intolerance: How We Stigmatize ADHD and How We Can Stop

Susan C. C. Hawthorne

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199977383
eISBN:
9780199369928
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199977383.001.0001
Subject:
Philosophy, General

This book examines both standard practice and ongoing controversies in social, medical, scientific, ethical, and philosophical approaches to ADHD. The complex web of concepts, data, needs, and ... More


Medicalisation

Natasha Du Rose

in The governance of female drug users: Women's experiences of drug policy

Published in print:
2015
Published Online:
January 2016
ISBN:
9781847426727
eISBN:
9781447307839
Item type:
chapter
Publisher:
Policy Press
DOI:
10.1332/policypress/9781847426727.003.0004
Subject:
Social Work, Crime and Justice

Chapter 5 is concerned with the public health strand of drug policy discourse and the technology of medicalisation underpinning it. Medicalization operates as a form of control and regulation whereby ... More


The Generation of Evidence in Medicine: Evaluating the Benefits and Harms of Treatment

Carol M. Ashton and Nelda P. Wray

in Comparative Effectiveness Research: Evidence, Medicine, and Policy

Published in print:
2013
Published Online:
September 2013
ISBN:
9780199968565
eISBN:
9780199346080
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199968565.003.0001
Subject:
Public Health and Epidemiology, Public Health

Federal mandates for comparative effectiveness research enacted during the 2000’s are intended to increase the kind of high-quality evidence that doctors and patients need for optimal clinical ... More


“Now That We Know the Medicine Works”: Expanding the Drug Court Model

Rebecca Tiger

in Judging Addicts: Drug Courts and Coercion in the Justice System

Published in print:
2012
Published Online:
March 2016
ISBN:
9780814784068
eISBN:
9780814759417
Item type:
chapter
Publisher:
NYU Press
DOI:
10.18574/nyu/9780814784068.003.0006
Subject:
Sociology, Law, Crime and Deviance

This chapter reflects on the future of drug courts, paying attention to the recent preoccupation of advocates with these courts' institutionalization. It considers how the courts' individualized and ... More


Melancholic Habits: Burton's Anatomy & the Mind Sciences

Jennifer Radden

Published in print:
2017
Published Online:
December 2016
ISBN:
9780199348190
eISBN:
9780199348213
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199348190.001.0001
Subject:
Philosophy, Philosophy of Mind, History of Philosophy

To find a coherent account of normal and abnormal psychology from within Burton’s religious presuppositions and humoral explanations requires selection and interpretation. This reading highlights ... More


Yellow Fever: Stories from Philadelphia and Memphis

Samuel K. Cohn, Jr.

in Epidemics: Hate and Compassion from the Plague of Athens to AIDS

Published in print:
2018
Published Online:
May 2018
ISBN:
9780198819660
eISBN:
9780191859984
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198819660.003.0018
Subject:
History, History of Science, Technology, and Medicine, Social History

As measured by mass evacuation of cities, yellow fever provoked more fear and panic than any other epidemic disease in US history. This chapter concentrates on two of the most devastating epidemics ... More


Introduction

Susan C. C. Hawthorne

in Accidental Intolerance: How We Stigmatize ADHD and How We Can Stop

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199977383
eISBN:
9780199369928
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199977383.003.0001
Subject:
Philosophy, General

The introduction sets the stage by explaining what the common mental disorder ADHD is; establishing the prominence of ADHD in the current U.S. medical, scientific, and cultural landscapes; and ... More


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